2-Year Follow-Up of Subjects and Their Families Defined as at Risk for Psychopathology on the Basis of Platelet MAO Activities

Coursey, Robert D.; Buchsbaum, Monte S.; Murphy, Dennis L.

doi:10.1159/000117877

Cited by 24 publications

(3 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Subjects who failed to return the mailed impairment inventories after several contacts were asked to complete the index by phone with an interviewer who was blind to their GBI scores. Telephone interviews have been found to be adequate for such purposes in other recent follow-up studies of high-risk samples (Coursey, Buchsbaum, & Murphy, 1982) Equal numbers of cases and noncases completed inventones by phone. Impairment scores of subjects completing the inventory by mail and by phone were similar…”

Section: Impairment Indexmentioning

confidence: 99%

Continued impairment in persons at risk for bipolar affective disorder: Results of a 19-month follow-up study.

Klein¹,

Depue²

1984

Journal of Abnormal Psychology

View full text Add to dashboard Cite

The results of a 19-month follow-up study of persons identified as being at risk for bipolar affective disorder by the General Behavior Inventory (GBI) are reported Forty-five GBI cases and 64 noncase control subjects completed brief inventories reflecting subjects' psychological impairment over the follow-up period Overall, GBI cases continued to exhibit significant impairment relative to control subjects Two cases had been hospitalized for major depressive episodes following suicide attempts In addition, significantly higher proportions of GBI cases (a) were referred for treatment by family or friends, (b) reported frequent suicidal ideation, and (c) frequently considered seeking treatment Recently, we introduced a behavioral high-risk paradigm for the identification of persons at nsk for bipolar affective disorder (Depue et al., 1981) The paradigm focuses on individuals exhibiting subsyndromal bipolar disorder, or cyclothymia-a group which is at increased nsk for developing full syndromal bipolar illness (Akiskal, Djenderedjian, Rosenthal, & Kham, 1977). To identify cyclothymics in the general population, we developed the General Behavior Inventory (GBI), a first-stage case-identification inventory for cyclothymia In a previous article, we presented converging evidence for the validity of the GBI from diagnostic-interview, informant-report, family-history, chnical-characterlstics, and daily behavior-rating studies (Depue et al., 1981). In this article, we present evidence that individuals identified as cases by the inventory continue to exhibit significant impairment over the course of a 19-month follow up Method Subjects Subjects consisted of the 126 nonclmical (undergraduate) subjects who participated in the Depue et al. (1981) studies. A cutoff of 27 on the GBI, which maximized concordance between the mven-

show abstract

Section: Impairment Indexmentioning

confidence: 99%

Continued impairment in persons at risk for bipolar affective disorder: Results of a 19-month follow-up study.

Klein¹,

Depue²

1984

Journal of Abnormal Psychology

View full text Add to dashboard Cite

show abstract

“…16 Evidence is also emerging for a link with smoking 17 and several reports point to an increased incidence of smokers in low MAO groups. 17,18 Low platelet MAO activity also appears to be associated with addiction to alcohol 19 and marihuana. 20 Although it is not difficult to envisage environmental factors providing a stimulus to smoking, there may well be a genetic basis to such a predisposition.…”

Section: Introductionmentioning

confidence: 99%

Migraine and Cluster Headache: Links Between Platelet Monoamine Oxidase Activity, Smoking and Personality

Littlewood¹,

Glover²,

Sandler³

et al. 1984

Headache

View full text Add to dashboard Cite

SYNOPSIS The incidence of smoking in a group of male cluster headache patients (95%) was significantly (P<0.001) greater than in a matched group of male migrainous patients (26%). Both groups had significantly lower platelet monoamine oxidase activity than controls. This finding may be connected genetically with certain personality characteristics, including predisposition to smoke. It is possible that migrainous patients smoke less than those with cluster headache because the process of smoking has a greater tendency to provoke their headache attacks.

show abstract

“…For example, deviant patterns of autonomic functioning have been used in identifying HR subjects for schizophrenia (Mednick, Schulsinger, & Garfinkel, 1975). Low levels of platelet monoamine oxidase (MAO) have been used in identifying HR subjects for schizophrenia, alcoholism, and depression (Coursey, Buchsbaum, & Murphy, 1982;Siever & Coursey, 1985).…”

Section: Biological Risk Approachmentioning

confidence: 99%

Issues and concerns associated with different risk models for eating disorders

Leung

Geller

Katzman

1996

Int. J. Eat. Disord.

View full text Add to dashboard Cite

Objective The present paper examines issues and concerns associated with different risk models in identifying individuals who may be vulnerable for eating disorders. Methods: Studies were located by computerized search and the authors' knowledge of the literature. For the purposes of this paper, different risk models are grouped according to three types of sample selection criteria: exposure to environmental pressures toward thinness, parental psychopathology, and intraindividual characteristics. Intraindividual characteristics were subdivided into biological and behavior vulnerability markers, and within the behavior risk approach, symptom and nonsymptom risk models were further identified. Results: Our literature review indicates that risk research on eating disorders is still in its formative years. More well‐planned prospective risk studies are needed. Conclusion: Among these risk models, the nonsymptom risk approach, which defines risk on the basis of nonsymptom vulnerability markers, represents one of the more promising avenues for future risk research and deserves further exploration. © 1996 John Wiley & Sons, Inc.

show abstract

2-Year Follow-Up of Subjects and Their Families Defined as at Risk for Psychopathology on the Basis of Platelet MAO Activities

Cited by 24 publications

References 7 publications

Continued impairment in persons at risk for bipolar affective disorder: Results of a 19-month follow-up study.

Continued impairment in persons at risk for bipolar affective disorder: Results of a 19-month follow-up study.

Migraine and Cluster Headache: Links Between Platelet Monoamine Oxidase Activity, Smoking and Personality

Issues and concerns associated with different risk models for eating disorders

Contact Info

Product

Resources

About