2011 Consensus statement on endomyocardial biopsy from the Association for European Cardiovascular Pathology and the Society for Cardiovascular Pathology

Leone, Ornella; Veinot, John P.; Angelini, Annalisa; Baandrup, Ulrik; Basso, Cristina; Berry, Gerald J.; Bruneval, Patrick; Burke, Margaret; Butany, Jagdish; Calabrese, Fiorella; d’Amati, Giulia; Edwards, William D.; Fallon, John T.; Fishbein, Michael C.; Gallagher, Patrick J.; Halushka, Marc K.; McManus, Bruce M.; Pucci, Angela; Rodríguez, E. René; Saffitz, Jeffrey E.; Sheppard, Mary N.; Steenbergen, Charles; Stone, James R.; Tan, Carmela D.; Thiene, Gaetano; Wal, Allard C. van der; Winters, Gayle L.

doi:10.1016/j.carpath.2011.10.001

Cited by 461 publications

(344 citation statements)

References 188 publications

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“…In previous consensus procedures it was agreed that characteristic storage on electron microscopy (EM) of an affected organ (i.e. heart or kidney) should be considered as the gold standard for FD (Fogo et al 2010;Leone et al 2012;Smid 2014;Van der Tol 2014a, b). The panel is convinced that in the group of patients discussed here (i.e.…”

Section: Pathologymentioning

confidence: 99%

Uncertain Diagnosis of Fabry Disease in Patients with Neuropathic Pain, Angiokeratoma or Cornea Verticillata: Consensus on the Approach to Diagnosis and Follow-Up

et al. 2014

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Introduction: Individuals with neuropathic pain, angiokeratoma (AK) and/or cornea verticillata (CV) may be tested for Fabry disease (FD). Classical FD is characterised by a specific pattern of these features. When a patient presents with a non-specific pattern, the pathogenicity of a variant in the a-galactosidase A (GLA) gene may be unclear. This uncertainty often leads to considerable distress and inappropriate counselling and treatment. We developed a clinical approach for these individuals with an uncertain diagnosis of FD.Materials and Methods: A document was presented to an FD expert panel with background information based on

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Section: Pathologymentioning

confidence: 99%

Uncertain Diagnosis of Fabry Disease in Patients with Neuropathic Pain, Angiokeratoma or Cornea Verticillata: Consensus on the Approach to Diagnosis and Follow-Up

et al. 2014

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“…First, the study population was relatively small; however this reflects the low incidence of the disease. 5 Second, endomyocardial biopsy, which is considered the gold standard for the diagnosis of myocarditis, 32 was not performed; however, all included patients had cMRI findings consistent with AM, in agreement with current criteria. 6 Moreover, according to current guidelines, endomyocardial biopsy is not indicated in patients with suspected AM presenting without heart failure symptoms and preserved LV systolic function.…”

Section: Study Limitationsmentioning

confidence: 79%

Infarct‐like Acute Myocarditis: Relation Between Electrocardiographic Findings and Myocardial Damage as Assessed by Cardiac Magnetic Resonance Imaging

Nucifora¹,

Miani²,

Chiara³

et al. 2012

Clinical Cardiology

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Background: Acute myocarditis (AM) may occasionally have an infarct-like presentation. The aim of the present study was to investigate the relation between electrocardiographic (ECG) findings in this group of patients and myocardial damage assessed by cardiac magnetic resonance imaging (MRI) with the late gadolinium enhancement (LGE) technique. Hypothesis: Myocardial damage may be associated with ECG changes in infarct-like AM. Methods: Forty-one consecutive patients (36 males; mean age, 36 ± 12 years) with diagnosis of AM according to cardiac MRI Lake Louise criteria and infarct-like presentation were included. The relation between site of ST-segment elevation (STE), sum of STE (sumSTE), time to normalization of STE, and development of negative T wave with the extent of LGE (expressed as % of left ventricular mass [%LV LGE]), was evaluated. Results: Most (80%) patients presented with inferolateral STE; mean sumSTE was 5 ± 3 mm. Normalization of STE occurred within 24 hours in 20 (49%) patients. Development of negative T wave occurred in 28 (68%) patients. Cardiac MRI showed LGE in all patients; mean %LV LGE was 9.6 ± 7.2%. Topographic agreement between site of STE and LGE was 68%. At multivariate analysis, sumSTE (β = 0.42, P < 0.001), normalization of STE >24 hours (β = 0.39, P < 0.001), and development of negative T wave (β = 0.49, P < 0.001) were independently related to %LV LGE. Conclusions: Analysis of the site of STE underestimates the extent of myocardial injury among patients with infarct-like myocarditis. However, some ECG features (ie, sumSTE, normalization of STE >24 hours, and development of negative T wave) may help to identify patients with larger areas of myocardial damage.

