2021 Summary of Photobiomodulation Literature

Carroll, James D.

doi:10.1089/photob.2021.0096

Cited by 2 publications

(1 citation statement)

References 44 publications

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“…It was reported as a well-tolerated, safe and effective modality to manage OM related complications (12) owing to its anti-inflammatory (13) and antioxidant capabilities (14) . Furthermore, it has the ability to accelerate healing process through activating mitochondrial-ATP production, the local release of growth factors (15,16) , increased proliferation of fibroblasts (17,18) , improving extracellular matrix production, macrophage stimulation or activation of collagen production (19).…”

Section: Introductionmentioning

confidence: 99%

Clinical and Histopathologic Evaluation of the Effect of Laser Photobiomodulation And Epicatechin in the Treatment of Radiation Induced Oral Mucositis in Rat Model

Elewa

El-ezz

Aboulfotoh

2022

Egyptian Dental Journal

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Aim: This study aimed to determine the early-stage anticytotoxic effects of Ga-Al-As diode laser photobiomodulation (LPBM) and Epicatechin (green tea extract) (GT), either alone or combined, when used to treat induced oral mucositis (OM) in rats.Subjects & Methods: Thirty Wistar rats were included; two of them were sacrificed in the beginning (normal mucosa control). Radiotherapy OM was induced by a fractionated course of oral radiotherapy at a rate of 2 Gy/min bilaterally twice weekly for two weeks. On day 6, four animals were sacrificed to confirm OM induction. The remaining animals (24 rats) were equally assigned into four groups: Control group (CG), Laser group (LG), green tea extract group (GG) and combined group (L+G). They continued for 5 successive days in the 3-test groups. Animal sacrifice has then occurred on day 11. The mucositis degree (MD) was clinically evaluated, the histopathological assessment of tissue changes was applied using (H&E) and Monoclonal cytochrome-c antibody.Results: All treated animals showed a statistically significant difference (P-value ≤ 0.05) than those in CG. The lased animals had a better clinical outcome with a faster healing than GT. The best clinical outcome and healing pattern were shown in (L+G). Conclusion:Ga-Al-As diode laser and Epicatechin produced protection against radiotherapy induced OM through their antioxidant and anti-apoptotic activity effects. Better outcomes were noted in favor of LPBM over GT.

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