2016 AAFP Guidelines for the Management of Feline Hyperthyroidism

Carney, Hazel C; Ward, Cynthia R.; Bailey, Steven J; Bruyette, David S.; Dennis, Sonnya; Ferguson, Duncan C.; Hinc, Amy; Rucinsky, A Renee

doi:10.1177/1098612x16643252

Cited by 86 publications

(154 citation statements)

References 82 publications

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“…At concentrations of TT4 ≥ 10 μg/dL (≥128.72 nmol/L) for cats, a significant difference should be expected between the 2 assays. This difference would not be expected to affect assessment of whether or not the patient had hyperthyroidism, but it potentially could affect assessment of treatment efficacy and calculation of radioactive iodine dose . This finding was the result of marked heteroscedasticity and was similar to the results of a recent comparison of CTT4 versus MTT4 in 157 cats .…”

Section: Discussionsupporting

confidence: 64%

“…The diagnosis of hypothyroidism in dogs is complicated by a number of factors including euthyroid sick syndrome, which causes a decrease in the measured serum total thyroxine (TT4) concentration in the presence of non‐thyroidal illness . Euthyroid sick syndrome also may complicate the diagnosis of hyperthyroidism in cats . Radioimmunoassay and chemiluminescent techniques have been validated for measurement of TT4 in dogs and cats .…”

Section: Introductionmentioning

confidence: 99%

“…3,4 Euthyroid sick syndrome also may complicate the diagnosis of hyperthyroidism in cats. 5 Radioimmunoassay and chemiluminescent techniques have been validated for measurement of TT4 in dogs and cats. 6,7 The Microgenics DRI TT4 enzyme immunoassay (EIA) designed for use in humans (MTT4; Microgenics Corporation, Fremont, California) is the assay most commonly used by commercial reference laboratories.…”

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confidence: 99%

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Comparison of 2 assays for measuring serum total thyroxine concentration in dogs and cats

Wolff

Bilbrough

Moore

et al. 2020

Veterinary Internal Medicne

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Background No gold standard assay for serum total thyroxine (TT4) concentration in small animals exists. The Microgenics DRI TT4 (MTT4) assay is used by most reference laboratories. Hypothesis/Objectives IDEXX Catalyst Total T4 (CTT4) and Immulite 2000 TT4 (ITT4) results will agree with MTT4 results. Animals Residual small animal sera were randomized before reanalysis (dogs, CTT4 versus MTT4: n = 176, ITT4 versus MTT4: n = 74; cats, CTT4 versus MTT4: n = 319, ITT4 versus MTT4: n = 79). Methods Validation and method comparison study. Serum TT4 concentration was measured on all analyzers. Pairwise Pearson correlation, cumulative sum linearity test, regression, and Bland‐Altman method were performed. Results CTT4 versus MTT4 in dogs: constant bias (y‐intercept) was 0.10 μg/dL (95% confidence interval [CI], 0.05‐0.15), proportional bias (slope) was 0.86 μg/dL (95% CI, 0.83‐0.89); in cats, constant bias was 0.13 μg/dL (95% CI, 0.08‐0.20) and proportional bias was 1.01 μg/dL (95% CI, 0.98‐1.03), but the test for linearity failed. Bland‐Altman plots identified increasing disagreement with increasing serum TT4 concentrations. ITT4 versus MTT4 in dogs, constant bias was 0.14 μg/dL (95% CI, 0.04‐0.22) and 0.22 μg/dL (95% CI, 0.09‐0.33) for cats; proportional bias was 0.76 (95% CI, 0.72‐0.80) for dogs and 0.71 (95% CI, 0.69‐0.74) for cats. Conclusions and Clinical Importance Differences in CTT4 and MTT4 results affect interpretation at higher serum TT4 concentrations. The ITT4 proportional bias will underestimate serum TT4 concentrations in dogs and cats, compared to MTT4. Serial TT4 measurements should be done using the same assay.

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Section: Discussionsupporting

confidence: 64%

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

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Comparison of 2 assays for measuring serum total thyroxine concentration in dogs and cats

Wolff

Bilbrough

Moore

et al. 2020

Veterinary Internal Medicne

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“…For example, in the case of a feline patient diagnosed with hyperthyroidism, there are several possible approaches to treatment. Those involved may take into account the patient’s known dislike for taking oral medication, therefore excluding one potential treatment option, which involves giving oral medication for life (Carney et al 2016). Such an example suggests how the veterinary profession might derive lessons from the history of informed consent in human medicine, informing and advising the owner to make decisions that promote the best interests of the animal.…”

Section: Conclusion: a Proposal For Equally Weighting Autonomy And Bementioning

confidence: 99%

Reconciling Autonomy and Beneficence in Treatment Decision-Making for Companion Animal Patients

2018

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This article explores how the concept of consent to medical treatment applies in the veterinary context, and aims to evaluate normative justifications for owner consent to treatment of animal patients. We trace the evolution of the test for valid consent in human health decision-making, against a backdrop of increased recognition of the importance of patient rights and a gradual judicial espousal of a doctrine of informed consent grounded in a particular understanding of autonomy. We argue that, notwithstanding the adoption of a similar discourse of informed consent in professional veterinary codes, notions of autonomy and informed consent are not easily transferrable to the veterinary medicine context, given inter alia the tripartite relationship between veterinary professional, owner and animal patient. We suggest that a more appropriate, albeit inexact, analogy may be drawn with paediatric practice which is premised on a similarly tripartite relationship and where decisions must be reached in the best interests of the child. However, acknowledging the legal status of animals as property and how consent to veterinary treatment is predicated on the animal owner’s willingness and ability to pay, we propose that the appropriate response is for veterinary professionals generally to accept the client’s choice, provided this is informed. Yet such client autonomy must be limited where animal welfare concerns exist, so that beneficence continues to play an important role in the veterinary context. We suggest that this ‘middle road’ should be reflected in professional veterinary guidance.

