2018 Korean Heart Rhythm Society Guidelines for Non-Vitamin K Antagonist Oral Anticoagulants

박예민,; 박형욱,; 이정명,; 박진규,; 이기홍,; 김진배,; 이영수,; 정보영,

doi:10.3904/kjm.2019.94.1.57

Korean J Med

2019

DOI: 10.3904/kjm.2019.94.1.57

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2018 Korean Heart Rhythm Society Guidelines for Non-Vitamin K Antagonist Oral Anticoagulants

박예민 박예민¹,

박형욱 박형욱²,

이정명 이정명³

et al.

Abstract: Non-vitamin K antagonist oral anticoagulants (NOACs) are an alternative to vitamin K antagonists (VKAs) and have emerged as the treatment of choice in Korea. However, several questions remain regarding the optimal use of these agents in specific clinical situations. In this paper we discuss 1) patients with atrial fibrillation (AF) and coronary artery disease, 2) avoiding confusion with NOAC dosing across indications, 3) cardioversion in a patient treated with a NOAC, 4) AF patients who present with acute stro… Show more

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Cited by 5 publications

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“…[19] The electrical properties of the sensors are characterized by their resistance at 25 °C, R 25 , and the thermal constant, B. This is because the sensors show a large resistivity change of −4% °C −1 over a large temperature range in combination with excellent stability.…”

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confidence: 99%

“…[19,24] The dependence of their bulk elec trical properties on processing conditions, dopant composition, and environmental stability has been the subject of extensive studies. [25][26][27] The spinel composition was synthesized according to published procedures and its composition was verified using Xray fluorescence (XRF) (Supporting Information). This composition was reported to exhibit superior stability and resistivity when compared to other NTC ceramics.…”

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confidence: 99%

“…[19,24] A doped Manganese spinel oxide is used in this study, having the composition Mn 1.71 Ni 0.45 Co 0.15 Cu 0.45 Zn 0.24 O 4 . [25,26] The crystal structure of the as prepared powder was analyzed using Xray powder diffraction (XRD) which shows a cubic spinel as the main phase with traces of a tetragonal spinel, NiO, ZnO, and Mn 2 O 3 (Supporting Information). [25][26][27] The spinel composition was synthesized according to published procedures and its composition was verified using Xray fluorescence (XRF) (Supporting Information).…”

mentioning

confidence: 99%

“…A doped Manganese spinel oxide is used in this study, having the composition Mn 1.71 Ni 0.45 Co 0.15 Cu 0.45 Zn 0.24 O 4 . This composition was reported to exhibit superior stability and resistivity when compared to other NTC ceramics . The spinel composition was synthesized according to published procedures and its composition was verified using X‐ray fluorescence (XRF) (Supporting Information) .…”

mentioning

confidence: 99%

“…This composition was reported to exhibit superior stability and resistivity when compared to other NTC ceramics . The spinel composition was synthesized according to published procedures and its composition was verified using X‐ray fluorescence (XRF) (Supporting Information) . The crystal structure of the as‐prepared powder was analyzed using X‐ray powder diffraction (XRD) which shows a cubic spinel as the main phase with traces of a tetragonal spinel, NiO, ZnO, and Mn 2 O 3 (Supporting Information).…”

mentioning

confidence: 99%

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Large‐Area All‐Printed Temperature Sensing Surfaces Using Novel Composite Thermistor Materials

