2'-Methoxy-5'-methoxycarbonylspiro[acridine-9(10H),4'(5'H)-thiazole]

Determination of the binding affinities of plasmid DNA using fluorescent intercalators possessing an acridine skeleton

“…This is in agreement with X-ray studies of acridine [14] and the 9-Aminoacridinium cation [15] affording a planar structure as well as with the dihydroacridine and acridinium derivatives forming shallow and slightly twisted butterfly conformations [16,17]. It was found that the magnitude of the deviation from the planarity can be related to the degree of substitution [18].…”

4-(9,10-Dihydroacridin-9-ylidene)thiosemicarbazide and its five-membered thiazole and six-membered thiazine derivatives

“…The geometric parameters for the acridine moiety in (I), (II) and (III) correspond to aromatic portions (outer rings), whilst the central C9 0 -C9a 0 and C8a 0 -C9 0 bonds pertain very much to typical C-C single bonds and overall the parameters are similar to previous reports (Klika et al, 2001;Imrich et al, 2005;Č erná k et al, 1995). The placement of a labile H atom on N10 0 confirms the NMR assignments (Imrich et al, 2010).…”

“…fivemembered methyl 2-{2-[2-(9,10-dihydroacridin-9-ylidene)-1-methylhydrazinyl]-4-oxo-4,5-dihydro-1,3-thiazol-5-ylidene}acetate, (I), six-membered 2-[2-(9,10-dihydroacridin-9-ylidene)-1-methylhydrazino]-4H-1,3-thiazin-4-one, (II), and unsubstituted 4-(9,10-dihydroacridin-9-ylidene)thiosemicarbazide, (III), were obtained (Imrich et al, 2010) and subjected to X-ray single-crystal analysis. Of more than 70 crystallographic descriptions of structures containing an acridine moiety and several hundred descriptions of structures containing thiazolidine rings (Allen, 2002), only four reports exist which contain both acridine and thiazolidine entities linked in some manner (Klika et al, 2001;Imrich et al, 2005;Č erná k et al, 1995). Furthermore, there are no reports of structures having been examined that contain both acridine and thiazine entities.…”