2010 ACCF/AHA/AATS/ACR/ASA/SCA/SCAI/SIR/STS/SVM Guidelines for the Diagnosis and Management of Patients With Thoracic Aortic Disease

Hiratzka, Loren F.; Bakris, George L.; Beckman, Joshua A.; Bersin, Robert M.; Carr, Vincent F.; Casey, Donald E.; Eagle, Kim A.; Hermann, Luke; Isselbacher, Eric M.; Kazerooni, Ella A.; Kouchoukos, Nicholas T.; Lytle, Bruce W.; Milewicz, Dianna M.; Reich, David L.; Sen, Souvik; Shinn, Julie A.; Svensson, Lars; Williams, David M.

doi:10.1016/j.jacc.2010.02.015

Cited by 1,319 publications

(465 citation statements)

References 803 publications

(760 reference statements)

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“…The presence of a thoracic aneurysm was determined through imaging modalities using standard definitions of aneurysm [3]. We consider hypertension to be present when the patient is on antihypertensive medications or systolic blood pressure >140mmHg.…”

Section: Accepted Manuscriptmentioning

confidence: 99%

Comparison of surgical repair and percutaneous stent implantation for native coarctation of the aorta in patients >15 years of age

Yeaw

Wijesekera

Sedgwick

et al. 2015

Heart, Lung and Circulation

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Section: Accepted Manuscriptmentioning

confidence: 99%

Comparison of surgical repair and percutaneous stent implantation for native coarctation of the aorta in patients >15 years of age

Yeaw

Wijesekera

Sedgwick

et al. 2015

Heart, Lung and Circulation

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“…2 The annual reported incidence of aortic dissection ranges from 2.5/100,000 3 to as high as 9.1/100,000 and 16.3/100,000 in women and men, respectively. 2 The true incidence is difficult to determine due to frequent misdiagnosis at the time of death.…”

Section: Introductionmentioning

confidence: 99%

“…1 The majority of individuals with thoracic aortic dissection (approximately 93%) are over the age of 40, with a mean age of 63 years. 3 Of the individuals with thoracic aortic aneurysm and dissection (TAAD), some are identified to have an underlying genetic syndrome. Disorders such as Marfan, Loeys-Dietz, Ehlers-Danlos, and Turner syndromes all predispose individuals to medial degeneration of the aorta.…”

Section: Introductionmentioning

confidence: 99%

“…2 Current data suggest nearly 20% of individuals with TAAD who are otherwise physically normal and without an identified genetic syndrome have at least one first-degree relative with TAAD. 3 These 20% of individuals are designated to have familial thoracic aortic aneurysm and dissection (FTAAD). 3 Advances during recent decades have provided insights into the genetic etiology of both syndromic forms of TAAD and nonsyndromic FTAAD.…”

Section: Introductionmentioning

confidence: 99%

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A Post Mortem Assessment of a 25-Year-Old Man with Ascending Aortic Dissection and a Novel MYLK Variant

et al. 2015

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We report on the process of post mortem evaluation and genetic testing following the death of a 25-year-old man due to ascending aortic dissection leading to aortic rupture. Following the negative clinical testing of a 12-gene thoracic aortic aneurysm and dissection panel, research testing revealed a novel c.5732A>T (p.E1911V) variant in exon 34 of the MYLK gene (NM_053025). Two likely pathogenic variants in this gene have been reported previously in individuals with familial thoracic aortic aneurysm and dissection. Given the unclear clinical consequence of the variant found in our proband, we have classified this change as a variant of uncertain significance. In addition to discussing the complexity involved in variant interpretation, we recognize the need for additional research for more accurate MYLK interpretation. Finally, we comment on the unique challenges of post mortem genetic testing.

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“…Since the first report of TEVAR in TAA (13 patients) in 1994, 5 the technique has rapidly evolved and currently is the primary recommendation for treatment of aneurysms of the thoracic aorta. 6 Although until today, no randomized trials of open versus endovascular TEVAR have been performed.…”

Section: Introductionmentioning

confidence: 99%

Strategies for Endovascular Aortic Repair in Aortobronchial and Aortoesophageal Fistulas

Dorweiler

Weigang

Duenschede

et al. 2013

Thorac cardiovasc Surg

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Objective To report our experience of thoracic endovascular aortic repair (TEVAR) for acute bleeding originating from the thoracic aorta in patients with aortobronchial fistula (ABF) or aortoesophageal fistula (AEF). Patients and Methods A total of nine patients (three woman) were treated from September 1995 to March 2012 by TEVAR for ABF (n ¼ 5) and AEF (n ¼ 4). The implants (N ¼ 14) were introduced with fluoroscopic guidance via the aorta (n ¼ 1), the iliac (n ¼ 2), or femoral (n ¼ 11) artery, respectively. Results All aortic lesions could be sealed successfully. Perioperative morbidity was 0% in the ABF group and 50% (2 of 4) in the AEF group and no procedure-related morbidity was noted except one patient who received aortofemoral reconstruction because of iliac occlusive disease. After an overall mean follow-up of 56 months, three patients of the ABF group are alive and well and two patients died of nonrelated cause. Of the AEF group, one patient is alive after 22 months, and one died from metastasized esophageal cancer after 7 months. Conclusion TEVAR is a safe and reliable procedure in the management of ABF. For AEF, TEVAR provides a successful first-line treatment to seal the fistula and control bleeding. However, prognosis is limited by the esophageal lesion and by ongoing mediastinitis/ sepsis.

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2010 ACCF/AHA/AATS/ACR/ASA/SCA/SCAI/SIR/STS/SVM Guidelines for the Diagnosis and Management of Patients With Thoracic Aortic Disease

Cited by 1,319 publications

References 803 publications

Comparison of surgical repair and percutaneous stent implantation for native coarctation of the aorta in patients >15 years of age

Comparison of surgical repair and percutaneous stent implantation for native coarctation of the aorta in patients >15 years of age

A Post Mortem Assessment of a 25-Year-Old Man with Ascending Aortic Dissection and a Novel MYLK Variant

Strategies for Endovascular Aortic Repair in Aortobronchial and Aortoesophageal Fistulas

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