2009 Clinical Practice Guideline for Patients Undergoing Endovascular Repair of Abdominal Aortic Aneurysms (AAA)

Chair, Diane Smith; DeVeaux, Theresa; Dillard, Cindy; Dinsmore, Melissa; Fitzgerald, Karen; Flood, Alyson; Kohlman-Trigoboff, Debra

doi:10.1016/j.jvn.2009.03.003

Cited by 7 publications

(1 citation statement)

References 32 publications

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“…Although effective in preventing rupture, surgical procedure is invasive and associated with a high mortality and morbidity ( 4 ). Endovascular aneurysm repair (EVAR) are minimally invasive interventions, yet they have anatomical and clinical limitations and drawbacks such as endoleaks and graft migrations ( 5 ). Therefore, an alternative that reduces surgical invasion and the risk of rupture is needed.…”

Section: Introductionmentioning

confidence: 99%

Transcriptome sequencing revealed candidate genes relevant to mesenchymal stem cells' role in aortic dissection patients

et al. 2017

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Aortic dissection (AD) results from the imbalance between synthesis and degradation of extracellular matrices in aortic wall, which is characterized by chronic inflammation. Mesenchymal stem cells (MSCs) are known for anti-inflammatory and repairing effects and have therefore been studied for treatment for numerous diseases, including AD. However, it is unclear which genes or signaling pathways contribute to MSCs' role in AD. In the present study, RNA sequencing (RNA-seq) was conducted between MSCs from patients with AS (AD-MSCs) and those from age-matched healthy donors (HD-MSCs). RNA-seq revealed 201 differentially expressed genes (DEGs) under the filter of fold change>2 and P-value <0.05, in which 93 genes were upregulated and 108 downregulated. We selectively verified 9 out of 201 DEGs via reverse transcription-quantitative polymerase chain reaction (RT-qPCR) with an enlarged sample size. The trends of RT-qPCR results were consistent with RNA-seq data. Unsupervised hierarchical clustering of the 9-gene expression profiles enables the division of clinical samples into AD and HD groups. Kyoto Encyclopedia of Genes and Genomes analysis displayed a significant change in adhesion-related signaling pathways in AD-MSCs compared with HD-MSCs, whereas gene ontology analysis demonstrated DEGs were enriched in functions associated with development and morphogenesis, from a functional perspective. The present results indicate that gene expression profiles of AD-MSCs were significantly changed compared with HD-MSCs. These changes are probably associated with MSCs' adhesion capacity and development. These results may provide important insights into the role of MSCs in AD pathogenesis.

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Section: Introductionmentioning

confidence: 99%

Transcriptome sequencing revealed candidate genes relevant to mesenchymal stem cells' role in aortic dissection patients

et al. 2017

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Muse Cells and Aortic Aneurysm

Hosoyama

Saiki

2018

Advances in Experimental Medicine and Biology

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Treatment of Abdominal Aortic Aneurysms: The Role of Endovascular Repair

Gordon¹,

Toursarkissian²

2014

AORN Journal

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Rupture of an abdominal aortic aneurysm (AAA) is a significant cause of mortality in the United States. Often asymptomatic, AAA is considered a silent killer because it frequently remains undiagnosed until the time of rupture or the patient's death. Major risk factors, such as smoking, age, sex, race, and family history of aortic aneurysm, affect the formation of AAAs. National screening recommendations and advancements in treatment modalities during the past 20 years have improved morbidity and mortality, especially with the introduction of stent grafts for endovascular repair of the aorta. Endovascular aneurysm repair is less invasive than open surgical repair. This article describes the major risk factors, pathophysiology, and diagnosis of AAA; patient selection for endovascular repair; common adverse events and complications; and perioperative implications for the patient undergoing endovascular repair of an AAA. Knowing the treatment options for patients with AAA who are at high risk for rupture should allow clinicians to determine the best course of immediate and long-term care. Patients who undergo endovascular repair of an AAA should receive lifelong monitoring for complications, especially endoleaks.

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2009 Clinical Practice Guideline for Patients Undergoing Endovascular Repair of Abdominal Aortic Aneurysms (AAA)

Cited by 7 publications

References 32 publications

Transcriptome sequencing revealed candidate genes relevant to mesenchymal stem cells' role in aortic dissection patients

Transcriptome sequencing revealed candidate genes relevant to mesenchymal stem cells' role in aortic dissection patients

Muse Cells and Aortic Aneurysm

Treatment of Abdominal Aortic Aneurysms: The Role of Endovascular Repair

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