2021
DOI: 10.1159/000517175
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2021 European Thyroid Association Guidelines for the Management of Iodine-Based Contrast Media-Induced Thyroid Dysfunction

Abstract: Given the fact that a large number of radiological examinations using iodine-based contrast media (ICM) are performed in everyday practice, clinicians should be aware of potential ICM-induced thyroid dysfunction (TD). ICM can induce hyperthyroidism (Hyper) or hypothyroidism (Hypo) due to supraphysiological concentrations of iodine in the contrast solution. The prevalence of ICM-induced TD varies from 1 to 15%. ICM-induced Hyper is predominantly found in regions with iodine deficiency and in patients with under… Show more

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Cited by 56 publications
(43 citation statements)
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“…There has been a significant increase in the number of imaging diagnostic examinations utilizing i.v. contrast enhancement in recent years [ 64 , 65 ]. High levels of iodine contained in iodine-based contrast media may lead to thyroid dysfunction according to the Jod–Basedow effect [ 65 , 66 , 67 ].…”
Section: The Effects Of Iodine Deficiency and Excessmentioning
confidence: 99%
See 1 more Smart Citation
“…There has been a significant increase in the number of imaging diagnostic examinations utilizing i.v. contrast enhancement in recent years [ 64 , 65 ]. High levels of iodine contained in iodine-based contrast media may lead to thyroid dysfunction according to the Jod–Basedow effect [ 65 , 66 , 67 ].…”
Section: The Effects Of Iodine Deficiency and Excessmentioning
confidence: 99%
“…contrast enhancement in recent years [ 64 , 65 ]. High levels of iodine contained in iodine-based contrast media may lead to thyroid dysfunction according to the Jod–Basedow effect [ 65 , 66 , 67 ]. The prevalence of both contrast-induced hyper- and hypothyroidism is estimated at 1–15% [ 66 ].…”
Section: The Effects Of Iodine Deficiency and Excessmentioning
confidence: 99%
“…Third, the administration of iodinated contrast agents for imaging techniques can lead to hypothyroidism in predisposed individuals due to a defective escape from the Wolf–Chaikoff effect—a self-regulatory mechanism known to protect the patients against an overload of iodide [ 138 ]. For instance, an incidence of elevated TSH levels of 76.5% has been reported in patients with advanced Hodgkin’s disease following lymphography, persistent for a median period of 3 months [ 54 ].…”
Section: Is There a Distinguishing Feature Of Ir Thyroid Disorders In The Setting Of Hematological Cancers Compared To Solid Tumors That mentioning
confidence: 99%
“…The landscape of THs actions is further complicated by the emerging role of THs metabolites in cancer [ 16 , 17 ]. The clinical relevance of hypothyroidism in patients with solid non-thyroid cancer shares many complex characteristics with hypothyroidism in the general population [ 18 , 19 ], but the former is even more complicated than the latter due to distinct issues arising from the hypothyroidism–cancer association [ 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 ].…”
Section: Introductionmentioning
confidence: 99%
“…A notable number of cancer patients are expected to confront the hypothyroidism–cancer association, given that hypothyroidism constitutes a common adverse effect of innovative anticancer treatments [ 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 ] and diagnostic procedures using iodinated contrast media [ 34 ], which have, currently, revolutionized the standard of cancer care. Hopefully, hypothyroidism that is induced by the administration of iodinated contrast media is not general and is transient, being attributed to the suppression of THs synthesis via the Wolff–Chaikoff mechanism—an effect that lasts only a few weeks.…”
Section: Introductionmentioning
confidence: 99%