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“…При наличии воспалительного инфиль-трата и признаков некроза кардиомиоцитов без явных ишемических изменений диагностировали активный миокардит. наличие воспалительной ин-фильтрации без гистологических признаков некро-за кардиомиоцитов расценивалась как погранич-ный миокардит [4]. Морфологическим признаком хронизации воспалительного процесса служило наличие фиброзной ткани в биоптатах миокарда.…”

Section: том 5 №2 / 2018unclassified

Analysis of the Reasons of Later Diagnostics of Myocarditis

Иванова¹,

Титов²,

Митрофанова³

et al. 2018

Transl. med. (Print)

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резюме верификация диагноза «миокардит», несмотря на активное внедрение современных методов обследо-вания, по-прежнему сложна, что приводит не только к поздней постановке заболевания, но и ухудшению прогноза пациентов.Цель настоящего исследования -выявить причины поздней диагностики воспалительных заболева-ний миокарда, оценить факторы, влияющие на течение заболевания, и эффективность проводимой тера-пии у пациентов с морфологически документированным миокардитом. в исследовании приняли участие 50 пациентов с морфологически документированным миокардитом. длительность наблюдения составила 3,5±1,6 года. в 59% случаев диагноз «миокардит» верифициро-ван в сроки, превышающие 6 месяцев от первых клинико-инструментальных проявлений. отдаленный прогноз пациентов в отношении глобальной сократительной способности левого желудочка зависел от сроков верификации диагноза (c² = 6,9; р <0,05) и клинического варианта дебюта миокардита (c² = 13,7; р <0,01). отмечено достоверное ухудшение прогноза пациентов, имеющих в дебюте заболевания клини-ку сердечной недостаточности и нарушения ритма, а также пациентов с поздней диагностикой заболева-ния вследствие ошибочной его трактовки. Сделан вывод о том, что наличие идиопатических нарушений ритма должно рассматриваться как повод для исключения миокардита у пациентов с уже диагностиро-ванными болезнями сердца. доказано улучшение прогноза на фоне комбинированной терапии сердеч-ной недостаточности (иаПФ, бета-адреноблокаторы и диуретики) (c² = 9,28; p <0,01) и приема статинов (c² = 6,04; р <0,05). AbstractThe verification of the diagnosis of "myocarditis", despite the active introduction of modern survey methods, is still complicated, which leads not only to late diagnosis, but also to worsening the prognosis of patients. The purpose of this study was to identify the causes of late diagnosis of inflammatory diseases of the myocardium, evaluate the factors influencing the course of the disease, and the effectiveness of the therapy in patients with morphologically documented myocarditis. The study involved 50 patients with morphologically documented myocarditis. The duration of follow-up was 3.5±1.6 years. In 59% of cases, myocarditis was diagnosed within a period exceeding 6 months of the first clinical and instrumental manifestations. Long-term prognosis of patients with regard to global contractility of the left ventricle depended on the timing of verification of the diagnosis (c² = 6.9, p <0.05) and the clinical variant of the debut of the myocarditis (c² = 13.7, p <0.01). There was a significant deterioration in the prognosis in patients who have a heart failure clinic and rhythm disorders in the onset of the disease, as well as in patients with late diagnosis of the disease due to erroneous treatment. It was concluded that the presence of idiopathic rhythm disturbances should be considered as an excuse for excluding myocarditis in patients with already diagnosed heart diseases. The study proved an improvement in the prognosis on the background of combined therapy for heart failure (ACE...

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2011 Consensus statement on endomyocardial biopsy from the Association for European Cardiovascular Pathology and the Society for Cardiovascular Pathology

Cited by 461 publications

References 188 publications

Uncertain Diagnosis of Fabry Disease in Patients with Neuropathic Pain, Angiokeratoma or Cornea Verticillata: Consensus on the Approach to Diagnosis and Follow-Up

Uncertain Diagnosis of Fabry Disease in Patients with Neuropathic Pain, Angiokeratoma or Cornea Verticillata: Consensus on the Approach to Diagnosis and Follow-Up

Infarct‐like Acute Myocarditis: Relation Between Electrocardiographic Findings and Myocardial Damage as Assessed by Cardiac Magnetic Resonance Imaging

Analysis of the Reasons of Later Diagnostics of Myocarditis

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