2 Iron deficiency in the elderly

Schultz, Barry M.; Freedman, Michael L.

doi:10.1016/s0950-3536(87)80004-5

Cited by 19 publications

(6 citation statements)

References 79 publications

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“…Microcytic hypochromic anaemia among children under-five years has been reported in some other studies [22] [23]. It is commonly caused by iron deficiency, thalassemia syndromes, anaemia of chronic disease and sideroblastic anaemia [24]. In this study, it is likely that the cause of the microcytic anaemia is iron deficiency since children with haemoglobinopathies were excluded from this study.…”

Section: Discussionmentioning

confidence: 71%

Prevalence and Morphological Types of Anaemia among Children Under-Five Years in the Volta Regional Hospital of Ghana

Adu-Amankwaah¹,

Allotey²,

Kwasie³

et al. 2018

OALib

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Background: This study aimed at determining the prevalence and morphological types of anaemia, among children under-five years, who had full blood count (FBC) investigation done at the laboratory of the Volta regional hospital. Methodology: This was a retrospective study of archival FBC test results data for children below 5 years in the laboratory, between1 st July to 31 st December 2015. The FBC results comprised of the hemoglobin (Hb) concentration and the red blood cell indices. Obtained data were analyzed using SPSS version 20.0. Results: A total 451 children were sampled. Anaemia prevalence in this study was 55.0% (248/451) and most of the children suffered from moderate anaemia (42%) (104/248) with mild and severe anaemia being 34% (84/248) and 24% (60/248) respectively. Children with microcytic hypochromic anaemia were 52%, (130/248), while those with normocytic normochromic were 25% (63/248). Conclusion: Anaemia was found in more than half of the children under-five years and microcytic hypochromic anaemia was the commonest morphological type of anaemia. There is need for a multi-disciplinary approach to elucidate the etiology of anaemia in children under-five years.

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Section: Discussionmentioning

confidence: 71%

Prevalence and Morphological Types of Anaemia among Children Under-Five Years in the Volta Regional Hospital of Ghana

Adu-Amankwaah¹,

Allotey²,

Kwasie³

et al. 2018

OALib

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“…In addition, iron deficiency is not infrequent in the general population [28], and also in the elderly [3,29] or patients suffering from heart failure [30]. The frequency of iron deficiency on ICU admission may thus be around 35% [31,32].…”

Section: Implication Of Iron Metabolism In the Anemia Of The Criticalmentioning

confidence: 99%

“…This capacity allows iron to play a major role in oxygen transport (as the central part of hemoglobin) but also in electron transfer, nitrogen fixation or DNA synthesis, all essential reactions for living organisms. Indeed, iron deficiency is the main cause of anemia [1] as well as a cause of fatigue [2,3] and decreased effort capacity [4,5]. However, despite a high frequency of anemia among critically ill patients, with 60 to 66% being anemic at intensive care unit (ICU) admission [6,7], to date little is known about iron deficiency and iron metabolism in critically ill patients [8].…”

Section: Introductionmentioning

confidence: 99%

Iron deficiency in critically ill patients: highlighting the role of hepcidin

2011

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“…It is often impossible to distinguish between these conditions by full blood count appearances alone. Iron deficiency anaemia Thus, to determine iron status, it is usually necessary to as sess iron stores, which arc absent in iron deficiency and normal or increased in chronic disease [5]. Serum or plasma ferritin is the most sensitive and specific indicator of iron deficiency that is available from a standard venous blood sample [6], Ferritin levels are directly related to to tal body iron stores.…”

Section: Introductionmentioning

confidence: 99%

Use of the Erythrogram in the Diagnosis of Iron Deficiency in Elderly Patients

McKay

Stott²,

Holyoake³

et al. 1993

Acta Haematol

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In elderly patients the diagnosis of iron deficiency from full blood count indices is often difficult. We assessed an automated technique (numerical data of the erythrogram; Technicon H*l) by which the proportions of microcytic ( < 60 fl) and/or hypochromic ( < 28 g·dl^-1) red blood cells are determined. Of 472 elderly patients investigated, 100 (21%) were found to have iron deficiency (plasma ferritin ≤45 ng·ml^-1). Less than two-thirds of patients with iron-deficient erythropoiesis (anaemia or microcytosis) had increased proportions of hypochromic and/or microcytic red blood cells. Furthermore, the erythrogram was not sensitive in detecting latent or early iron deficiency. The erythrogram also lacked specificity for iron deficiency anaemia as many patients with mild normocytic anaemia associated with chronic inflammatory disease had increased proportions of hypochromic and/or microcytic red blood cells. Although patients with iron deficiency had increased proportions of hypochromic normocytic (p < 0.01) and normochromic microcytic red blood cells (p < 0.05) compared to those with chronic inflammatory disease and normal or raised iron stores (ferritin ≥100 ng·ml^-1, n = 32). there was a large overlap between these two groups, and the grossly elevated erythrogram results in patients with iron deficiency were almost always associated with a mean cell volume (MCV) < 80 fl, whereas none of the patients with chronic inflammatory disease and normal or raised iron stores had an MCV < 80 fl. Thus the erythrogram does not appear to be of value in the routine assessment of iron status in elderly patients.

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2 Iron deficiency in the elderly

Cited by 19 publications

References 79 publications

Prevalence and Morphological Types of Anaemia among Children Under-Five Years in the Volta Regional Hospital of Ghana

Prevalence and Morphological Types of Anaemia among Children Under-Five Years in the Volta Regional Hospital of Ghana

Iron deficiency in critically ill patients: highlighting the role of hepcidin

Use of the Erythrogram in the Diagnosis of Iron Deficiency in Elderly Patients

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