2H-Thiazolo[4,5-d][1,2,3]triazole: synthesis, functionalization, and application in scaffold-hopping

Abstract

We have developed 2H-thiazolo[4,5-d][1,2,3]triazole (ThTz), an unprecedented [5-5]-fused heteroaromatic system for medicinal chemistry. C5-sulfonylated ThTz has been commercialized through Tokyo Chemical Industry Ltd (TCI: catalogue number M3881).