2021 Year in Review: Pediatric Mechanical Ventilation

Miller, Andrew G; Scott, Briana

doi:10.4187/respcare.10311

Cited by 1 publication

(2 citation statements)

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“…The CSF-TP levels of the 103 children were 0.93 (0.65-1.50) g/L. The interval from onset to lumbar puncture was 11 (7)(8)(9)(10)(11)(12)(13)(14)(15) days. Compared with the nonrespiratory insufficiency group, the respiratory insufficiency group showed a higher HFGS at admission (p < 0.001), more facial and/or bulbar weakness (p ¼ 0.002), and shorter onset to admission interval (p ¼ 0.017) (►Table 1, ►Figs.…”

Section: Resultsmentioning

confidence: 96%

“… 1 2 Respiratory insufficiency is a potential life-threatening complication of GBS and it is associated with higher incidence of morbidity. 1 2 7 8 Therefore, predicting respiratory insufficiency is necessary for the proper management of children with GBS. The validated predictors of respiratory insufficiency include serum albumin, forced vital capacity (FVC), negative inspiratory force, and the Erasmus GBS Respiratory Insufficiency Scale (EGRIS), as well as rapid disease progression, inability to cough, stand, or raise the head, bulbar dysfunction, bilateral facial weakness, insufficient foot flexion (at the end of immunotherapy), and dystonia.…”

Section: Introductionmentioning

confidence: 99%

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Factors Associated with Respiratory Insufficiency in Children with Guillain–Barré Syndrome

Sun,

Jiang,

Deng

2024

Neuropediatrics

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Objective The risk factors for respiratory insufficiency in children with Guillain–Barré syndrome (GBS) are poorly known. This study aimed to investigate the factors associated with respiratory insufficiency in children with GBS. Methods This retrospective study included children diagnosed with GBS by pediatric neurologists and admitted at the Wuhan Children's Hospital and other hospitals from January 2013 to October 2022. The patients were divided into the respiratory insufficiency and nonrespiratory insufficiency groups according to whether they received assist breathing during treatment. Results The median (interquartile range) age of onset of 103 patients were 5 (3.1–8.5) years, 69 (67%) were male, and 64 (62.1%) had a history of precursor infection. Compared with the nonrespiratory insufficiency group, the respiratory insufficiency group showed more facial and/or bulbar weakness (p = 0.002), a higher Hughes Functional Grading Scale (HFGS) at admission (p < 0.001), and a shorter onset-to-admission interval (p = 0.017). Compared with the acute motor axonal neuropathy (AMAN) subtype, the acute inflammatory demyelinating polyneuropathy (AIDP) subtype showed longer days from onset to lumbar (p = 0.000), lower HFGS at admission (p = 0.04), longer onset-to-admission interval (p = 0.001), and more cranial nerve involvement (p = 0.04). The incidence of respiratory insufficiency between AIDP and AMAN showed no statistical difference (p > 0.05). Conclusion In conclusion, facial and/or bulbar weakness, HFGS at admission, and onset-to-admission interval were associated with the need for respiratory insufficiency and might be useful prognostic markers in children with GBS.

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