2-methoxy-4-(((5-nitropyridin-2-yl)imino)methyl)phenol Schiff base ligand and its Cu(II) and Zn(II) complexes: synthesis, characterization and biological investigations

Deepika, P.; Vinusha, H.M.; Begum, M. Yasmin; Ramu, Ramith; Shirahatti, Prithvi S.; Prasad, M. V. N. Ambika

doi:10.1016/j.heliyon.2022.e09648

Cited by 11 publications

(3 citation statements)

References 39 publications

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“…Te loss of remaining C 4 H 4 and C 14 H 7 N 2 O groups takes place within the range 410-870 °C (57.9, calc. 59.2%), and fnally, the stable compound CuO is formed above 870 °C [41,42]. Te TGA of [Co(L)] shows the loss of moisture in the range of 40-150 °C.…”

Section: Termogravimetric Analysismentioning

confidence: 99%

Synthesis, Spectral Characterization, and Biological Activities of Some Metal Complexes Bearing an Unsymmetrical Salen-Type Ligand, (Z)-1-(((2-((E)-(2-Hydroxy-6-methoxybenzylidene)amino)phenyl)amino) methylene) Naphthalen-2(1H)-one

Nguyen

Thi

Bui

et al. 2023

Heteroatom Chemistry

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An unsymmetrical salen-type Schiff base ligand, (Z)-1-(((2-((E)-(2-hydroxy-6-methoxybenzylidene)amino)phenyl)amino)methylene)naphthalen-2(1H)-one, and its Zn(II), Cu(II), Co(II), Mn(II), and Fe(III) complexes were synthesized and characterized by mass (MS), nuclear magnetic resonance (NMR), infrared (IR), ultraviolet-visible (UV-Vis) spectra, and effective magnetic moments. The thermal analyses of the obtained ligand and metal complexes were conducted by thermogravimetric analysis (TGA). Antimicrobial activity of the unsymmetrical Schiff base ligand and its metal complexes were examined for Staphylococcus aureus as Gram-positive bacteria and Escherichia coli as Gram-negative bacteria. In vitro anticancer property of synthetic compounds was estimated against human cancer cell lines, a subline of Hela tumor cell line (KB), and a human liver cancer cell line (HepG-2) as well.

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Section: Termogravimetric Analysismentioning

confidence: 99%

Synthesis, Spectral Characterization, and Biological Activities of Some Metal Complexes Bearing an Unsymmetrical Salen-Type Ligand, (Z)-1-(((2-((E)-(2-Hydroxy-6-methoxybenzylidene)amino)phenyl)amino) methylene) Naphthalen-2(1H)-one

Nguyen

Thi

Bui

et al. 2023

Heteroatom Chemistry

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“…The resultant residue degrades in the range of 500-800 C with a weight loss of 40% due to decomposition of [DEP(Cu)Cl 2 ] and might be in the form of CuO above 700 C. This step was accompanied by exothermic peaks (Figure S15). 62 2-4, and geometric parameters are summarized in Table 1. The geometry around the Cu (II) and Cd (II) centers in [DEP(M) X 2 ] (M = Cu, Cd; X = Cl, Br) is distorted square pyramidal obtained via coordination with nitrogen atoms of tridentate DEP ligand and two halogen atoms.…”

Section: Synthesis and Characterizationmentioning

confidence: 99%

Pyridine‐derived Schiff base copper (II), zinc (II), and cadmium (II) complexes: Synthesis, structural properties, biological evaluation, and docking studies

Nayab

Faisal

Khan

et al. 2023

Applied Organom Chemis

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Herein, Cu (II), Zn (II), and Cd (II) complexes, [DEP(M)X2], encompassing the pyridine‐derived Schiff‐base ligand DEP, where DEP is (E)‐N,N‐diethyl‐2‐([pyridine‐2‐ylmethylene]amino)ethane‐1‐amine, are synthesized. X‐ray diffraction studies reveal distorted square pyramidal geometries for the Cd (II) and Cu (II) complexes, whereas the geometry of [DEP (Zn)Cl2] can best be described as trigonal bipyramidal. The antibacterial potential of DEP and its [DEP(M)X2] complexes were evaluated against four bacterial strains: Salmonella typhi, Escherichia coli, Staphylococcus aureus, and Pseudomonas aeruginosa; five fungal strains: Candida glabrata, Candida albicans, Microsporum canis, Fusarium solani, and Aspergillus flavus; and Leishmania major protozoan. Complexes exhibited superior bactericidal, fungicidal, and leishmanicidal inhibition potential against all tested microbes compared with the free ligand. The preliminary cytotoxic activity of [DEP(M)X2] complexes on breast and colon carcinoma cells, that is, MCF‐7cell line and HCT‐116 cell line, respectively, revealed that studied complexes showed high cytotoxicity compared with ligand (DEP). Among the studied complexes, [DEP (Cd)Br2] exhibited an excellent inhibitory profile, as confirmed by the docking study. The molecular docking studies showed a good correlation between the biological activities of synthesized metal complexes and docking studies. We have confidence in the contribution of these complexes toward the design of new metal‐derived candidates that can treat infectious diseases.

