2‐Vinyl quinazoline 3‐oxides; Preparation from acid induced cyclocondensation of 2‐acylaminoaryloximes

Iodine‐Catalyzed, Stereo‐ and Regioselective Synthesis of 4‐Arylidine‐4H‐benzo[d][1,3]oxazines and their Applications for the Synthesis of Quinazoline 3‐Oxides

“…In addition, the synthesized benzoxazines have been exploited as potential precursors for the synthesis of quinazoline 3‐oxides. These quinazoline 3‐oxides were reported as excellent precursors for the construction of various heterocycles of biological importance19 and the synthesis of such derivatives was executed from the corresponding amidoximes by the cyclization method 19…”

Three-Component Heterocyclization of gem-Bromofluorocyclopropanes with NOBF4: Access to 4-Fluoropyrimidine N-Oxides

“…It is worth noting that the major method of synthesis of pyrimidine N -oxides, based on oxidation of corresponding pyrimidines, is complicated by side reactions. , Other existing approaches to pyrimidine N -oxides ,, include the reactions of ring transformations, preferentially of 1,2,4-oxadiazoles or pyrimidinium compounds, ,− and the ring-closure reactions, such as the condensation of amino-containing carbonyl derivatives − and nitriles by the treatment with hydroxylamine; the cyclization of amino oximes with orthoesters, , 1,3-dicarbonyl derivatives, , isothiocyanates or chloroanhydrides; and, less general, the reaction of nitroaromatic compounds with isocyanoacetate. , It is noteworthy that none of ring formation methods was employed to obtain 4-halogenopyrimidine N -oxides.…”