The object of the scientific research is buildings (structures), which requiring the determination of a reliability indicator for their further operation in new operating conditions, the determination of additional loads in the form of (explosions, fires, vibration processes). The solution to such problems is relevant for buildings (structures), which are acquired (leased) by the owner, for their further operation in the new conditions of the technological process associated with the handling, storage, processing and production of fire and explosion hazardous substances (materials). It is important to determine the readiness of buildings (structures) for operation in the new conditions of functioning of the technological process of production, it is proposed to use deterministic, statistical and probabilistic approaches. It is proposed to use a simplified assessment of the safety margin of a building (structure) by yield strengths (for steel elements) and strength (for base materials, load-bearing walls, partitions and ceilings) corresponding to the maximum allowable values for their destruction. The innovative approach is described that allows us to solve the problems of assessing the strength reliability of structural elements of buildings (structures) to obtain guaranteed characteristics of a given margin of safety, its resistance to possible realized effects (explosions, fires, vibration processes)