2-Hydroxyalkylammonium arylihtoacetates and their effects on the functional activity of thrombocytes

Levkovskaya, G. G.; Guseva, S. A.; Kazimirovskaya, V. B.; Kholdeeva, L. N.; Воронков, М. Г.; Мирскова, А. Н.

doi:10.1007/bf00758565

Cited by 3 publications

(1 citation statement)

References 3 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Tris-(2-hydroxyethyl)ammonium 4-chlorophenylsulfanylacetate ( 1 ) [30] was synthesized in the following manner. To a solution of 4-chlorophenylsulfanylacetic acid 4-Cl-C 6 H 4 SCH 2 COOH (20.25 g, 0.1 mol) in MeOH (100 ml), was added dropwise a methanol (50 ml) solution of tris-(2-hydroxyethyl)amine (14.92 g, 0.1 mol).…”

Section: Resultsmentioning

confidence: 99%

Reaction of pharmacological active tris-(2-hydroxyethyl)ammonium 4-chlorophenylsulfanylacetate with ZnCl2 or NiCl2: first conversion of a protic ionic liquid into metallated ionic liquid

Мирскова

Адамович

Мирсков

et al. 2013

Chemistry Central Journal

View full text Add to dashboard Cite

The reaction of pharmacological active protic ionic liquid tris-(2-hydroxyethyl)ammonium 4-chlorophenylsulfanylacetate H+N(CH2CH2OH)3 ∙ (-OOCCH2SC6H4Cl-4) (1) with zinc or nickel chloride in a ratio of 2:1 affords stable at room temperature powder-like adducts [H+N(CH2CH2OH)3]2 ∙ [M(OOCCH2SC6H4Cl-4)2Cl2]2-, M = Zn (2), Ni (3). By recrystallization from aqueous alcohol compound 2 unexpectedly gives Zn(OOCCH2SC6H4Cl-4)2 ∙ 2H2O (4). Unlike 2, compound 3 gives crystals [N(CH2CH2OH)3]2Ni2+ · [-OOCCH2SC6H4Cl-4]2 (5), which have a structure of metallated ionic liquid. The structure of 5 has been proved by X-ray diffraction analysis. It is the first example of the conversion of a protic ionic liquid into potentially biological active metallated ionic liquid (1 → 3 → 5).

show abstract

Section: Resultsmentioning

confidence: 99%