Katerinopoulou

Zalar

Sweelssen

et al. 2018

Adv Elect Materials

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goal, a scalable process for realizing a large number of sensors over large areas with mechanical flexibility is necessary. Printed flexible and stretchable electronics envisage a drastic change in production methods, but more importantly how elec tronics are perceived and implemented. [7] In applications where thin, flexible, and stretchable properties are required, printed sensors detecting a multi tude of para meters represents an elegant solution. [8][9][10][11][12] Accurate measurement of tempera ture is of critical importance. Measuring temporal changes in temperature or spatial temperature gradients is exten sively used in industrial settings as well as for medical applications. Recently there is an increased interest in equipping complex surfaces and shapes with a large number of temperature sensors. [7,13,14] This requires a costefficient route to manufacture thermistor materials over large areas on flexi ble substrates.Thermocouples are the classical instru ment for measuring temperature, where changes in resistance of a metal is used to determine the temperature. The drawback of this method is the limited change in resistance (+0.1% °C −1 ) and the need to compensate for the cold junction temperature, making accurate measurements challenging, costly, and sensitive to artifacts. [15] Resistance temperature detectors (RTDs) represent another Surfaces which can accurately distinguish spatial and temporal changes in temperature are critical for not only flow sensors, microbolometers, process control, but also future applications like electronic skins and soft robotics. Realizing such surfaces requires the deposition of thousands of thermal sensors over large areas, a task ideally suited for printing technologies. Negative temperature coefficient (NTC) ceramics represent the industry standard in temperature sensing due to their high thermal coefficient and excellent stability. A drawback is their complex and high temperature fabrication process and high stiffness, prohibiting their monolithic integration in large area or flexible applications. As a remedy, a printable NTC composite that combines a rapid and scalable all-printed fabrication process with performances that are on par with conventional NTC ceramics is demonstrated. The composite consists of micrometer-sized manganese spinel oxide particles dispersed in a benzocyclobutene matrix. The sensor has a B coefficient of 3500 K, with a 4.0% change in resistance at 25 °C, comparable to bulk ceramics. The selected polymer binder yields a composite exhibiting less than a 1 °C change in resistance to changes in humidity. The sensor's scalability is validated by demonstration of a A4-sized temperature sensing sheet consisting of over 400 sensors.

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confidence: 99%

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confidence: 99%

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confidence: 99%

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confidence: 99%

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Large‐Area All‐Printed Temperature Sensing Surfaces Using Novel Composite Thermistor Materials

Katerinopoulou

Zalar

Sweelssen

et al. 2018

Adv Elect Materials

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Sustainable Robots 4D Printing

Soleimanzadeh,

Rolfe,

Bodaghi

et al. 2023

Advanced Sustainable Systems

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Nature frequently serves as an inspiration for modern robotics innovations that emphasize secure human–machine interaction. However, the advantages of increased automation and digital technology integration conflict with the global environmental objectives. Accordingly, biodegradable soft robots have been proposed for a range of intelligent applications. Biodegradability provides soft robotics with an extraordinary functional advantage for operations involving intelligent shape transformation in response to external stimuli such as heat, pH, and light. Soft robot fabrication using conventional manufacturing techniques is inflexible, time‐consuming, and labor‐intensive. Recent advances in 3D and 4D printing of soft materials and multi‐materials have become the key to enabling the direct manufacture of soft robotics with complex designs and functions. This review comprises a detailed survey of 3D and 4D printing advances in biodegradable soft sensors and actuators (BSSA), which serve as the most prominent parts of each robotic system. In addition, a concise overview of biodegradable materials for the fabrication of 3D‐printed flexible devices with medical along with industrial applications is provided. A complete summary of current additive manufacturing techniques for BSSA is discussed in depth. Moreover, the concept of biodegradable 4D‐printed soft actuators and sensors and biohybrid soft robots is reviewed.

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Detection of Blood Clots Using a Whole Stent as an Active Implantable Biosensor

Kirimi,

Hoare,

Holsgrove

et al. 2024

Advanced Science

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Many cardiovascular problems stem from blockages that form within the vasculature and often treatment includes fitting a stent through percutaneous coronary intervention. This offers a minimally invasive therapy but re‐occlusion through restenosis or thrombosis formation often occurs post‐deployment. Research is ongoing into the creation of smart stents that can detect the occurrence of further problems. In this study, it is shown that selectively metalizing a non‐conductive stent can create a set of electrodes that are capable of detecting a build‐up of material around the stent. The associated increase in electrical impedance across the electrodes is measured, testing the stent with blood clot to mimic thrombosis. It is shown that the device is capable of sensing different amounts of occlusion. The stent can reproducibly sense the presence of clot showing a 16% +/−3% increase in impedance which is sufficient to reliably detect the clot when surrounded by explanted aorta (one sample t‐test, p = 0.009, n = 9). It is demonstrated that this approach can be extended beyond the 3D printed prototypes by showing that it can be applied to a commercially available stent and it is believed that it can be further utilized by other types of medical implants.

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2018 Korean Heart Rhythm Society Guidelines for Non-Vitamin K Antagonist Oral Anticoagulants

Cited by 5 publications

References 170 publications

Large‐Area All‐Printed Temperature Sensing Surfaces Using Novel Composite Thermistor Materials

Large‐Area All‐Printed Temperature Sensing Surfaces Using Novel Composite Thermistor Materials

Sustainable Robots 4D Printing

Detection of Blood Clots Using a Whole Stent as an Active Implantable Biosensor

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