2018 Practice Guidelines for the management of arterial hypertension of the European Society of Cardiology and the European Society of Hypertension

Williams, Bryan; Mancia, Giuseppe; Spiering, Wilko; Rosei, Enrico Agabiti; Azizi, Michel; Burnier, Michel; Clément, Denis; Coca, António; Simone, Giovanni de; Dominiczak, Anna F.; Kahan, Thomas; Mahfoud, Felix; Redón, Josep; Ruilope, Luis; Zanchetti, Alberto; Kerins, Mary; Kjeldsen, Sverre E.; Kreutz, Reinhold; Laurent, Stéphane; Lip, Gregory Y.H.; McManus, Richard; Narkiewicz, Krzysztof; Ruschitzka, Frank; Schmieder, Roland E.; Shlyakhto, Evgeny; Tsioufis, Κonstantinos; Aboyans, Victor; Desormais, Iléana

doi:10.1097/hjh.0000000000001961

Cited by 1,048 publications

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“…Untreated hypertension is an important risk factor in developing heart failure, ischaemic heart disease, stroke, atrial fibrillation, chronic kidney disease and peripheral arterial disease, and it has also been associated with a higher risk of cognitive decline [2]. Hypertension is a common condition with more than one billion people affected worldwide.…”

Section: Introductionmentioning

confidence: 99%

Cardiovascular drug use among people with cognitive impairment living in nursing homes in northern Sweden

Svahn

Lövheim

Isaksson

et al. 2020

Eur J Clin Pharmacol

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The aim of this study was to describe changes in the pattern of cardiovascular agents used in elderly people living in nursing homes between 2007 and 2013. Further, the aim was to analyse the use of cardiovascular drugs in relation to cognitive impairment and associated factors within the same population, where prescription of loop diuretics was used as a proxy for heart failure. Methods Two questionnaire surveys were performed including 2494 people in 2007 and 1654 people in 2013 living in nursing homes in northern Sweden. Data were collected concerning drug use, functioning in activities of daily living (ADL) and cognition, using the Multi-Dimensional Dementia Assessment Scale (MDDAS). The use of different drugs and drug classes among people at four different levels of cognitive function in 2007 and 2013 were compared. Results The proportion of people prescribed ASA and diuretics was significantly lower at all four levels of cognitive function in 2013 compared to 2007. Among people prescribed loop diuretics, the use of angiotensin-converting enzyme inhibitors/ angiotensin II receptor blockers (ACEI/ARBs) increased from 37.8 to 45.6%, β-blockers from 36.0 to 41.8% and warfarin from 4.4 to 11.4%. The use of warfarin, ACEI/ARBs, β-blockers and mineralocorticoid receptor antagonists (MRAs) were less common among individuals with more severe cognitive impairment. Conclusion The results indicate that cardiovascular drug treatment has improved between 2007 and 2013, but there is room for further improvement, especially regarding adherence to guidelines for heart failure. Increasing cognitive impairment had an effect on treatment patterns for heart failure and atrial fibrillation.

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Section: Introductionmentioning

confidence: 99%

Cardiovascular drug use among people with cognitive impairment living in nursing homes in northern Sweden

Svahn

Lövheim

Isaksson

et al. 2020

Eur J Clin Pharmacol

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“…The proportion of participants reaching the recommended guideline targets (The European Society of Cardiology (ESC) [61] and the European Atherosclerosis Society (EAS)) for LDL-cholesterol and triglycerides in the setting of primary CVD prevention was assessed [62].…”

Section: Cardiovascular Risk and Safety Factorsmentioning

confidence: 99%

“…Hypothesis H 3 stated that at least 80% of the sample has plasma lipids values and BP within the recommended target values. The European Society of Cardiology (ESC) and the European Atherosclerosis Society (EAS) [61,62] do not establish target values for total or HDL-cholesterol, but recommend LDL-cholesterol levels below 3 mmol/L and triglycerides levels below 1.7 mmol/L in the primary prevention of CVD. For the total sample, 140 (93%) participants had LDL-cholesterol levels and 146 (97%) participants had triglyceride levels within target values.…”

Section: Main Findingsmentioning

confidence: 99%

Dietary Intakes and Cardiovascular Health of Healthy Adults in Short-, Medium-, and Long-Term Whole-Food Plant-Based Lifestyle Program

