2073 POSTER Usefulness of imprint cytology and frozen section examination of the sentinel lymph node in patients with breast cancer

Lumachi, Franco; Borsato, Simonetta; Marino, F.; Brunello, Antonella; Scaglione, Donatella; Basso, U.

doi:10.1016/s1359-6349(07)70835-2

Cited by 3 publications

(4 citation statements)

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“…Fulltext reviews were performed and 16 were excluded for the following reasons: did not compare TIC and FSB (n = 10) and insufficient information to calculate TP/TN/FP/FN (n = 6). Finally, 14 studies were included in the metaanalysis [10][11][12][13][14][15][16][17][18][19][20][21][22][23].…”

Section: Literature Searchmentioning

confidence: 99%

A Systematic Review and Meta‐analysis of Touch Imprint Cytology and Frozen Section Biopsy and Their Comparison for Evaluation of Sentinel Lymph Node in Breast Cancer

Bharath

Sharma²,

Yadav³

et al. 2022

World j. surg.

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Introduction Evaluation of axillary lymph nodes after sentinel lymph node biopsy (SLNB) in breast cancer is mostly done by intra-operative frozen section biopsy (FSB) and/ or touch imprint cytology (TIC). In this systematic review and meta-analysis, we have compared the accuracy of the two modalities. Methods PubMed, EMBASE, and Cochrane electronic databases were searched for articles comparing TIC with FSB. Articles were assessed for methodological and reporting quality. The main summary measures were pooled sensitivity, pooled specificity, and diagnostic accuracy using bivariate generalized linear mixed models using random effects. Results Fourteen studies were included. The pooled sensitivity, specificity, and diagnostic accuracy for FSB were 78%, 100%, and 98.57%. For TIC, the pooled sensitivity, specificity, and diagnostic accuracy were 74%, 98%, and 98.37%. For both methods, visual inspection of summary ROC curves and of forest plots did not show significant heterogeneity. Conclusion TIC showed comparable sensitivity, specificity, and accuracy to FSB and hence can be used as its substitute as a rapid and economical test for the detection of axillary lymph node metastasis during SLNB especially in low-resource settings.

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Section: Literature Searchmentioning

confidence: 99%

A Systematic Review and Meta‐analysis of Touch Imprint Cytology and Frozen Section Biopsy and Their Comparison for Evaluation of Sentinel Lymph Node in Breast Cancer

Bharath

Sharma²,

Yadav³

et al. 2022

World j. surg.

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“…One thousand two hundred and thirty‐seven duplicate records were removed. After screening 2631 titles and abstracts and 94 full texts, 61 articles 15,17–26,41–90 proved eligible. The detail of the study selection process is illustrated in Fig.…”

Section: Resultsmentioning

confidence: 99%

Different Imaging Modalities for the Diagnosis of Axillary Lymph Node Metastases in Breast Cancer: A Systematic Review and Network Meta‐Analysis of Diagnostic Test Accuracy

Gao

Gong

et al. 2022

Magnetic Resonance Imaging

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Background: Accurate diagnosis of axillary lymph node metastasis (ALNM) of breast cancer patients is important to guide local and systemic treatment. Purpose: To evaluate the diagnostic performance of different imaging modalities for ALNM in patients with breast cancer. Study Type: Systematic review and network meta-analysis (NMA). Subjects: Sixty-one original articles with 8011 participants. Field Strength: 1.5 T and 3.0 T. Assessment: We used the QUADAS-2 and QUADAS-C tools to assess the risk of bias in eligible studies. The identified articles assessed ultrasonography (US), MRI, mammography, ultrasound elastography (UE), PET, CT, PET/CT, scintimammography, and PET/MRI. Statistical Analysis: We used random-effects conventional meta-analyses and Bayesian network meta-analyses for data analyses. We used sensitivity and specificity, relative sensitivity and specificity, superiority index, and summary receiver operating characteristic curve (SROC) analysis to compare the diagnostic value of different imaging modalities. Results: Sixty-one studies evaluated nine imaging modalities. At patient level, sensitivities of the nine imaging modalities ranged from 0.27 to 0.84 and specificities ranged from 0.84 to 0.95. Patient-based NMA showed that UE had the highest superiority index (5.95) with the highest relative sensitivity of 1.13 (95% confidence interval [CI]: 0.93-1.29) among all imaging methods when compared to US. At lymph node level, MRI had the highest superiority index (6.91) with highest relative sensitivity of 1.13 (95% CI: 1.01-1.23) and highest relative specificity of 1.11 (95% CI: 0.95-1.23) among all imaging methods when compared to US. SROCs also showed that UE and MRI had the largest area under the curve (AUC) at patient level and lymph node level of 0.92 and 0.94, respectively. Data Conclusion: UE and MRI may be superior to other imaging modalities in the diagnosis of ALNM in breast cancer patients at the patient level and the lymph node level, respectively. Further studies are needed to provide high-quality evidence to validate our findings.