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“…Mudanças no manejo dos gatos desde 1970 até os dias atuais incluindo a alta porcentagem de gatos sem acesso à rua, o aumento da utilização de dietas comerciais e úmidas e maior sobrevida podem influenciar o aumento da prevalência (CARNEY et al, 2016).…”

Section: Fisiologia E Etiologiaunclassified

<b>Avaliação dos conhecimentos básicos de médicos veterinários brasileiros sobre o hipertireoidismo felino</b>

Padin¹

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AGRADECIMENTOSMeus agradecimentos a todos que me ajudaram de alguma forma nessa trajetória. À minha mãe, pela paciência, pela amizade, por toda ajuda e principalmente por sempre acreditar no meu potencial. Muito mais do que eu mesma. Essa conquista também é sua.Ao Thomas, pelo companheirismo, amizade, amor, e por toda ajuda física e emocional que também foi crucial na execução deste trabalho. Além de não permitir que eu desista dos meus sonhos nos momentos mais difíceis. Aos animais; aos que tutelo e aos pacientes que me ensinam todos os dias sobre a arte de clinicar e a arte de amar. Ao Professor Dr. Archivaldo por tornar este sonho possível, por ser uma grande inspiração profissional (tanto clínico como acadêmico) desde a época de graduação. Por toda confiança depositada, pela orientação e paciência. Devo a ele todas as conquistas dentro da especialidade de felinos e da pós graduação. A todos os professores do curso, em especial aos do departamento de clínica médica. À professora Dra. Marcia Mery que também me traz grande inspiração como pesquisadora. Aos meus colegas de pós graduação pela parceria nas aulas e discussões clínicas. Com destaque à Marcela Pimenta que tanto me ajudou, na divulgação dos questionários e no momento final da confecção desta dissertação. E as grandes amigas Fernanda Chicharo e Pamela Backschat. Às veterinárias clínicas do HOVET, Bruna, Vera, Khadine, Denise e em especial à Andrea. Obrigada pela confiança, pelo conhecimento compartilhado e pela amizade. Ao Thom Y, pela inspiração. A CAPES pela ajuda financeira e a bolsa concedida. A todos os veterinários que dispuseram de seu tempo respondendo o questionário desta pesquisa. Sem dúvidas, este trabalho não seria possível sem a colaboração dos mesmos. E a todos aqueles que contribuíram de alguma forma, muito obrigada. "O conhecimento amplia a vida. Conhecer é viver uma arte que a realidade impede desfrutar." Carlos Bernardo Gonzàlez Pecotche RESUMO PADIN, B.R. Avaliação dos conhecimentos básicos de médicos veterinários brasileiros sobre o hipertireoidismo felino. [Evaluate the level of knowledge about hyperthyroidism in cats among the Brazilian veterinary community]. 2018. 105 f. Dissertação (Mestrado em Ciências) -Faculdade de Medicina Veterinária e Zootecnia, Universidade de São Paulo, São Paulo, 2018. O hipertireoidismo é a endocrinopatia mais prevalente em felinos. Sua incidência vem aumentando nos últimos anos em todo mundo embora ainda seja pouco frequente no Brasil. Estudos evidenciam que gatos com manifestações clínicas da endocrinopatia têm baixa suspeição da doença pelos clínicos comparado a prevalência da mesma. Assim, este trabalho objetivou avaliar as opiniões e experiências de médicos veterinários brasileiros acerca da abordagem e manejo de felinos com hipertireoidismo por meio de um questionário com 22 perguntas sobre o tema. Foram respondidos 1113 questionários, onde 535 (48%) dos veterinários disseram realizar a palpação da tireoide em todos os gatos que atendem. Perda de peso (89,2%), hiperatividade (82,8%) e polifagia (...

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2016 AAFP Guidelines for the Management of Feline Hyperthyroidism

Abstract: To help ensure better case outcomes, the Guidelines reflect currently available, evidenced-based knowledge. If research is lacking, or if a consensus does not exist, the expert panel of authors has made recommendations based on their extensive, cumulative clinical experience.

Cited by 86 publications

References 82 publications

Comparison of 2 assays for measuring serum total thyroxine concentration in dogs and cats

Comparison of 2 assays for measuring serum total thyroxine concentration in dogs and cats

Reconciling Autonomy and Beneficence in Treatment Decision-Making for Companion Animal Patients

<b>Avaliação dos conhecimentos básicos de médicos veterinários brasileiros sobre o hipertireoidismo felino</b>

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