201T1 whole-body scintigraphy in patients with malignant melanoma

Brenner, Winfried; Hj, Klomp; Kh, Bohuslavizki; Szonn, Britta; Wolf, H.; Clausen, M.; Henze, Eberhard

doi:10.1097/00006231-199703000-00006

Cited by 5 publications

(2 citation statements)

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“…Der Nachweis des sentinel lymph node und dessen operative Entfernung ist die sensitivste Methode frühzeitig regionäre Lymphknotenmetastasen zu erfassen (12). Die Tl-201 Szintigraphie hat sich in der Verlaufskontrolle als eine sensitive Methode zum Nachweis von Melanommetastasen erwiesen und hat gegenüber anderen Methoden den Vorteil, dass in relativ kurzer Zeit Ganzkörperaufnahmen durchgeführt werden können (6,15). Erste Untersuchungen mit Tc-99m-Sestamibi zeigen ähnlich Ergebnisse (4, 13).…”

Section: Discussionunclassified

Detection of melanoma metastases With Tc-99m-tetrofosmin

Rettenbacher¹,

Koller²,

Kässmann³

et al. 2000

Nuklearmedizin

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Summary Aim: The aim of this study was to evaluate Tc-99mtetrofosmin whole-body imaging in the detection of metastases in patients with malignant melanoma. Methods: In 30 patients with suspected melanoma metastases we performed whole body imaging. After administration of about 600 MBq Tc-99m-tetrofosmin dynamic images up to 10 min were performed in 7 patients (1 image per 10 sec) to evaluate the optimal tracer uptake in the metastases. In all patients whole-body images were performed 5-10 min p. i. using an acquisition time of 5 min per image. The final diagnosis was confirmed by surgical histology in 30 lesions, by computertomogaphy and clinical course in the remaining lesions. Results: Out of 64 melanoma metastases 49 were detected using Tc-99m-tetrofosmin scintigraphy (49 rp., 15 fn.). The overall sensitivity for the detection of malignant lesions was 77%. Referring only to the lymph node metastases, the sensitivity was 87% (26 rp.; 4 fn.). The maximal tracer uptake was reached 1 min after injection, with a slow decrease in the following 10 minutes. The size of the lesions ranged between 0.5 and 7.0 cm and the T/B ratios between 1.3 and 3.0 (mean 1.88). Conclusions: Tc-99m-tetrofosmin whole body imaging is a simple and side-effectless method for the detection of melanoma metastases especially of lymph node metastases. The results are comparable to Tc-99m-sestamibi and TI-201 scintigraphy.

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Section: Discussionunclassified

Detection of melanoma metastases With Tc-99m-tetrofosmin

Rettenbacher¹,

Koller²,

Kässmann³

et al. 2000

Nuklearmedizin

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“…The high melanotic tumor uptake of iodobenzamide in melanoma‐bearing mice has led to the development of series of radioiodinated benzamide compounds as potential melanoma imaging probes 2–8. Owing to the high affinity of [ 123/131 I]iodobenzamide radiotracers toward melanocytes and favorable tissue distribution characteristics, some of these radiotracers were further pursued in melanoma patients and exhibited selective and sensitive detection of melanoma and its metastases 9–13. Lately, a series of [ 123 I]iodonicotinamides were developed and biologically evaluated as potential imaging and staging of metastatic melanoma 14.…”

Section: Introductionmentioning

confidence: 99%

Rapid and efficient synthesis of [¹⁸F]fluoronicotinamides, [¹⁸F]fluoroisonicotinamides and [¹⁸F]fluorobenzamides as potential pet radiopharmaceuticals for melanoma imaging

Jammaz

Al‐Otaibi

Okarvi

et al. 2011

Labelled Comp Radiopharmac

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In an attempt to simplify nucleophilic radiofluorination reactions to be amenable for automation, a series of [18F]fluoronicotinamides, [18F]fluoroisonicotinamides and [18F]fluorobenzamides were synthesized using one‐step synthetic approach involving displacement reactions on trimethylammonium‐nicotinamide, trimethylammonium‐isonicotinamide and trimethylammonium‐benzamide precursors. Based on starting [18F]‐fluoride, radiochemical yields and purities were found to be greater than 90 and 97%, respectively, within 20 min synthesis time and, without high‐performance liquid chromatography purification. This synthetic approach holds great promise as a rapid and simple method for the automated radiofluorination of [18F]fluoronicotinamides, [18F]fluoroisonicotinamides and [18F]fluorobenzamides with high radiochemical yield and very short preparation time. Copyright © 2011 John Wiley & Sons, Ltd.

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