2001 α-ketoglutarate-dependent KDM6 histone demethylases epigenetically regulate Interferon Stimulated Gene expression in Lupus

Abstract

scores. Numerically more CB-CAPs positive patients had SLE-DAI rash and met SLEDAI renal criteria. There was no difference in medication use or features of polysymptomatic distress such as widespread pain, fatigue, or depression (table 1).Serologic activity emerged as a hallmark of CB-CAPs positivity. CB-CAPs positive patients were more likely to have positive ANA, anti-Sm, anti-U1RNP, anti-RNP70, anti-C1q and anti-phospholipid antibodies than those who were CB-CAPs negative (table 2). Serologic markers of disease activity including elevated levels of anti-dsDNA and decreased C3 or C4 also tracked with CB-CAPs positivity (table 2). Conclusion Narrowing the heterogenous clinical and immunologic features of SLE into endotypical subgroups is a crucial step toward precision medicine and personalized care in SLE. CB-CAPs positive patients represent an important subset of patients who are characterized by greater serologic activity and internal organ pathology. Moreover, the cumulative burden of SLE activity is greater in those with CB-CAPS positivity, as measured by the ACR/EULAR criteria score. CB-CAPs positivity could provide both diagnostic and prognostic information with implications for improved disease monitoring. Further studies are needed to assess the effects of targeted therapeutics and the long-term outcomes of the CB-CAPs positive endotype. Acknowledgements None.