21: Clinical Risk Factors for the Development of Primary Graft Dysfunction

Lee, J.C.; Kuntz, Catherine; Kawut, Steven M.; Hadjiliadis, Denis; Ahya, Vivek N.; Wille, Keith; Lama, Vibha N.; Ware, Lorraine B.; Orens, J.; Shah, Ashish S.; Weinacker, Ann; Demissie, Ejigayehu; Christie, Jason D.

doi:10.1016/j.healun.2007.11.025

Cited by 10 publications

(7 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…27,28 Recently, Lee et al described an association between elevated mean pulmonary arterial pressures at the time of surgery with grade 3 PGD at 72 hours that was independent of underlying diagnosis. 29 However, these findings do not exclude a unique pathophysiological factor in PAH patients that leads to increased PGD development. Other recipient disease associations with PGD are less consistent.…”

Section: Recipient Risk Factorsmentioning

confidence: 90%

Primary Graft Dysfunction: Definition, Risk Factors, Short- and Long-Term Outcomes

Lee

Christie

Keshavjee

2010

Semin Respir Crit Care Med

128

View full text Add to dashboard Cite

Primary graft dysfunction (PGD) is a form of early lung graft dysfunction that is a major cause of early morbidity and mortality following lung transplantation. Survivors of PGD have decreased long-term lung function and an increased risk of developing bronchiolitis obliterans syndrome (BOS), a manifestation of chronic graft dysfunction. This article reviews the current definition, contributing factors, and guidelines for grading clinical PGD, as well as controversies surrounding them. The current literature examining clinical risk factors for PGD is summarized, as are studies exploring molecular and biochemical markers for PGD prediction and severity. Studies examining the short- and long-term effects of PGD on lung transplant outcomes are reviewed. Lastly, we highlight the emerging concepts in lung transplantation that will potentially impact PGD incidence and outcomes.

show abstract

Section: Recipient Risk Factorsmentioning

confidence: 90%

Primary Graft Dysfunction: Definition, Risk Factors, Short- and Long-Term Outcomes

Lee

Christie

Keshavjee

2010

Semin Respir Crit Care Med

128

View full text Add to dashboard Cite

show abstract

“…However, the studies carried out in this sense suffer a series of limitations, since they are not multicentric, involve small sample sizes, and are not homogeneous since they have been carried out in different periods characterized by different lung transplant management protocols. 20 In relation to the donor, there appears to be a greater incidence of PGD in females, Afro-Americans, and in extreme age intervals. Prolonged mechanical ventilation, hemodynamic instability and aspiration pneumonia have also been associated to the development of PGD.…”

Section: Risk Factorsmentioning

confidence: 99%

“…The presence of pulmonary hypertension prior to transplant or during the surgical process has been related to the development of PGD. 8,20,21 Regarding the surgical technique, different multicenter studies have reported an independent association between the administration of blood products and an increased risk of PGD, though the precise relationship between them is not clear 20,23 (Table 3). …”

Section: Risk Factorsmentioning

confidence: 99%

Primary graft dysfunction after lung transplantation

López

Miñambres

Arista

et al. 2012

Medicina Intensiva (English Edition)

View full text Add to dashboard Cite

“…Este campo despierta mucho interés clínico dado que la identificación de los pacientes más proclives podría facilitar la toma de medidas precoces minimizando los efectos deletéreos que conlleva esta entidad clínica. Sin embargo, los estudios llevados al efecto presentan limitaciones debido a que no son multicéntricos, presentan pequeños tamaños de muestra 20 . Con relación al donante parece que existe mayor incidencia de DPI en el género femenino, la raza negra afroamericana y las edades extremas.…”

Section: Factores De Riesgounclassified

“…La presencia de hipertensión pulmonar previa al trasplante o durante el proceso quirúrgico se ha relacionado con el desarrollo de DPI 8,20,21 .…”

Section: Factores De Riesgounclassified