Jakše

Jakše²,

Pinter

et al. 2019

Nutrients

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An effective lifestyle strategy to reduce cardiovascular diseases risk (CVD) factors is needed. We examined the effects of a whole-food plant-based (WFPB) lifestyle program on dietary intake and cardiovascular (CV) risk factors in 151 adults (mean 39.6 (SD 12.5) years). Adherence was categorised into short-, medium- and long-term (years: (0.5–<2), (2–<5) and (5–10)), for both genders separately. Dietary intakes were assessed, fasting blood lipids and blood pressure (BP) were measured, and % participants reaching guideline recommended targets for LDL-cholesterol, triglycerides and BP in the primary CVD prevention was assessed. There were no statistically significant differences in intakes of energy and most nutrients among participants (both genders), that were short-, medium- and long term in our program. Diet was mainly composed of unprocessed vegetables/fruits, whole grains, legumes, potatoes, and nuts/seeds. LDL-cholesterol, triglycerides, systolic and diastolic BP were within targets for: 93%, 97%, 88% and 95% participants, respectively. In females (vs. males), total- and HDL-cholesterol were higher (mean): 3.8 (SD 0.7) vs. 3.4 (SD 0.9), p = 0.002 and 1.5 (SD 0.3) vs. 1.1 (SD 0.2) mmol/L, p < 0.001), systolic BP was lower (113 (SD 11) vs. 120 (SD 10) mmHg, p = 0.001), while there was no difference in diastolic BP (71 (SD 9) vs. 72 (SD 8) mmHg, p = 0.143). More females vs. males reached target triglycerides (99% vs. 91%, p = 0.021) and systolic BP (92% vs. 79%, p = 0.046), while similar females and males reached target LDL-cholesterol (94% vs. 91%, p = 0.500) and diastolic BP (93% vs. 100%, p = 0.107). Participation in our WFPB lifestyle program is associated with favourable dietary intakes, safety markers, and CV risk factor profiles.

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“…Increased pulse wave velocity (PWV) is a commonly recognized independent and strong predictor for cardiovascular morbidity and mortality, both in the general population and in individuals with hypertension (Willum-Hansen et al, 2006;Vlachopoulos et al, 2010). According to the European Society of Hypertension (ESH) guidelines, cfPWV values >10 m/s are an indication of subclinical organ damage (Williams et al, 2018); however the interpretation of cfPWV values should always be done with caution as it does not take into account an individual's age and blood pressure category.…”

Section: Introductionmentioning

confidence: 99%

Metabolomic Signature of Early Vascular Aging (EVA) in Hypertension

Polonis

Wawrzyniak

Daghir-Wojtkowiak

et al. 2020

Front. Mol. Biosci.

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Arterial stiffening is a hallmark of early vascular aging (EVA) syndrome and an independent predictor of cardiovascular morbidity and mortality. In this case-control study we sought to identify plasma metabolites associated with EVA syndrome in the setting of hypertension. An untargeted metabolomic approach was used to identify plasma metabolites in an age-, BMI-, and sex-matched groups of EVA (n = 79) and non-EVA (n = 73) individuals with hypertension. After raw data processing and filtration, 497 putative compounds were characterized, out of which 4 were identified as lysophosphaditylcholines (LPCs) [LPC (18:2), LPC (16:0), LPC (18:0), and LPC (18:1)]. A main finding of this study shows that identified LPCs were independently associated with EVA status. Although LPCs have been shown previously to be positively associated with inflammation and atherosclerosis, we observed that hypertensive individuals characterized by 4 down-regulated LPCs had 3.8 times higher risk of EVA compared to those with higher LPC levels (OR = 3.8, 95% CI 1.7-8.5, P < 0.001). Our results provide new insights into a metabolomic phenotype of vascular aging and warrants further investigation of negative association of LPCs with EVA status. This study suggests that LPCs are potential candidates to be considered for further evaluation and validation as predictors of EVA in patients with hypertension.

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2018 Practice Guidelines for the management of arterial hypertension of the European Society of Cardiology and the European Society of Hypertension

Abstract: Professor Zanchetti died during the development of these Guidelines, in March 2018. He contributed fully to the redaction of these Guidelines, as a member of the Guidelines' Task Force and as a section coordinator. He will be sadly missed by colleagues and friends.

Cited by 1,048 publications

References 2 publications

Cardiovascular drug use among people with cognitive impairment living in nursing homes in northern Sweden

Cardiovascular drug use among people with cognitive impairment living in nursing homes in northern Sweden

Dietary Intakes and Cardiovascular Health of Healthy Adults in Short-, Medium-, and Long-Term Whole-Food Plant-Based Lifestyle Program

Metabolomic Signature of Early Vascular Aging (EVA) in Hypertension

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