2<sup>nd</sup> line chemotherapy for patients with malignant mesothelioma (MPM) pretreated with pemetrexed (PMTX) and platinum (P)

Karthaus, Meinolf; Frieler, F.; Plahl, A.; Wert, N.; Tagizadeh, K.; Metzner, D.

doi:10.1200/jco.2005.23.16_suppl.7331

Cited by 4 publications

(2 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In pemetrexed-naïve patients, early case study reports including some pretreated patients had provided evidence that additional response was possible following SL chemotherapy [11,[29][30][31]. A few small trials did not demonstrate efficacy, but showed the possibility of recruiting patients with good PS to SL studies [12,14].…”

Section: Discussionmentioning

confidence: 98%

Second-line chemotherapy in malignant pleural mesothelioma: Results of a retrospective multicenter survey

et al. 2012

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 98%

Second-line chemotherapy in malignant pleural mesothelioma: Results of a retrospective multicenter survey

et al. 2012

View full text Add to dashboard Cite

“…Karthaus et al also recently reported a small group of MPM patients pretreated with pemetrexed who received second-line treatment. 28 Other studies of previously treated patients with MPM are summarized in Table 3. Previously treated MPM is notoriously resistant to chemotherapy.…”

Section: Discussionmentioning

confidence: 99%

Pemetrexed Alone or in Combination with Cisplatin in Previously Treated Malignant Pleural Mesothelioma: Outcomes from a Phase IIIB Expanded Access Program

Belani

Keohan

Ross

et al. 2006

Journal of Thoracic Oncology

View full text Add to dashboard Cite

Background: In a randomized phase III trial, pemetrexed plus cisplatin was associated with improved survival compared with cisplatin alone for patients with malignant pleural mesothelioma (MPM). However, there are limited data available on the efficacy of these and other chemotherapy regimens in patients who have received previous systemic chemotherapy. To gather additional efficacy and safety data of pemetrexed/cisplatin and pemetrexed alone in previously treated patients, we examined patients treated on the Eli Lilly and Company expanded access program (EAP). Patients and Methods: Patients with malignant mesothelioma were enrolled in this trial. Of 1056 patients receiving at least one dose of the study drug, 187 (17.7%) were previously treated patients with MPM. Patients were treated every 21 days with pemetrexed 500 mg/m 2 alone (n ϭ 91) or in combination with cisplatin 75 mg/m 2 (n ϭ 96) for a maximum of six cycles. All patients received folic acid and vitamin B12 supplementation and steroid prophylaxis. Serious adverse events (SAEs) were reported by investigators and compiled in a pharmacovigilance database for all patients enrolled in the EAP. Results: Median age of the previously treated pleural mesothelioma subset was 66 years (range, 27-87 years). Based on 153 evaluable patients (a subset of the larger intent-to-treat population of 187), the overall response rate was 32.5% for pemetrexed and cisplatin and 5.5% for pemetrexed alone. The disease control rate (response rate ϩ stable disease) was 68.7% for pemetrexed and cisplatin and 46.6% for pemetrexed alone. Median survival was 7.6 months for pemetrexed plus cisplatin (67% censored) and 4.1 months for pemetrexed alone (55% censored). The most commonly reported serious adverse events in the overall EAP irrespective of causality were dehydration (7.2%), nausea (5.2%), vomiting (4.9%), dyspnea (3.8%), and pulmonary embolism (2.4%). Conclusions:The data from this EAP study suggest that patients with previously treated MPM can benefit from treatment with pemetrexed alone or in combination with cisplatin. The treatment is associated with acceptable toxicity.

show abstract

Second-line treatment for malignant pleural mesothelioma

Ceresoli

Zucali

Gianoncelli

et al. 2010

Cancer Treatment Reviews

View full text Add to dashboard Cite

2^nd line chemotherapy for patients with malignant mesothelioma (MPM) pretreated with pemetrexed (PMTX) and platinum (P)

Cited by 4 publications

References 0 publications

Second-line chemotherapy in malignant pleural mesothelioma: Results of a retrospective multicenter survey

Second-line chemotherapy in malignant pleural mesothelioma: Results of a retrospective multicenter survey

Pemetrexed Alone or in Combination with Cisplatin in Previously Treated Malignant Pleural Mesothelioma: Outcomes from a Phase IIIB Expanded Access Program

Second-line treatment for malignant pleural mesothelioma

Contact Info

Product

Resources

About

2nd line chemotherapy for patients with malignant mesothelioma (MPM) pretreated with pemetrexed (PMTX) and platinum (P)

Cited by 4 publications

References 0 publications

Second-line chemotherapy in malignant pleural mesothelioma: Results of a retrospective multicenter survey

Second-line chemotherapy in malignant pleural mesothelioma: Results of a retrospective multicenter survey

Pemetrexed Alone or in Combination with Cisplatin in Previously Treated Malignant Pleural Mesothelioma: Outcomes from a Phase IIIB Expanded Access Program

Second-line treatment for malignant pleural mesothelioma

Contact Info

Product

Resources

About

2^nd line chemotherapy for patients with malignant mesothelioma (MPM) pretreated with pemetrexed (PMTX) and platinum (P)