212 Non-allergic bronchial excitability in chronic bronchitis

Bahous, Joudy; Pineau, Line; Ouimet, G; Cartier, André; Malo, Jean‐Luc

doi:10.1016/0091-6749(83)90336-6

Cited by 21 publications

(23 citation statements)

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“…Increased rates for BHR, sometimes in excess of 50% have been reported in testing of individuals with chronic bronchitis [Ramsdell et al, 1982;Ramsdale et al, 1984;Bahous et al, 1984a;Okayama et al, 1998]; chronic obstructive pulmonary disease [Yan et al, 1985;Greenspon and Parrish, 1988]; and bronchiectasis [Bahous et al, 1984b;Pang et al, 1989;Ip et al, 1991].…”

Section: Chronic Respiratory Conditionsmentioning

confidence: 98%

Interpretation of the “positive” methacholine challenge

Hewitt¹

2008

American J Industrial Med

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Section: Chronic Respiratory Conditionsmentioning

confidence: 98%

Interpretation of the “positive” methacholine challenge

Hewitt¹

2008

American J Industrial Med

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“…Non-specific pharmacologic airway hyperresponsiveness has been observed in smokers [1] and patients with chronic bronchitis [2] and this may be related to mucosal inflammation [3]. Similarly, airway hyperresponsiveness following viral respiratory infections [4,5], allergen [6,7] and ozone exposure [8] is presumed to be associated with airway inflammation.…”

Section: Introductionmentioning

confidence: 98%

Indomethacin inhibits the increased airway responsiveness to histamine following inhalation of C5a des Arg in rabbits

1986

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It has been shown that inhalation of C5a des Arg increases rabbit airway responsiveness to histamine and that this is associated with an influx of neutrophils into the airway walls. This study was undertaken to see if the augmented response to histamine can be blocked by the cyclo-oxygenase inhibitor indomethacin. Spontaneously breathing, anesthetised rabbits were studied in a volume displacement plethysmograph and pulmonary resistance (R1) was measured using the electrical subtraction technique. Histamine does response curves (HDR) were generated by measuring R1 after serial nubulisation of saline and histamine (1, 3, 10, 30 and 100 mg/ml). Aerosols of either saline or C5a des Arg (1.5 ug/ml) were then inhaled by the animals over a time period of 2 min. An HDR was then repeated 4 hours later. In 9 rabbits the inhalation of C5a des Arg resulted in an upward shift of the repeat HDR: the area under the HDR was significantly greater than under the first HDR (p less than 0.05). In 6 rabbits the repeat HDR 4 hours after saline was shifted downwards (N.S.) indicating some degree of tachyphylaxis. When rabbits were pretreated with indomethacin (5 mg/kg i.v.) the repeat HDR following either C5a des Arg (n = 7) or saline (n = 6) were also shifted downwards i.e., the increased airway responsiveness noted after C5a des Arg was abolished. There was no significant difference in baseline saline R1 during the first or second HDR in any group. These results suggest that the increased airway responsiveness following nebulisation of C5a des Arg may be due to release from neutrophils of products of the cyclo-oxygenase pathway.

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“…Many cross-sectional studies reveal an association between chronic obstructive ventilatory impairment and increased airway responsiveness, even among subjects screened to exclude persons with asthma (4)(5)(6)(7)(8). Such findings, however, provide no evidence that increased airway responsiveness predisposes to the development of chronic airflow obstruction, because numerous other explanations for this cross-sectional association exist (9)(10)(11)).…”

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confidence: 99%

A prospective longitudinal study of methacholine airway responsiveness as a predictor of pulmonary-function decline: the Normative Aging Study.

O’Connor¹,

Sparrow²,

Weiss³

1995

Am J Respir Crit Care Med

118

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It has been hypothesized that nonspecific airway hyperresponsiveness is a risk factor for accelerated pulmonary-function decline during aging and the development of chronic airflow obstruction. We tested this hypothesis in a prospective, longitudinal study of 912 middle-aged and older men (median age, 60 yr; range, 41 to 86 yr) participating in the Normative Aging Study (NAS). Subjects underwent methacholine challenge testing and spirometry at the time of a regularly scheduled NAS examination, and follow-up spirometry was performed after a median interval of 3.3 yr. Allergy skin testing with a panel of four aeroallergens (mixed grasses, mixed trees, ragweed, and house dust) was also performed at the initial examination. Methacholine responsiveness was expressed as the dose-response slope (DRS) (i.e., the slope of a line connecting the origin with the last point of the methacholine dose-response plot) in units of percent decline FEV1/mumol methacholine. The relationship of the methacholine DRS to the subsequent rate of annual decline in lung function (FEV1, FVC, and FEV1/FVC) was examined using multiple linear-regression models with the rates of pulmonary-function decline as the outcome variables. After adjusting for age, height, smoking status, and initial level of lung function, the log10 DRS was a significant predictor of the rate of decline of FEV1 (regression coefficient beta = 12.8, p = 0.03) and FEV1/FVC x 100 (beta = 0.506, p = 0.0001), and a borderline significant predictor of FVC (beta = 15.3, p = 0.05).(ABSTRACT TRUNCATED AT 250 WORDS)

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212 Non-allergic bronchial excitability in chronic bronchitis

Cited by 21 publications

References 0 publications

Interpretation of the “positive” methacholine challenge

Interpretation of the “positive” methacholine challenge

Indomethacin inhibits the increased airway responsiveness to histamine following inhalation of C5a des Arg in rabbits

A prospective longitudinal study of methacholine airway responsiveness as a predictor of pulmonary-function decline: the Normative Aging Study.

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