2-(<sup>18</sup>F)-Fluoro-2-Deoxy-D-Glucose Positron Emission Tomography Detects Clinical Relevant Adenomas of the Colon: A Prospective Study

Kouwen, M.C.A. van; Nagengast, Fokko M.; Jansen, J. B. M. J.; Oyen, Wim J.G.; Drenth, Joost P.H.

doi:10.1200/jco.2005.02.401

Cited by 83 publications

(49 citation statements)

References 21 publications

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“…Colon adenoma size and dysplasia grade have been reported to correlate with likelihood of detection by PET-CT. 23 However, a correlation between maximum SUV and colon neoplasm histology has not been demonstrated consistently. Although Gutman et al found that mean SUVs increased with higher grades of dysplasia with highest levels in patients with colon cancers, Israel et al did not observe such a progression in SUV values.…”

Section: Discussionmentioning

confidence: 99%

Ability of integrated positron emission and computed tomography to detect significant colonic pathology

Weston

Iyer

Qiao

et al. 2010

Cancer

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BACKGROUND:The ability of integrated positron emission tomography and computed axial tomography (PET‐CT) to detect colonic pathology is not fully defined. The purpose of this study was to assess the ability of PET‐CT to detect colonic pathology and to determine the significance of (18F)2‐fluoro‐2‐deoxyglucose (18F‐FDG) activity noted incidentally in the colon on PET‐CT.METHODS:Records for all patients who underwent PET‐CT and colonoscopy at our institution were reviewed. Patients with history of colonic malignancy or colon surgery were excluded.RESULTS:Fifty‐eight patients had incidental colonic 18F‐FDG activity on PET (Group A) and 272 had none (Group B). In Group A, 65% of patients had pathologic findings detected on colonoscopy that corresponded to the site of PET activity. Standardized uptake value (SUV) readings were not helpful in distinguishing true‐positives from false‐positives. In Group B, 11.8% of patients were found to have significant colonic findings. Lesions not detected by PET‐CT included 4 colon cancers, 7 advanced adenomas, and 10 patients with colonic lymphoma. Overall, the sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and accuracy of PET‐CT for detecting significant pathology were 53%, 93%, 65%, 89%, and 85%, respectively. For detecting colon cancer and adenomas 10 mm or more, the sensitivity, specificity, PPV, NPV, and accuracy of PET‐CT were 72%, 90%, 45%, 96%, and 88%, respectively.CONCLUSIONS:Incidental colonic activity detected by PET‐CT warrants further evaluation with colonoscopy. However, negative PET‐CT does not rule out significant colonic pathology including colon cancer, advanced adenomas, or lymphoma. Cancer 2010. © 2010 American Cancer Society.

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Section: Discussionmentioning

confidence: 99%

Ability of integrated positron emission and computed tomography to detect significant colonic pathology

Weston

Iyer

Qiao

et al. 2010

Cancer

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“…18 F-FDG is actively taken up and accumulates in tumor cells (7). In humans, colorectal adenomas are detected by 18 F-FDG PET to a variable extent depending on adenoma characteristics (8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19). 18 F-FDG PET in a mouse model of intestinal adenomas has not been reported.…”

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confidence: 99%

Total Abdominal ¹⁸F-FDG Uptake Reflects Intestinal Adenoma Burden in Apc Mutant Mice

et al. 2011

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Apc mutant (Apc Min ) mice develop multiple adenomas in their intestines and are widely used to study colorectal carcinogenesis and chemopreventive approaches. Molecular imaging of intestinal adenomas could potentially provide noninvasive longitudinal evaluation of these lesions in living mice. Therefore, the aim of this study was to investigate the role of 18 F-FDG PET in the Apc Min mouse model. Methods: Apc Min mice (n 5 8) fed a purified diet were imaged serially after injection of 18 F-FDG at age 9 and 12 wk using a small-animal PET scanner. Abdominal uptake of the tracer was quantified. After dissection, intestines were imaged separately, and intestinal tracer uptake was quantified. Tracer distribution was compared with results from microscopic examination regarding adenoma number and size. Thereafter, findings were validated serially in 20 Apc Min mice aged 6, 8, 10, and 12 wk that received standard chow to increase adenoma numbers. In vivo abdominal 18 F-FDG uptake was correlated with microscopy results. Results: Microscopic examination showed that the mice developed 25-35 intestinal adenomas at age 12 wk. Ex vivo 18 F-FDG PET of the dissected intestines visualized all large adenomas and most small adenomas. Ex vivo total intestinal 18 F-FDG uptake correlated with in vivo total abdominal uptake and with the number of large adenomas at age 9 and 12 wk. At 12 wk, there was a clear correlation between in vivo abdominal tracer uptake and the number of large adenomas but not the total number of lesions. Conclusion: Intestinal adenomas in Apc Min mice are metabolically active lesions that take up 18 F-FDG. Abdominal 18 F-FDG uptake at age 12 wk serves as a readout modality for large intestinal adenomas.

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“…The size of the lesion and grade of dysplasia plays a role in the sensitivity. The sensitivity is about 72% for a tumor larger than 1 cm and is about 33% for low grade lesions and 76% for high grade lesions [77,81]. A colonoscopy is warranted when focally increased uptake of FDG is seen in the colon.…”

Section: F-flurodeoxyglucose Positron Emission Tomography (Fdg-pet)mentioning

confidence: 99%

“…Studies have shown that FDG-PET imaging can detect primary carcinomas and premalignant lesions of the large bowel [77][78][79][80][81]. The size of the lesion and grade of dysplasia plays a role in the sensitivity.…”

Section: F-flurodeoxyglucose Positron Emission Tomography (Fdg-pet)mentioning

confidence: 99%

An Overview of Colorectal Cancer Screening

Bhagat¹,

Wanebo²

2015

J Carcinog Mutagen

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2-(¹⁸F)-Fluoro-2-Deoxy-D-Glucose Positron Emission Tomography Detects Clinical Relevant Adenomas of the Colon: A Prospective Study

Abstract: FDG-PET detects colonic adenomas and the diagnostic test characteristics improve with size and grade of dysplasia of the adenoma.

Cited by 83 publications

References 21 publications

Ability of integrated positron emission and computed tomography to detect significant colonic pathology

Ability of integrated positron emission and computed tomography to detect significant colonic pathology

Total Abdominal ¹⁸F-FDG Uptake Reflects Intestinal Adenoma Burden in Apc Mutant Mice

An Overview of Colorectal Cancer Screening

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2-(18F)-Fluoro-2-Deoxy-D-Glucose Positron Emission Tomography Detects Clinical Relevant Adenomas of the Colon: A Prospective Study

Abstract: FDG-PET detects colonic adenomas and the diagnostic test characteristics improve with size and grade of dysplasia of the adenoma.

Cited by 83 publications

References 21 publications

Ability of integrated positron emission and computed tomography to detect significant colonic pathology

Ability of integrated positron emission and computed tomography to detect significant colonic pathology

Total Abdominal 18F-FDG Uptake Reflects Intestinal Adenoma Burden in Apc Mutant Mice

An Overview of Colorectal Cancer Screening

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Product

Resources

About

2-(¹⁸F)-Fluoro-2-Deoxy-D-Glucose Positron Emission Tomography Detects Clinical Relevant Adenomas of the Colon: A Prospective Study

Total Abdominal ¹⁸F-FDG Uptake Reflects Intestinal Adenoma Burden in Apc Mutant Mice