201 Endoscopic variceal ligation versus pharmacologic treatment for primary prophylaxis of variceal bleeding: a randomised study

Abdel-Fattah, Magdy; Rashed, Mohamed A.; Elfakhry, A.A.; Soliman, Mahmoud; Shiha, Gamal

doi:10.1016/s0168-8278(06)80202-3

Cited by 16 publications

(5 citation statements)

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“…One ongoing trial (ISRCTN16334693) had to be excluded (data not yet available). In total, 27 randomized trials (described in 44 references) were included in our analyses 8–10, 17–42 . Six trials were published in abstract form 21, 26–28, 33, 35 .…”

Section: Resultsmentioning

confidence: 99%

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Meta‐analysis: isosorbide‐mononitrate alone or with either beta‐blockers or endoscopic therapy for the management of oesophageal varices

Gluud

Langholz

Krag

2010

Aliment Pharmacol Ther

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Section: Resultsmentioning

confidence: 99%

“…Two meta‐analyses included trials with unclear randomization methods 20, 21, 33 . Excluding these trials from the meta‐analyses did not change the overall conclusions.…”

Section: Resultsmentioning

confidence: 99%

Meta‐analysis: isosorbide‐mononitrate alone or with either beta‐blockers or endoscopic therapy for the management of oesophageal varices

Gluud

Langholz

Krag

2010

Aliment Pharmacol Ther

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“…122 Sixteen trials have compared EBL with b-adrenergic blockers as a first-line option for primary prophylaxis of variceal bleeding. [123][124][125][126][127][128][129][130][131][132][133][134][135][136][137][138] The meta-analysis of these trials shows an advantage of EBL over b-adrenergic blockers in terms of prevention of first bleeding, without differences in mortality (Fig. 5).…”

Section: Patients With Varicesmentioning

confidence: 98%

Portal Hypertension and Gastrointestinal Bleeding

et al. 2008

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Variceal bleeding is one of the most serious complications of portal hypertension. The driving force for the development of varices is an increase in portal pressure. As portal hypertension progresses, varices dilate until they finally rupture and bleed. This sequence of events might be prevented by achieving a sufficient decrease in portal pressure or by acting locally at the varices with endoscopic treatments. This article reviews the rationale for the management of portal hypertension and the current recommendations for the prevention and treatment of variceal bleeding.

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“…15 Sixteen trials have compared EBL with b-blockers as a first-line option for primary prophylaxis of variceal bleeding. [16][17][18][19][20][21][22][23][24][25][26][27][28][29][30][31] A meta-analysis of these trials showed an advantage of EBL over b-blockers in terms of prevention of first bleeding, without differences in mortality, although 6 of these trials are available only in abstract form. When the meta-analysis is restricted to published studies, there is no significant benefit from EBL compared to b-blockers.…”

Section: Prevention Of the First Bleeding Episodementioning

confidence: 99%