The goal of this research is to design, fabricate, and test an amplifier circuit which minimizes the input bias current over the input direct current operating point of the amplifier. A biasing scheme to set the drain-source voltage (V ds ) to null the net gate leakage current of the input transistor is shown. The desired V ds bias is obtained by replicating the V ds of a reference transistor that operates at the same current density as the input transistor and has its gate terminal open-circuited so that the drain-gate leakage and the gate-source leakage must cancel. An implementation of this scheme as a cascode amplifier is described. Measurement results are presented showing > 20× reduced drift rate of a track-and-hold circuit when the output buffer amplifier uses the new approach as compared with a conventional buffer amplifier.