2013 UK National Guideline for the management of lymphogranuloma venereum

White, John Albert; O’Farrell, Nigel; Daniels, David

doi:10.1177/0956462413482811

Cited by 54 publications

(31 citation statements)

References 41 publications

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“…LGV treatment requires an extended course of antibiotics over non-LGV C. trachomatis, such that some patients may unnecessarily receive multiple courses of antibiotics; this risks introducing selection pressure for antimicrobial resistance [20]. Clinicians should maintain a high index of suspicion for LGV in HIV-positive MSM with rectal symptoms, and consider treating presumptively for LGV according to national guidelines [21,22].…”

Section: Discussionmentioning

confidence: 99%

Rapid increase in lymphogranuloma venereum in men who have sex with men, United Kingdom, 2003 to September 2015

et al. 2015

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United Kingdom (UK) national data show a sharp increase in diagnoses of lymphogranuloma venereum (LGV) since 2012. Most cases are in men who have sex with men (MSM) living in London, with high rates of co-infection with HIV and other sexually transmitted infections. In light of these data, and the recent finding that one quarter of LGV infections may be asymptomatic, clinicians should be vigilant in testing for LGV, including in asymptomatic HIV-positive MSM.

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Section: Discussionmentioning

confidence: 99%

Rapid increase in lymphogranuloma venereum in men who have sex with men, United Kingdom, 2003 to September 2015

et al. 2015

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“…Currently, most guidelines do not recommend routine testing for urethral LGV, 15 , 16 except for the European International Union against STI LGV guideline. 17 Earlier, we reported 2.1% LGV positivity rate in MSM with a concurrent anorectal LGV infection and a 6.8% urethral LGV positivity in their sexual partners.…”

mentioning

confidence: 99%

Low Prevalence of Urethral Lymphogranuloma Venereum Infections Among Men Who Have Sex With Men: A Prospective Observational Study, Sexually Transmitted Infection Clinic in Amsterdam, the Netherlands

Vrieze¹,

Versteeg²,

Bruisten³

et al. 2017

Sexual Trans Dis

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“…It might also occur in women with rectal exposure. 35 In the recent outbreaks of LGV in MSM in Western Europe, approximately 96% of all cases presented with proctitis; symptoms included rectal pain, anorectal bleeding, mucoid and/or hemopurulent rectal discharge, tenesmus, constipation, and other symptoms of lower gastrointestinal inflammation. However, patients may present to gastroenterologists or colorectal surgeons for persisting symptoms.…”

Section: Clinical Featuresmentioning

confidence: 99%

“…Modern techniques now rely on nucleic acid amplification tests (NAATs) in well-equipped laboratories. 35 The assays have high sensitivity and specificity. C. trachomatis is an intracellular organism, so samples should contain cellular material.…”

Section: Diagnosismentioning

confidence: 99%

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Lymphogranuloma venereum: diagnostic and treatment challenges

Čeović

Gulin

2015

IDR

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Lymphogranuloma venereum is a sexually transmitted disease caused by L1, L2, and L3 serovars of Chlamydia trachomatis. In the last 10 years outbreaks have appeared in North America, Europe, and Australia in the form of proctitis among men who have sex with men. Three stages of disease have been described. The disease in primary stage may go undetected when only a painless papule, pustule, or ulceration appears. The diagnosis is difficult to establish on clinical grounds alone and frequently relies upon either serologic testing, culture, or more recently, nucleic acid amplification testing of direct specimens. A proper treatment regimen cures the infection and prevents further damage to tissues. Lymphogranuloma venereum causes potentially severe infections with possibly irreversible sequels if adequate treatment is not begun promptly. Early and accurate diagnosis is essential. Doxycycline is the drug of choice. Pregnant and lactating women should be treated with erythromycin or azithromycin. Patient must be followed up during the treatment, until disease signs and symptoms have resolved. Repeated testing for syphilis, hepatitis B and C, and HIV to detect early infection should be performed.

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2013 UK National Guideline for the management of lymphogranuloma venereum

Cited by 54 publications

References 41 publications

Rapid increase in lymphogranuloma venereum in men who have sex with men, United Kingdom, 2003 to September 2015

Rapid increase in lymphogranuloma venereum in men who have sex with men, United Kingdom, 2003 to September 2015

Low Prevalence of Urethral Lymphogranuloma Venereum Infections Among Men Who Have Sex With Men: A Prospective Observational Study, Sexually Transmitted Infection Clinic in Amsterdam, the Netherlands

Lymphogranuloma venereum: diagnostic and treatment challenges

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