2-Phenylpyridine Derivatives: Synthesis and Insecticidal Activity against Mythimna separata, Aphis craccivora, and Tetranychus cinnabarinus

Abstract

The increase in the insecticide resistance of pests, such as Mythimna separata, Aphis craccivora Koch, and Tetranychus cinnabarinus, necessitates the development of new heterocyclic compounds with high insecticidal activity. A series of novel 2-phenylpyridine derivatives containing N-phenylbenzamide moieties were designed and synthesised with Suzuki–Miyaura cross-coupling, nucleophilic substitution, and amidation reactions. The reaction conditions in each step are mild, and the product is easy to separate (yield is about 85%). The structures of the compounds were characterised using 1H and 13C NMR spectroscopy and HRMS. Moreover, the insecticidal activity of the compounds was analysed using the leaf dipping method. The compounds 5a, 5d, 5g, 5h, and 5k at 500 mg/L exhibited 100% inhibition against Mythimna separata. Therefore, the 2-phenylpyridine moieties have the potential to lead to the discovery of novel and effective insecticides.

Isolation of anthraquinone derivatives from Rubia cordifolia (Rubiaceae) and their bioactivities against plant pathogenic microorganisms

“…Research on the agricultural activity of R. cordifolia L. mainly focuses on its insecticidal activity, Zhang et al 22,23 first reported the insecticidal activity of R. cordifolia L. ethanol extract against wolfberry aphis (Aphis sp.) and diamondback moth (Plutella xylostella).…”

Synthesis of inventive biphenyl and azabiphenyl derivatives as potential insecticidal agents against the cotton leafworm, Spodoptera littoralis

“…Despite many measures and developments in crop protection, increasing estimates of actual and potential losses according to Food and Agriculture Organization (FAO) are frequently reported [ 4 – 6 ]. One of the major causes is increased pest resistance to insecticides, which has gradually spread and affected crop growth and harvest [ 7 – 10 ]. Over recent decades, the Egyptian cotton leafworm, Spodoptera littoralis , Boisduval (Order; Lepidoptera, Family; Noctuidae) has remained one of the most important and dangerous widespread pests affecting cotton and many important field crops, ornamental plants, vegetables, and weeds in Egypt and many countries over the world [ 10 – 12 ].…”

“…Additionally, compounds containing phenylpyridine derivatives such as halauxifen-methyl, florpyrauxifen-benzyl and boscalid exhibited excellent biological activity against insecticides, fungicides, and herbicides (Fig. 1 ) [ 7 , 26 ]. In the same context, the use of halogenated compounds in the development of agrochemical research has significant expansion in the last decade [ 27 , 28 ].…”