2-Hydroxyethyl Methacrylate (HEMA): Chemical Properties and Applications in Biomedical Fields

Monthéard, Jean‐Pierre; Chatzopoulos, Michel; Chappard, Daniel

doi:10.1080/15321799208018377

Cited by 371 publications

(240 citation statements)

References 245 publications

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“…11,12 Recently, an alternative approach to modify surface properties of the pHEMA based hydrogel has been proposed. 13 According to this method, PEG coupled monomer could be introduced with a desired density by adjusting the concentration of PEG carrying co-monomer in the polymer structures. Surfaces containing PEG are interesting biomaterials because they exhibit low degrees of protein adsorption and cell adhesion.…”

Section: Introductionmentioning

confidence: 99%

Preparation and characterization of poly(hydroxyethyl methacrylate-co -poly(ethyleneglycol-methacrylate)/hydroxypropyl-chitosan) hydrogel films: Adhesion of rat mesenchymal stem cells

et al. 2011

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This study examined the effects of the surface properties of the materials, such as the hydroxyl, methyl and amino groups, on rat bone marrow derived Mesenchymal Stem Cell (MSC) seeding. A series of hydrogels were prepared in film form using 2-hydroxyethyl methacrylate (pHEMA), poly(ethyleneglycol) methacrylate (PEG-MA), and/or hydroxypropyl-chitosan (HPC). The physicochemical properties of these hydrogel films, such as water content, functional groups, contact angle, surface energy and thermal properties were affected by the composition of the materials. The ability of the MSCs to form colonies, as well as their viability on these materials were also analyzed. The water content of the hydrogel films increased with increasing PEG-MA and HPC ratio in the hydrogel. Contact angle measurements of the surface of the hydrogel films demonstrated that all the materials gave rise to a significantly hydrophilic surface compared to pure pHEMA. The blood protein interactions and platelet adhesion were reduced significantly on the surface of the materials upon the incorporation of PEG-MA compared to the control pure pHEMA and vice versa for HPC. The ability of the MSCs to adhere and form colonies on these materials was also analyzed. The results showed that these materials are suitable candidates to isolate and expand MSCs.

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Section: Introductionmentioning

confidence: 99%

Preparation and characterization of poly(hydroxyethyl methacrylate-co -poly(ethyleneglycol-methacrylate)/hydroxypropyl-chitosan) hydrogel films: Adhesion of rat mesenchymal stem cells

et al. 2011

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“…Comparison between the kinetics of after implantation removal torque increases and physiological fluid uptakes in modified implants undergoing swelling Regenerative medicine has developed a lot and will guarantee many bed-to-bed applications (Montheard et al, 1992;Filmon et al, 2002;Davis et al, 1991;Kabra et al, 1991;Apicella et al, 1993;Peluso et al, 1997;Chow et al, 2010).…”

Section: Fig 12mentioning

confidence: 99%

“…Creating ideal scaffolds for bones is a growing argument for research. Such an ideal framework should provide a rigid and elastic mesh to temporarily replace damaged bone function while creating a bioactive substrate for bone regeneration, integrating it fully (Montheard et al, 1992;Kabra et al, 1991;Schiraldi et al, 2004;Aversa et al, 2017a;2017b).…”

Section: Introductionmentioning

confidence: 99%

Hybrid Ceramo-Polymeric Nano-Diamond Composites

Apicella¹,

Aversa²,

Petrescu³

2018

American Journal of Engineering and Applied Sciences

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This paper discusses a new class of bio-mechanical scaffolds active for tissue engineering based on a nano-diamond-filled hydrophilic polymer matrix. The new biomaterials used have special mechanical and biological properties for which they should be extensively studied for their use for various advanced biomedical applications. The new hybrid material has been prepared using 2 and 5% by volume of detonating nanodiamonds and poly (hydroxy-ethyl-methacrylate) hydrophilic. Both the mechanical and biological properties specific to the nanocomposite are hybrids in nature. The paper presents the analytical procedures of the hybrid material and the preliminary mechanical characterization. This class of hybrid materials has a high potential for biomimetic, osteoconductive and osteoinductive applications as active bio-mechanical bones for increasing osteoblasts and differentiating stem cells. At the same time, these hybrid nano-composites possess a much improved mechanical strength that exceeds the mechanical deficiencies of the hydrogels traditionally used for bone regeneration and can be applied as an osteoinductive coating for metal trabecular scaffolds. Micro-trabecular metal structures coated with active and osteoinductive biomechanical ceramic-polymeric biomechanical scaffolds are proposed to recreate macro and micro-distribution of bone stresses and deformations.

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“…In particular, the HEMA is the subject of numerous original papers and monographs on the synthesis, properties and applications of HEMA-based hydrogels, such as the reviewed article of Montheard et al [40]. The first and the most spectacular application of HEMA-based hydrogels are soft contact lenses developed by Otto Wichterle in 1960 [41][42][43][44].…”

mentioning

confidence: 99%

N-Hydroxyphthalimide Immobilized on Poly(HEA-co-DVB) as Catalyst for Aerobic Oxidation Processes

et al. 2016

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was tested in aerobic oxidation of p-methoxytoluene and α-methylstyrene. The studied reactions were carried out in the presence of AIBN and/or Co(II) salt without solvent or in acetic acid as solvent. It was found that the obtained polymer-supported NHPI catalyst showed the best catalytic performance, which was attributed to a high content of accessible NHPI moieties. The recovery and recycling of the obtained HEA/DVB-NHPI was only possible in reactions proceeded in solvent-free conditions. Abstract In the present study, poly(HEA-co-DVB) was synthesized (loading of OH groups: 8.07 mmol OH/g, crosslinking degree: 6 % DVB) and used for N-hydroxyphthalimide (NHPI) immobilization via ester bond (NHPI loading: 2.06 mmol NHPI/g). The obtained polymeric support and poly(HEA-co-DVB)/NHPI catalyst were characterized by FT-IR and XPS spectroscopy, elemental analysis, thermogravimetry and particle size measurement. The novel polymer-supported NHPI catalyst 1 3

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2-Hydroxyethyl Methacrylate (HEMA): Chemical Properties and Applications in Biomedical Fields

Cited by 371 publications

References 245 publications

Preparation and characterization of poly(hydroxyethyl methacrylate-co -poly(ethyleneglycol-methacrylate)/hydroxypropyl-chitosan) hydrogel films: Adhesion of rat mesenchymal stem cells

Preparation and characterization of poly(hydroxyethyl methacrylate-co -poly(ethyleneglycol-methacrylate)/hydroxypropyl-chitosan) hydrogel films: Adhesion of rat mesenchymal stem cells

Hybrid Ceramo-Polymeric Nano-Diamond Composites

N-Hydroxyphthalimide Immobilized on Poly(HEA-co-DVB) as Catalyst for Aerobic Oxidation Processes

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