2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference

Levy, Mitchell M.; Fink, Mitchell P.; Marshall, John C.; Abraham, Edward; Angus, Derek C.; Cook, Deborah J.; Cohen, Jonathan; Opal, Steven M.; Vincent, Jean‐Louis; Ramsay, Graham

doi:10.1007/s00134-003-1662-x

Cited by 3,090 publications

(2,810 citation statements)

References 38 publications

Supporting

Mentioning

2,573

Contrasting

Unclassified

217

Order By: Relevance

“…This reflects the third international consensus definition that sepsis is “life-threatening organ dysfunction caused by a dysregulated host response to infection”20 or what the previous sepsis definition conceptualized as “severe sepsis.”14 We did not require explicit sepsis codes because they were not introduced until 2002, after the start of our study.…”

Section: Methodsmentioning

confidence: 99%

“…This definition reflects the concept of non-infectious systemic inflammatory response described in the 1992 and 2001 consensus definitions of sepsis 1113 14…”

Section: Methodsmentioning

confidence: 99%

“…We looked at patients with sepsis compared with three control groups: adults not currently in hospital, patients in hospital with non-sepsis infection, and patients in hospital with an acute sterile inflammatory process. These comparisons allowed us to determine the excess mortality associated with sepsis (including that associated with admission to hospital) and the incremental excess mortality associated with sepsis, beyond what is associated with admission for the two cardinal features of sepsis11 13 14: infection (by comparing sepsis with inflammatory conditions not caused by infection) and inflammation (by comparing sepsis with infections without evidence of inflammatory storm).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Late mortality after sepsis: propensity matched cohort study

Prescott

Osterholzer

Langa

et al. 2016

BMJ

265

214

View full text Add to dashboard Cite

Objectives To determine whether late mortality after sepsis is driven predominantly by pre-existing comorbid disease or is the result of sepsis itself.Deign Observational cohort study.Setting US Health and Retirement Study.Participants 960 patients aged ≥65 (1998-2010) with fee-for-service Medicare coverage who were admitted to hospital with sepsis. Patients were matched to 777 adults not currently in hospital, 788 patients admitted with non-sepsis infection, and 504 patients admitted with acute sterile inflammatory conditions.Main outcome measures Late (31 days to two years) mortality and odds of death at various intervals.Results Sepsis was associated with a 22.1% (95% confidence interval 17.5% to 26.7%) absolute increase in late mortality relative to adults not in hospital, a 10.4% (5.4% to 15.4%) absolute increase relative to patients admitted with non-sepsis infection, and a 16.2% (10.2% to 22.2%) absolute increase relative to patients admitted with sterile inflammatory conditions (P<0.001 for each comparison). Mortality remained higher for at least two years relative to adults not in hospital.Conclusions More than one in five patients who survives sepsis has a late death not explained by health status before sepsis.

show abstract

Section: Methodsmentioning

confidence: 99%

“…This definition reflects the concept of non-infectious systemic inflammatory response described in the 1992 and 2001 consensus definitions of sepsis 1113 14…”

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Late mortality after sepsis: propensity matched cohort study

Prescott

Osterholzer

Langa

et al. 2016

BMJ

265

214

View full text Add to dashboard Cite

show abstract

“…Indeed, the same criteria can be found in non-infectious conditions [20] and may represent an appropriate physiological reaction [21,22]. In 2001 an International Sepsis Definitions conference revisited the SIRS criteria (see Table 2) [23] by expanding the list of possible signs of systemic inflammation in response to infection to the physical and laboratory findings indicative of early organ dysfunction, altered tissue perfusion, and hemodynamic failure, as well.…”

Section: Definition Of Sepsis Syndromementioning

confidence: 99%

“…As oncological patients with sepsis are logically not different from other septic patients, the panel recommends an early diagnosis of sepsis by following the three main steps: Table 3 Infection probability score a (IPS) [51]. [23], be performed as a regular procedure [22]. Another important role of the assessment of SIRS criteria can be the evaluation of patients with local tissue damage or infection.…”

Section: Statements About Monitoring and Diagnosis Of Sepsismentioning

confidence: 99%

Sepsis in head and neck cancer patients treated with chemotherapy and radiation: Literature review and consensus

Mirabile

Numico²,

Russi

et al. 2015

Critical Reviews in Oncology/Hematology

View full text Add to dashboard Cite

The reporting of infection/sepsis in chemo/radiation-treated head and neck cancer patients is sparse and the problem is underestimated. A multidisciplinary group of head and neck cancer specialists from Italy met with the aim of reaching a consensus on a clinical definition and management of infections and sepsis. The Delphi appropriateness method was used for this consensus. External expert reviewers then evaluated the conclusions carefully according to their area of expertise. The paper contains seven clusters of statements about the clinical definition and management of infections and sepsis in head and neck cancer patients, which had a consensus. Furthermore, it offers a review of recent literature in these topics

show abstract

Understanding the Inflammatory Cytokine Response in Pneumonia and Sepsis

Kong²,

et al. 2007

View full text Add to dashboard Cite

Background: Severe sepsis is common and frequently fatal, and community-acquired pneumonia (CAP) is the leading cause. Although severe sepsis is often attributed to uncontrolled and unbalanced inflammation, evidence from humans with infection syndromes across the breadth of disease is lacking. In this study we describe the systemic cytokine response to pneumonia and determine if specific patterns, including the balance of proinflammatory and anti-inflammatory markers, are associated with severe sepsis and death.Methods: This is a cohort study of 1886 subjects hospitalized with CAP through the emergency departments in 28 US academic and community hospitals. We defined severe sepsis as CAP complicated by new-onset organ dysfunction, following international consensus conference criteria. We measured plasma tumor necrosis factor, IL-6 (interleukin 6), and IL-10 levels daily for the first week and weekly thereafter. Our main outcome measures were severe sepsis and 90-day mortality.Results: A total of 583 patients developed severe sepsis (31%), of whom 149 died (26%). Systemic cytokine level Conclusions:The circulating cytokine response to pneumonia is heterogeneous and continues for more than a week after presentation, with considerable overlap between those who do and do not develop severe sepsis. Unbalanced activation is uncommon, and mortality is highest when both proinflammatory and antiinflammatory cytokine levels are high.

show abstract

2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference

Cited by 3,090 publications

References 38 publications

Late mortality after sepsis: propensity matched cohort study

Late mortality after sepsis: propensity matched cohort study

Sepsis in head and neck cancer patients treated with chemotherapy and radiation: Literature review and consensus

Understanding the Inflammatory Cytokine Response in Pneumonia and Sepsis

Contact Info

Product

Resources

About