20-HETE-promoted cerebral blood flow autoregulation is associated with enhanced pericyte contractility

Liu, Yedan; Zhang, Huawei; Wu, Celeste Yc.; Yu, Tina; Fang, Xing; Ryu, Jane J; Zheng, Baoying; Chen, Zongbo; Roman, Richard J.; Fan, Fan

doi:10.1016/j.prostaglandins.2021.106548

Cited by 18 publications

(16 citation statements)

References 110 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…18 According to the morphology of pericytes, they can be divided into ensheathing pericytes (a-SMA+), mesh pericytes, and thin-stranded pericytes. 13,35 Occasionally, some transitional pericytes that are critical for controlling blood flow can also be found in experiments. They are difficult to identify, so assessment of morphology, localization, and molecular features should be performed.…”

Section: Subtypes Of Pericytesmentioning

confidence: 99%

“…13,68 The latest experiments have shown that 20hydroxyeicosatetraenoic acid (20-HETE), an arachidonic acid metabolite, can promote cerebral blood flow autoregulation. 35 This beneficial effect is probably caused by enhanced pericyte contractility. 35 Multiple recent studies have shown that diabetes has a synergistic relationship with aging in destroying the cerebrovascular wall.…”

Section: Pericytes In Brain Diseasesmentioning

confidence: 99%

“…35 This beneficial effect is probably caused by enhanced pericyte contractility. 35 Multiple recent studies have shown that diabetes has a synergistic relationship with aging in destroying the cerebrovascular wall. 34,68 In DM rats, the detachment of pericytes is significantly exacerbated by aging.…”

Section: Pericytes In Brain Diseasesmentioning

confidence: 99%

See 2 more Smart Citations

Role of Pericytes in Diabetic Angiogenesis

Wang

Zang

Zhang

et al. 2022

Journal of Cardiovascular Pharmacology

View full text Add to dashboard Cite

In the context of diabetes mellitus, various pathological changes cause tissue ischemia and hypoxia, which can lead to the compensatory formation of neovascularization. However, disorders of the internal environment and dysfunctions of various cells contribute to the dysfunction of neovascularization. Although the problems of tissue ischemia and hypoxia have been partially solved, neovascularization also causes many negative effects. In the process of small blood vessel renewal, pericytes are extremely important for maintaining the normal growth and maturation of neovascularization. Previously, our understanding of pericytes was very limited, and the function of pericytes was not yet clear. Recently, multiple new functions of pericytes have been identified, affecting various processes in angiogenesis and relating to various diseases. Therefore, the importance of pericytes has gradually become apparent. This article presents the latest research progress on the role of pericytes in diabetic angiogenesis, characterizes pericytes, summarizes various potential therapeutic targets, and highlights research directions for the future treatment of various diabetes-related diseases.

show abstract

Section: Subtypes Of Pericytesmentioning

confidence: 99%

Section: Pericytes In Brain Diseasesmentioning

confidence: 99%

See 1 more Smart Citation

Role of Pericytes in Diabetic Angiogenesis

Wang

Zang

Zhang

et al. 2022

Journal of Cardiovascular Pharmacology

View full text Add to dashboard Cite

show abstract

“…Functional hyperemia is necessary for normal brain function and is deficient in the elderly and AD patients [13]. This process is mediated by smooth muscle cells and pericytes in arterioles and capillaries, respectively [14][15][16]. Recent studies indicated that the hippocampus is more susceptible to neurovascular unit damage than the cortex [17,18].…”

Section: Poor Autoregulation Contributes To Decreased Cbfmentioning

confidence: 99%

“…An additional mechanism that could potentially contribute to capillary stalling is pericyte dysfunction. Pericytes are contractile cells associated with capillaries that play a significant role in regulating CBF [14][15][16][27][28][29]. Pericyte loss and degeneration has been observed in neurodegenerative diseases such as AD and hypertension-and diabetes-related dementia [9,15,16,[30][31][32].…”

Section: Capillary Stalling Contributes To Decreased Cbfmentioning

confidence: 99%

Capillary Stalling: A Mechanism of Decreased Cerebral Blood Flow in AD/ADRD

Crumpler

Roman

Fan

2021

Journal of Experimental Neurology

View full text Add to dashboard Cite

Alzheimer's Disease (AD) and Alzheimer's Disease-Related Dementias (ADRD) are debilitating conditions that are highly associated with aging populations, especially those with comorbidities such as diabetes and hypertension. In addition to the classical pathological findings of AD, such as beta-amyloid (Aβ) accumulation and tau hyperphosphorylation, vascular dysfunction is also associated with the progression of the disease. Vascular dysfunction in AD is associated with decreased cerebral blood flow (CBF). Impaired CBF is an early and persistent symptom of AD/ADRD and is thought to be associated with deficient autoregulation and neurovascular coupling. Another recently elucidated mechanism that contributes to cerebral hypoperfusion is capillary stalling, or the temporary arrest of capillary blood flow usually precipitated by a stalled leukocyte or constriction of actin-containing capillary pericytes. Stalled capillaries are associated with decreased CBF and impaired cognitive performance. AD/ADRD are associated with chronic, low-level inflammation, which contributes to capillary stalling by increased cell adhesion molecules, circulating leukocytes, and reactive oxygen species production. Recent research has shed light on potential targets to decrease capillary stalling in AD mice. Separate inhibition of Ly6G and VEGF-A has been shown to decrease capillary stalling and increase CBF in AD mice. These results suggest that targeting stalled capillaries could influence the outcome of AD and potentially be a target for future therapies.

show abstract