20-hydroxyecdysone reprograms amino acid metabolism to support the metamorphic development of Helicoverpa armigera

Wang, Xiao-Pei; Sun, Siao; Li, Yanxue; Wang, Lin; Dong, Du-Juan; Wang, Jin-Xing; Zhao, Xiao‐Fan

doi:10.1016/j.celrep.2023.112644

Cited by 5 publications

(3 citation statements)

References 70 publications

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“…Fascinatingly, in the pupal fat body, the process is reversed: α-KG is reverted to Glu by GDH-like, an enzyme reinforced by 20E. These findings underscore 20E's significant influence in the metabolic reconfiguration, ensuring a seamless insect metamorphosis [6]. While the steroid hormone 20E is known to increase the expression of calcium release-activated calcium channel modulator 1, thereby inducing apoptosis in the midgut of H. armigera, a contrasting study offers a more nuanced perspective, illustrating that insulin and 20E are involved in a delicate antagonism in modulating PDK1 (phosphoinositide-dependent kinase-1) expression during insect pupation.…”

Section: Regulation In H Armigeramentioning

confidence: 79%

“…It exerts a significant influence on cellular processes such as autophagy and apoptosis, which are essential for the developmental changes that occur during molting [2]. These cellular events are integral to insect development, growth, and survival, especially in species like D. melanogaster (Drosophila melanogaster), B. mori (Bombyx mori), H. armigera (Helicoverpa armigera), and others [3][4][5][6].…”

Section: Introductionmentioning

confidence: 99%

“…Similarly, the malaria vector, Anopheles gambiae, as an Diptera species depends on the processes regulated by 20E for its rapid larval development [16]. On the other hand, in the cotton bollworm, H. armigera, the interplay between 20E and other signaling pathways modulates PCD, which is crucial for its adaptability to diverse environments [6]. Collectively, 20E regulates autophagy, apoptosis, immune function, and the central nervous system, indicating high antioxidant activities and other functions [17].…”

Section: Introductionmentioning

confidence: 99%

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Research Progress on the Regulation of Autophagy and Apoptosis in Insects by Sterol Hormone 20-Hydroxyecdysone

Lin,

Li,

Zheng

et al. 2023

Insects

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20E (20-Hydroxyecdysone) is a central steroid hormone that orchestrates developmental changes and metamorphosis in arthropods. While its molecular mechanisms have been recognized for some time, detailed elucidation has primarily emerged in the past decade. PCD (Programmed cell death), including apoptosis, necrosis, efferocytosis, pyroptosis, ferroptosis, and autophagy, plays a crucial role in regulated cell elimination, which is vital for cells’ development and tissue homeostasis. This review summarizes recent findings on 20E signaling regulated autophagy and apoptosis in insects, including Drosophila melanogaster, Bombyx mori, Helicoverpa armigera, and other species. Firstly, we comprehensively explore the biosynthesis of the sterol hormone 20E and its subsequent signal transduction in various species. Then, we focus on the involvement of 20E in regulating autophagy and apoptosis, elucidating its roles in both developmental contexts and bacterial infection scenarios. Furthermore, our discussion unfolds as a panoramic exposition, where we delve into the fundamental questions with our findings, anchoring them within the grander scheme of our study in insects. Deepening the understanding of 20E-autophagy/apoptosis axis not only underscores the intricate tapestry of endocrine networks, but also offers fresh perspectives on the adaptive mechanisms that have evolved in the face of environmental challenges.

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Section: Regulation In H Armigeramentioning

confidence: 79%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Research Progress on the Regulation of Autophagy and Apoptosis in Insects by Sterol Hormone 20-Hydroxyecdysone

Lin,

Li,

Zheng

et al. 2023

Insects

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Complicated gene network for regulating feeding behavior: novel efficient target for pest management

Zhao,

Yin,

Wang

et al. 2024

Pest Management Science

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Feeding behavior is a fundamental activity for insects, which is essential for their growth, development and reproduction. The regulation of their feeding behavior is a complicated process influenced by a variety of factors, including external stimuli and internal physiological signals. The current review introduces the signaling pathways in brain, gut and fat body involved in insect feeding behavior, and provides a series of target genes for developing RNA pesticides. Additionally, this review summaries the current challenges for the identification and application of functional genes involved in feeding behavior, and finally proposes the future research direction. © 2024 Society of Chemical Industry.

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Metabolomics and microbiome provide new insights into mechanisms of the variations between the larva and adult stages of the Model Beetle Tribolium castaneum (Herbst)

Bi,

Zhang,

2024

Journal of Asia-Pacific Entomology

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20-hydroxyecdysone reprograms amino acid metabolism to support the metamorphic development of Helicoverpa armigera

Cited by 5 publications

References 70 publications

Research Progress on the Regulation of Autophagy and Apoptosis in Insects by Sterol Hormone 20-Hydroxyecdysone

Research Progress on the Regulation of Autophagy and Apoptosis in Insects by Sterol Hormone 20-Hydroxyecdysone

Complicated gene network for regulating feeding behavior: novel efficient target for pest management

Metabolomics and microbiome provide new insights into mechanisms of the variations between the larva and adult stages of the Model Beetle Tribolium castaneum (Herbst)

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