218 Cystic fibrosis sputum induction trial (CF-SpIT). Tolerability data for induced sputum sampling in children with cystic fibrosis

Tame, J.; Ronchetti, Katherine; Doull, Iolo; Forton, Julian

doi:10.1016/s1569-1993(13)60359-8

Cited by 1 publication

(2 citation statements)

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“…-Induced sputum has been proposed as a sensitive method for use in preschool aged children. 13 However, young children under the age of 6 years are typically unable to expectorate and hence require oropharyngeal suctioning to obtain an induced sputum sample. Sputum samples obtained by induction in this age group are superior to an oropharyngeal swab in young children with CF 14 but have very modest sensitivity and specificity compared to bronchoalveolar lavage 15 and risk false positive cultures due to contamination from the upper airway.…”

Section: Diagnosis Of Tuberculosis (Tb)mentioning

confidence: 99%

“… ‐Sputum induction reduces the need for bronchoscopy in school‐aged children with CF 10 but is not always sensitive for lower airway infection 11 . Sputum‐induction can potentially be performed at home in children older than 5 years, 12 provided previous tolerance to and safety of hypertonic saline has been determined in the child. ‐Induced sputum has been proposed as a sensitive method for use in preschool aged children 13 . However, young children under the age of 6 years are typically unable to expectorate and hence require oropharyngeal suctioning to obtain an induced sputum sample.…”

Section: Indications For Sputum Inductionmentioning

confidence: 99%

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Thoracic Society of Australia and New Zealand position statement: The safe clinical use of sputum induction for bio‐sampling of the lower airways in children and adults

Schultz,

Balaguruswamy,

Dentice

et al. 2024

Respirology

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Sputum induction is widely used in clinical settings for collection of biological samples from the lower airways. However, in recent years sputum induction has been associated with serious adverse events and even death. This position statement was commissioned by the Thoracic Society of Australia and New Zealand to address major adverse events of two deaths associated with sputum induction that have occurred in Australia in 2021, and outlines best practice for the safe use of sputum induction. The statement resulted from systematic literature searches by a multi‐disciplinary group including respiratory physicians, nurses and physiotherapists (paediatric and adults focused). Consumers had input to an advanced draft of the position statement. The position statement covers indications for sputum induction, informed consent, scope of practice of personnel administering the procedure, infection control considerations, details about the sputum induction procedure, safety considerations and risk assessment in clinical settings.image

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Section: Diagnosis Of Tuberculosis (Tb)mentioning

confidence: 99%