214 On demand use of tramadol, sildenafil, paroxetine or local anesthetics for management of premature ejaculation, a randomized placebo-controlled clinical trial

Gameel, Tarek; Tawfik, Ahmed; Soliman, Mohamed; Elbendary, Mohamed; Abo-Elenen, Mohamed; Tawfik, T.I.; El-Gamasy, Abd El-Naser K.

doi:10.1016/s1569-9056(13)60701-0

Cited by 3 publications

(3 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our search retrieved 1,218 references from which 31 studies were included in this analysis after abstract screening and full-text review [ 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 ] ( Supplement Fig. 1 ).…”

Section: Resultsmentioning

confidence: 99%

Selective Serotonin Re-Uptake Inhibitors for Premature Ejaculation in Adult Men: A Cochrane Systematic Review

Sathianathen

Hwang

Mian

et al. 2022

World J Mens Health

View full text Add to dashboard Cite

Purpose Selective serotonin re-uptake inhibitors (SSRIs) are frequently used to treat premature ejaculation (PE) in men. We performed a Cochrane review to assess the efficacy of SSRI treatment for PE. Materials and Methods We extensively searched a range of databases up to May 2020 and only included randomized controlled trials. Results A total of 31 studies with 8,254 men were included in this analysis. We found that SSRI treatment probably improves self-perceived PE symptoms (defined as a rating of ‘better’ or ‘much better’; risk ratio [RR], 1.92; 95% confidence interval [CI], 1.66–2.23; moderate-certainty evidence) and satisfaction with intercourse (defined as a rating of ‘good’ or ‘very good’; RR, 1.63; 95% CI, 1.42–1.87; moderate-certainty evidence) compared to placebo. Furthermore, SSRI treatment likely improve participants’ self-perceived control over ejaculation (defined as rating of ‘good’ or ‘very good’; RR, 2.29; 95% CI, 1.72–3.05; moderate-certainty evidence) and probably lessens distress (defined as rating of ‘a little bit’ or ‘not at all’) about PE (RR, 1.54; 95% CI, 1.26–1.88; moderate-certainty evidence). SSRI treatment may increase IELT compared to placebo (mean difference, 3.09 minutes higher; 95% CI, 1.94 higher to 4.25 higher; low-certainty evidence). However, SSRIs may increase treatment cessations due to adverse events compared to placebo (RR, 3.80; 95% CI, 2.61–5.51; low-certainty evidence). Conclusions SSRI treatment for PE appears to substantially improve a number of outcomes of direct patient importance such as symptom improvement, satisfaction with intercourse and perceived control over ejaculation when compared to placebo.

show abstract

Section: Resultsmentioning

confidence: 99%

Selective Serotonin Re-Uptake Inhibitors for Premature Ejaculation in Adult Men: A Cochrane Systematic Review

Sathianathen

Hwang

Mian

et al. 2022

World J Mens Health

View full text Add to dashboard Cite

show abstract

“…Sample size was calculated using G power program version 3.0.10 for windows using results published by Pryor et al (2006) and Gameel et al (2013) with the post‐treatment IELT score as the primary outcome. Patients will be treated using oral dapoxetine 60 mg or topical lidocaine 10% spray, and IELT score will be recorded and compared with the pre‐treatment values.…”

Section: Methodsmentioning

confidence: 99%

“…Different formulas and concentrations of topical anaesthetics were used with variable increases in the recorded IELT. Among these formulas are eutectic mixtures of local anaesthetic cream containing lidocaine and prilocaine (Atikeler, Gecit, & Senol, 2002; Busato & Galindo, 2004; Xia et al, 2014), topical eutectic‐like mixture spray containing lidocaine and prilocaine (Carson & Wyllie, 2010; Dinsmore et al, 2007; Dinsmore & Wyllie, 2009), lidocaine gel (Gameel et al, 2013), lidocaine spray (Dell’Atti, Galosi, & Ippolito, 2017; Steggall, Fowler, & Pryce, 2008) and fortacin (Porst & Burri, 2017, 2019). In their meta‐analysis, Jian et al (2018) showed a success rate of 90% of using topical anaesthetics in improving the IELT in PE cases.…”

Section: Introductionmentioning

confidence: 99%

Oral dapoxetine versus topical lidocaine as on‐demand treatment for lifelong premature ejaculation: A randomised controlled trial

et al. 2020

View full text Add to dashboard Cite

This trial aimed to assess the efficacy of on‐demand oral dapoxetine versus topical lidocaine treatments for lifelong PE. Cases with lifelong PE were randomised to start treatment by oral dapoxetine 60 mg or topical lidocaine 10% spray. The intravaginal ejaculatory latency time (ILET), validated Arabic Index for PE (AIPE), Sexual Health Inventory for Men (SHIM) and frequency of intercourse/week were recorded at the baseline and after 12 weeks treatment period of the first medication before two weeks washout period and then crossing over to the other one for another 12 weeks. Results showed that both medications significantly increased both IELT and AIPE scores compared with the baseline being significantly better with topical lidocaine (63.44 s, 179.4 s versus 21.87 s, p < .05). Significant decrease of SHIM score was recorded with lidocaine but not with dapoxetine. Global Efficacy Question for the patient's assessment of the effectiveness of drugs showed that lidocaine was described as being effective by 43 cases and ineffective by 12 cases, oral dapoxetine was described as being effective by 16 cases and ineffective by 39 cases. From these accumulated data, it is concluded that topical lidocaine is more effective on‐demand therapy for lifelong PE compared with oral dapoxetine.

show abstract

Selective serotonin re-uptake inhibitors for premature ejaculation in adult men

Sathianathen

Hwang

Mian

et al. 2021

Cochrane Database of Systematic Reviews

View full text Add to dashboard Cite

214 On demand use of tramadol, sildenafil, paroxetine or local anesthetics for management of premature ejaculation, a randomized placebo-controlled clinical trial

Cited by 3 publications

References 0 publications

Selective Serotonin Re-Uptake Inhibitors for Premature Ejaculation in Adult Men: A Cochrane Systematic Review

Selective Serotonin Re-Uptake Inhibitors for Premature Ejaculation in Adult Men: A Cochrane Systematic Review

Oral dapoxetine versus topical lidocaine as on‐demand treatment for lifelong premature ejaculation: A randomised controlled trial

Selective serotonin re-uptake inhibitors for premature ejaculation in adult men

Contact Info

Product

Resources

About