2-Pyridone-functionalized Aza-BODIPY photosensitizer for imaging-guided sustainable phototherapy

Xiao, Wanyue; Wang, Peng; Ou, Changjin; Huang, Xiaoyu; Tang, Yaning; Wu, Meiyan; Si, Weili; Shao, Jinjun; Huang, Wei; Dong, Xiaochen

doi:10.1016/j.biomaterials.2018.08.034

Cited by 106 publications

(69 citation statements)

References 44 publications

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“…Nanotechnology can significantly improve the bioavailability of aza‐BODIPYs by resolving solubility issues in aqueous media, and this has led to the increasing popularity of supramolecular aza‐BODIPY constructs as new biophotonic nanomaterials. Aza‐BODIPY molecules have been encapsulated in polymeric micelles, quantum dots, and inorganic nanoparticles . Nevertheless, the development of new aza‐BODIPY nanoparticles for optical imaging remains of great interest.…”

Section: Figurementioning

confidence: 99%

Stable J‐Aggregation of an aza‐BODIPY‐Lipid in a Liposome for Optical Cancer Imaging

et al. 2019

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Organic building blocks are the centerpieces of “one‐for‐all” nanoparticle development. Herein, we report the synthesis of a novel aza‐BODIPY‐lipid building block and its self‐assembly into a liposomal nanoparticle (BODIPYsome). We observed optically stable NIR J‐aggregation within the BODIPYsome that is likely attributed to J‐dimerization. BODIPYsomes with cholesterol showed enhanced colloidal stability while maintaining a high extinction coefficient (128 mm−1 cm−1) and high fluorescence quenching (99.70±0.09 %), which enables photoacoustic (PA) properties from its intact structure and recovered NIR fluorescence properties when it is disrupted in cancer cells. Finally, its capabilities for optical imaging (PA/fluorescence) were observed in an orthotopic prostate tumor mouse model 24 h after intravenous administration. Overall, the BODIPYsome opens the door for engineering new building blocks in the design of optically stable biophotonic imaging agents.

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Section: Figurementioning

confidence: 99%

Stable J‐Aggregation of an aza‐BODIPY‐Lipid in a Liposome for Optical Cancer Imaging

et al. 2019

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“…In the 81 included studies, 28 types of photosensitive agents were reported for their superior photothermal and photodynamic performances. These agents comprised a series of biocompatible photothermal transduction agents or photosensitizers based on metal, carbon, transition metal dichalcogenides, polymers, and semiconductors, which have significant NIR light-absorption ability and superior light-responsive capabilities 15 , 23 - 26 . They have high photothermal conversion efficiency to generate heat and good photocatalytic characteristics to produce ROS in the NIR region 20 , 27 , 28 .…”

Section: Resultsmentioning

confidence: 99%

NIR light-assisted phototherapies for bone-related diseases and bone tissue regeneration: A systematic review

Wan¹,

Zhang²,

Lv³

et al. 2020

Theranostics

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Recently, the rapid development of biomaterials has induced great interest in the precisely targeted treatment of bone-related diseases, including bone cancers, infections, and inflammation. Realizing noninvasive therapeutic effects, as well as improving bone tissue regeneration, is essential for the success of bone‑related disease therapies. In recent years, researchers have focused on the development of stimuli-responsive strategies to treat bone-related diseases and to realize bone regeneration. Among the various external stimuli for targeted therapy, near infrared (NIR) light has attracted considerable interests due to its high tissue penetration capacity, minimal damage toward normal tissues, and easy remote control properties. The main objective of this systematic review was to reveal the current applications of NIR light-assisted phototherapy for bone-related disease treatment and bone tissue regeneration. Database collection was completed by June 1, 2020, and a total of 81 relevant studies were finally included. We outlined the various therapeutic applications of photothermal, photodynamic and photobiomodulation effects under NIR light irradiation for bone‑related disease treatment and bone regeneration, based on the retrieved literatures. In addition, the advantages and promising applications of NIR light-responsive drug delivery systems for spatiotemporal-controlled therapy were summarized. These findings have revealed that NIR light-assisted phototherapy plays an important role in bone-related disease treatment and bone tissue regeneration, with significant promise for further biomedical and clinical applications.

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“…For biomedical applications, there is a huge restriction that most of BODIPY dyes are hydrophobic, so they are hardly applied in biological environment immediately. The development of novel nanotechnology provides opportunities for hydrophobic molecules, such as BODIPY, to be utilized in the biomedical field (Huang & Han, ; Jiang & Pu, ; J. Li & Pu, ; Q. Miao et al, ; W. Sun, Zhao, Fan, Du, & Peng, ; Q. Tang et al, ; Xiao et al, ). In general, we can construct BODIPY into BODIPY‐containing nanoparticles (BDP NPs) via chemical conjugation and physical encapsulation.…”

Section: Introductionmentioning

confidence: 99%

Tailoring nanoparticles based on boron dipyrromethene for cancer imaging and therapy

Lin

Colombani-Garay

Huang

et al. 2020

WIREs Nanomed Nanobiotechnol

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Boron dipyrromethene (BODIPY), as a traditional fluorescent dye, has drawn increasing attention because of its excellent photophysical properties like adjustable spectra and outstanding photostability. BODIPY dyes could be assembled into nanoparticles for cancer imaging and therapy via rational design. In this review, the bio‐applications of BODIPY‐containing nanoparticles are introduced in detail, such as cellular imaging, near‐infrared fluorescence imaging, computed tomography imaging, photoacoustic imaging, phototherapy, and theranostics. The construction strategies of BODIPY‐containing nanoparticles are emphasized so the review has three sections—self‐assembly of small molecules, chemical conjugation with hydrophilic compounds, and physical encapsulation. This review not only summarizes various and colorific bio‐applications of BODIPY‐containing nanoparticles, but also provides reasonable design methods of BODIPY‐containing nanoparticles for cancer theranostics. This article is categorized under: Diagnostic Tools > in vivo Nanodiagnostics and Imaging

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2-Pyridone-functionalized Aza-BODIPY photosensitizer for imaging-guided sustainable phototherapy

Cited by 106 publications

References 44 publications

Stable J‐Aggregation of an aza‐BODIPY‐Lipid in a Liposome for Optical Cancer Imaging

Stable J‐Aggregation of an aza‐BODIPY‐Lipid in a Liposome for Optical Cancer Imaging

NIR light-assisted phototherapies for bone-related diseases and bone tissue regeneration: A systematic review

Tailoring nanoparticles based on boron dipyrromethene for cancer imaging and therapy

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