2019 Novel Coronavirus Infection: Gastrointestinal Manifestations

Samanta, Jayanta; Dhar, Jahnvi; Kochhar, Rakesh

doi:10.1055/s-0040-1712077

Cited by 27 publications

(33 citation statements)

References 41 publications

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“…This leads to viral replication within infected cells, cellular apoptosis activation and release of viral particles which in turn infect adjacent epithelial cells and enterocytes [22]. Also, there is exaggerated infl ammatory response via chemokine and cytokine release with consequent aggregation of infl ammatory cells and damage to the epithelium [21,30].…”

Section: Pathogenesis Of Sars-cov-2 Infectionmentioning

confidence: 99%

“…In patients undergoing antibiotic and/or antiviral therapy, diarrhoea could result from dysbiosis in the intestine induced by these drugs [41]. Also, alterations in respiratory fl ora due to SARS-CoV-2 have been suggested to affect the digestive system via immune regulation thus leading to diarrhoea [30,42]. Nausea and vomiting may be suggested to result [54,55].…”

Section: Clinical Manifestations Of Sars-cov-2 Infectionmentioning

confidence: 99%

“…Ann Cytol Pathol 5(1): 078-083. DOI: https://dx.doi.org/10.17352/acp.000021mechanisms for diarrhoea include malabsorption, intestinal secretion imbalance and enteric nervous system activation resulting from direct virus entry via ACE-2 receptors[30].…”

mentioning

confidence: 99%

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Pathologic basis of coronavirus disease 2019 (COVID-19) – An overview of cellular affinities, pathogenesis, clinical manifestations, autopsy findings and sequelae

Orakpoghenor¹,

Markus²,

Atata³

et al. 2020

Ann Cytol Pathol

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The global terror instigated by coronavirus disease 2019 (COVID-19) cannot be underestimated and the need for drastic measures towards its control cannot be overemphasized. Coronavirus disease 2019 is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) following attachment of the virus to specifi c receptors in the body. The distribution of these specialized receptors in various organs and tissues of the body is responsible for the various clinical presentations associated with the disease after infection. Despite the higher risk of spread of the infection, autopsies have been carried out though with maximum precautionary measures and information provided to further elucidate the extent of damages caused by the disease. Pathologic mechanisms leading to death from COVID-19 include respiratory failure due to surfactant defi ciency and consequent alveolar collapse, cardiac syncope from direct damage to cardiac muscles, peripheral paralysis, cytokine storm and excessive haemorrhage from impaired coagulation. In patients that recover, potential outcomes which could be short-and/or long-term have been recognized. As a means to develop effective control, eradication and prevention strategies, a proper understanding of the mechanisms of SARS-CoV-2 infection will fully ensure a positive breakthrough. Hence, in this article, the pathologic basis of COVID-19 are provided based on extensive literature searches, and proposed mechanisms of pathogenesis, clinical manifestations, autopsy fi ndings and sequelae are being described.

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Section: Pathogenesis Of Sars-cov-2 Infectionmentioning

confidence: 99%

Section: Clinical Manifestations Of Sars-cov-2 Infectionmentioning

confidence: 99%

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Pathologic basis of coronavirus disease 2019 (COVID-19) – An overview of cellular affinities, pathogenesis, clinical manifestations, autopsy findings and sequelae

Orakpoghenor¹,

Markus²,

Atata³

et al. 2020

Ann Cytol Pathol

View full text Add to dashboard Cite

show abstract

“…Patients diagnosed with COVID-19 commonly presents with diarrhoea. Other gastrointestinal symptoms commonly observed include nausea, vomiting, anorexia and abdominal pain 74,75 . One study was carried out in China to investigate the clinical characteristics of patients presenting with COVID-19.…”

Section: Effects On the Endocrine And Reproductive Systemmentioning

confidence: 99%

Angiotensin Converting Enzyme 2 in COVID-19 infections and the implications of COVID-19 on major body systems

Antoine

Seyni-Boureima

et al. 2020

J Adv Intern Med

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COVID-19, caused by the severe acute respiratory syndrome coronavirus (SARS-CoV-2), was first identified in China in late 2019 and since then, this disease has become a pandemic affecting many countries across the globe. Due to this outbreak, many researchers have been diligently investigating this disease for the establishment of better methods of its treatment and control. Evidence from research has led to a plethora of valuable but uncertain information on the modes of transmission of COVID-19 and the mechanisms by which SARS-CoV-2 establishes infections in targeted tissues. It is now better understood that in this disease, SARS-CoV-2 gains entrance into cells by specifically binding ACE-2 (angiotensin-converting enzyme 2); ACE-2 serves as a potential receptor for the virus. The lungs, in addition to many other organs and tissues, express ACE-2 in varying degrees. Therefore, this review will examine the role of ACE-2 in COVID-19 and the secondary effects that COVID-19 has on organs that express ACE-2. To this end, it will assist in establishing the relationship between the ACE-2 receptor and SARS-CoV-2, bringing to the forefront the correlation between the symptomatology presentation, as well as the severity of infections experienced with COVID-19. Given this, it may even provide an avenue for the generation of treatment, or create a platform for the enhanced knowledge of this novel virus, and therefore, control, and maybe unravel the mystery for long term complications.

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“…Samanta et al in a comprehensive review have lucidly presented the GI associations and GI manifestations of Coronavirus. 1 They have done a meticulous job by looking at every aspect including mechanisms of viral entry, the significance of ACE-2 and TMPRSS2 and diarrhea, the impact on natural course of preexisting GI diseases, and the possible methods to break transmission lines.…”

mentioning

confidence: 99%

The Corona Blitzkrieg: The Developed World on its Knees

Ahuja

2020

Journal of Digestive Endoscopy

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2019 Novel Coronavirus Infection: Gastrointestinal Manifestations

Cited by 27 publications

References 41 publications

Pathologic basis of coronavirus disease 2019 (COVID-19) – An overview of cellular affinities, pathogenesis, clinical manifestations, autopsy findings and sequelae

Pathologic basis of coronavirus disease 2019 (COVID-19) – An overview of cellular affinities, pathogenesis, clinical manifestations, autopsy findings and sequelae

Angiotensin Converting Enzyme 2 in COVID-19 infections and the implications of COVID-19 on major body systems

The Corona Blitzkrieg: The Developed World on its Knees

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