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“…It can be utilized in remote or resource-limited areas in the absence of a cryostat machine and also prevents freezing artifacts. [ 6 ]…”

Section: Discussionmentioning

confidence: 99%

“…It is a type of non-exfoliative cytology which not only preserves tissue but also avoids the freezing artifacts giving it an advantage over frozen section examination. [ 6 ] Imprint cytology has been previously used in the evaluation of brain tumors, vertebral lesions, lymphomas, ovarian tumors, and melanomas apart from breast cancers. [ 7 ]…”

Section: Introductionmentioning

confidence: 99%

Efficacy of intraoperative imprint cytology of sentinel lymph node in breast cancer

Yadav,

Ahuja,

Zaheer

et al. 2024

Cytojournal

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Objective: The most important determinant of patient outcome in cases of breast carcinoma is the regional lymph node status. Intraoperative assessment of sentinel lymph nodes (SLNs) allows the surgeon to perform axillary lymph node dissection in the same sitting if required. The commonly performed intraoperative methods for SLN evaluation are touch imprint cytology (TIC) and frozen section. The present study aimed to determine the sensitivity, specificity, and accuracy of TIC with histopathological diagnosis as gold standard. Material and Methods: The lymph nodes sent for intraoperative examination were bisected along the long axis and touched onto clean glass slides followed by Toluidine blue and rapid Papanicolaou staining. The imprints were reviewed and the interpretation was conveyed to the surgeon. Thereafter, the biopsy was fixed in 10% formalin followed by paraffin embedding with hematoxylin and eosin staining. The specificity, sensitivity, diagnostic accuracy, positive predictive value, and negative predictive value were evaluated with histopathological diagnosis as gold standard. Results: A total of 60 patients who underwent resection surgery were included in the study. Majority (36.7%) of patients were in the age group 41–50 years with a mean age of 48.1 ± 10.6 years. There were 54 cases (90%) and 6 cases (10%) of invasive carcinoma of no special type (ductal) and lobular carcinoma, respectively. According to modified Bloom–Richardson scoring, the cases were categorized as Grade 1–6 cases (10%), Grade 2–36 (60%), and Grade 3–18 (30%). The sensitivity and specificity of TIC were 87.5% and 100%, respectively. The diagnostic accuracy of TIC in the diagnosis of metastasis in SLN was 90%. Conclusion: TIC is an easy-to-perform, cost-effective, rapid, and accurate technique for axillary lymph node evaluation, which also overcomes the need for a cryostat.

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2073 POSTER Usefulness of imprint cytology and frozen section examination of the sentinel lymph node in patients with breast cancer

Cited by 3 publications

References 0 publications

A Systematic Review and Meta‐analysis of Touch Imprint Cytology and Frozen Section Biopsy and Their Comparison for Evaluation of Sentinel Lymph Node in Breast Cancer

A Systematic Review and Meta‐analysis of Touch Imprint Cytology and Frozen Section Biopsy and Their Comparison for Evaluation of Sentinel Lymph Node in Breast Cancer

Different Imaging Modalities for the Diagnosis of Axillary Lymph Node Metastases in Breast Cancer: A Systematic Review and Network Meta‐Analysis of Diagnostic Test Accuracy

Efficacy of intraoperative imprint cytology of sentinel lymph node in breast cancer

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