212: Luteal phase hCG improves outcomes but not pregnancy rates in unexplained recurrent pregnancy loss

Swart, Linda; Holoch, K.; Amalfitano, Katharine; Forstein, David A.; Lessey, Bruce A.

doi:10.1016/j.ajog.2011.10.230

Cited by 1 publication

(1 citation statement)

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“…Swart et al found that hCG supplementation during the mid-secretory phase for RPL women was able to significantly reduce the miscarriage rate [237]. The immunomodulatory effect of hCG was assessed in a cohort study, in which intrauterine infusion of hCG was administrated for infertile women with a decreased rate of FoxP3 + Treg cells in mid-luteal phase.…”

Section: Human Chorionic Gonadotropin (Hcg)mentioning

confidence: 99%

Recent Advances in Immunotherapeutic Approaches for Recurrent Reproductive Failure

Abdolmohammadi-Vahid¹,

Aghebati‐Maleki²,

Ahmadian-Heris³

et al. 2023

IVF Technologies and Infertility - Current Practices and New Perspectives

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Human reproduction is an insufficient process, disturbed by various factors, such as immunologic aberrations of mother. Immunologic abnormalities, including cellular and humoral immunity imbalance, cause dysregulated immune responses against embryo, fetus, and associated components and lack of maternal immunotolerance, which compromise the maintenance of pregnancy. Therefore, evaluation of immunologic parameters, including cellular and humoral immunity assessment (T and B lymphocyte, T helper subtypes, NK cells, cytokines, and autoantibodies), especially in women with a history of pregnancy loss or implantation failure, would help clinicians to manage the disorder and prevent next unfavorable pregnancy outcomes. Moreover, several immunomodulatory approaches have been introduced to modulate the abnormal immunologic responses in patients who experience reproduction failure, especially those diagnosed with immunologic basis. Anticoagulants, corticosteroids, intravenous immunoglobulin, immunosuppressive medications used in inhibition of graft rejection, such as calcineurin inhibitors, recombinant cytokines, and cell therapy approaches, are among these modalities. Here, we discuss the proposed mechanisms of immunologic abnormalities involved in the etiopathogenesis of reproduction disorders, besides the suggested immunologic tests and immunotherapeutic approaches which may be helpful in management of these disorders.

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Section: Human Chorionic Gonadotropin (Hcg)mentioning

confidence: 99%