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“…Schiff base are an important class of ligands and played an important role in the development of coordination chemistry as they readily form stable complexes with most transition metal Singh et al, 1998;Yildirm et al, 2022;Pul, 2022;Garnovski et al, 1993). Schiff Base Ligand or [L] and their metal complexes have variety of application, including bactericidal (gram-negative and gram-positive bacteria), anticancerous, flame retardant, clinical, analytical, industrial fields and also in organic synthesis (Ouyang et al, 2022;Raman et al, 2001;Jayabalkrishnan et al, 2002;Sharghi et al, 2003;Gao et al, 2002;Senthamilselvean et al, 2022;Deepika et al, 2022;. Metal complexes of schiff base are studied extensively due to synthetic flexibility of the compounds and their selectivity as well as sensitivity towards the central metal atom.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, spectral characterization and antimicrobial effect of Cu(II) complexes of schiff Base Ligand, N-(3,4- dimethoxybenzylidene)-3-aminopyridine (DMBAP) Derived from 3,4-dimethoxybenzaldehyde and 3-aminopyridine

Kumar

2023

The Scientific Temper

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The present study emphasizes strictly on the synthesis, and characterization of complex 3,4- dimethoxybenzaldehyde and 3-aminopyridine with Cu(II) using several techniques like Elemental Analysis, FTIR spectroscopy, NMR, HRMS, UV-vis spectroscopy, Magnetic Susceptibility and Conductivity Measurements. The Ligand [L] acts as bidentate and co-ordinates through Nitrogen atom of imine group [azomethine group] and Nitrogen atom of pyridine ring. Electronic data of the complexes suggest the probable geometry is octahedral in nature. All the complexes and ligand were screened for their antibacterial activity and behaved non-electrolytic in nature. The metal ligand ratio obeys 1:2 ratio. Antimicrobial studies of gram-positive bacteria (GPB)- (Bacillus subtilis), gram-negative bacteria (GNB)- (E. coli) and some antibiotic reveal the MIC value in the range of (6–20 mm) followed the order [Cu(L)2Cl2]>[Cu(L)2Br2]>Antibiotic>Ligand. Antimicrobial activity has been explained on the basis of Tweedy Chelation Theory (TCT) and Anil’s Conceptual Model of Inhibition (ACMI).

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2-methoxy-4-(((5-nitropyridin-2-yl)imino)methyl)phenol Schiff base ligand and its Cu(II) and Zn(II) complexes: synthesis, characterization and biological investigations

Cited by 11 publications

References 39 publications

Synthesis, Spectral Characterization, and Biological Activities of Some Metal Complexes Bearing an Unsymmetrical Salen-Type Ligand, (Z)-1-(((2-((E)-(2-Hydroxy-6-methoxybenzylidene)amino)phenyl)amino) methylene) Naphthalen-2(1H)-one

Synthesis, Spectral Characterization, and Biological Activities of Some Metal Complexes Bearing an Unsymmetrical Salen-Type Ligand, (Z)-1-(((2-((E)-(2-Hydroxy-6-methoxybenzylidene)amino)phenyl)amino) methylene) Naphthalen-2(1H)-one

Pyridine‐derived Schiff base copper (II), zinc (II), and cadmium (II) complexes: Synthesis, structural properties, biological evaluation, and docking studies

Synthesis, spectral characterization and antimicrobial effect of Cu(II) complexes of schiff Base Ligand, N-(3,4- dimethoxybenzylidene)-3-aminopyridine (DMBAP) Derived from 3,4-dimethoxybenzaldehyde and 3-aminopyridine

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