2022-RA-1115-ESGO Evaluation of cervical dysplasia with NOVAprep-miR-CERVIX

Abstract

PUB were compared to the postsurgical pathological specimen or follow-up for non-operated tumors. ResultsFrom November 2016 to February 2022, 34 patients were included. Based on surgical specimen (n=23) or follow up (n=11, including 4 metastasis), the final diagnoses were: 11 sarcomas and 23 non-sarcomas including 22 LM and one inflammatory myofibroblastic tumor [JS1] . The median followup was 12 months (IQR: 6-37). The diagnostic accuracy of M-PUB and MCGH-PUB were 94% and 100%. The sensitivity, specificity and Negative Predictive Value of MCGH-PUB were 100%, 100% and 100%. A high GI was significantly associated with malignancy (p<0•001). Genomic analyses allowed correct malignancy upgrade for four tumors after suspicious microscopic examination. There was no PUB complication and no dissemination on the biopsy track. Conclusion MCGH-PUB is safe and accurate to discriminate pre operatively benign tumors from uterine sarcoma.