22-year trends in dysglycemia and body mass index: A population-based cohort study in Savitaipale, Finland

Saramies, Jouko; Koiranen, Markku; Auvinen, Juha; Uusitalo, Hannu; Hussi, Esko; Cederberg, Henna; Keinänen‐Kiukaanniemi, Sirkka; Tuomilehto, Jaakko

doi:10.1016/j.pcd.2021.09.010

Cited by 6 publications

(5 citation statements)

References 47 publications

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“…The data include questionnaire, clinical, and laboratory assessments as well as data from several national health and population registers. The study population and selection criteria were previously described in detail [ 17 ]. Participants with incomplete glucose data ( n = 17) were excluded, yielding a baseline study sample of 1151 participants.…”

Section: Methodsmentioning

confidence: 99%

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Elevated One-Hour Post-Load Glucose Is Independently Associated with Albuminuria: A Cross-Sectional Population Study

Saunajoki

Auvinen

Bloigu

et al. 2022

JCM

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The purpose of this study was to examine and compare the associations between albuminuria and fasting (FPG), 1 h post-load (1 h PG) and 2 h post-load plasma glucose (2 h PG) in an oral glucose tolerance test (OGTT). A total of 496 people free of known diabetes (mean age 72 years) participated in the examinations including the OGTT with plasma glucose measurements at 0, 1, and 2 h and levels of HbA1c. Albuminuria was determined by the urinary albumin-to-creatinine ratio and was defined as ≥3.0 mg/mmol. Compared with those without albuminuria, participants with albuminuria had significantly higher 1 h PG and 2 h PG levels, but not FPG or HbA1c levels. An elevated 1 h PG increased the estimated odds ratio of albuminuria more than three times in people with prediabetic 1 h PG (8.6–11.5 mmol/L: OR 3.60; 95% CI 1.70–7.64) and diabetic 1 h PG (≥11.6 mmol/L: OR 3.05; 95% CI 1.29–7.23). After adjusting for blood pressure and age, the association of elevated 1 h PG with albuminuria remained significant. Prediabetic or diabetic FPG, 2 h PG, or HbA1c did not have a statistically significant association with albuminuria. These findings suggest that 1 h PG seems to be the best glycemic parameter and is useful in recognizing persons with an elevated risk of early kidney disease due to hyperglycemia.

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Section: Methodsmentioning

confidence: 99%

“…Albuminuria was determined by the urinary albumin-to-creatinine ratio (U-Alb/Crea) from a random spot urine collection and was defined as ≥3.0 mg/mmol [ 22 ]. Plasma total cholesterol, triglycerides, high-density lipoprotein (HDL) and low-density lipoprotein (LDL) were determined as previously described [ 17 ].…”

Section: Methodsmentioning

confidence: 99%

Elevated One-Hour Post-Load Glucose Is Independently Associated with Albuminuria: A Cross-Sectional Population Study

Saunajoki

Auvinen

Bloigu

et al. 2022

JCM

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“…The study design has previously been described in detail [19]. The study design has previously been described in detail [19].…”

Section: Methodsmentioning

confidence: 99%

A Natural History of Erectile Dysfunction in Elderly Men: A Population-Based, Twelve-Year Prospective Study

Saramies

Koiranen

Auvinen

et al. 2022

JCM

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There is a wide variation in the development and course of erectile dysfunction (ED) in men, which confirms the need for prospective studies. We conducted a cross-sectional analysis among the general male population at the baseline (n = 359) and in a follow-up survey (n = 218) 12 years later. The prospective 12-year study included 189 men. ED was assessed using the International Index of Erectile Function questionnaire. The mean age of the participants was 62.0 years at the baseline, while at the 12-year follow-up it was 71.6 years. The crude prevalence of ED was 61.6% at the baseline and 78.9% at the follow-up, and the prevalence tended to increase with age. All of the men aged 75 years or more had at least mild ED. The incidence of ED in every thousand person years was 53.5. A total of 54.5% of the men experienced ED progression, while 39.2% reported no changes in erectile function, and 6.3% experienced ED regression during the 12-year study. The likelihood of ED progression was higher in the older compared with younger age group (odds ratio, OR 5.2 (95% CI: 1.1–26.2)), and the likelihood of ED regression was lower among men with increased depression symptoms (OR 0.3 (95% CI: 0.1–0.6)) and among men with a decreased interest in their sexual life (OR 0.1 (95% CI: 0.0–0.6)). Lifestyle factors such as the consumption of alcohol and smoking were not significantly associated with ED.

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“…Further details of the study design have been recently published (Saramies et al. 2021 ). Written informed consent was obtained from participants before the study.…”

Section: Methodsmentioning

confidence: 99%

“…In the final 22year follow-up visit in 2018-2019, the target population consisted of 906 participants, and of these, 704 participated in the follow-up clinical examinations and 601 participated also in the ophthalmic examination, which is the focus of this study. Further details of the study design have been recently published (Saramies et al 2021). Written informed consent was obtained from participants before the study.…”

Section: Study Structure and Participantsmentioning

confidence: 99%

Ocular surface health of the Finnish elderly population

Aapola

Nättinen

Suurkuukka

et al. 2022

Acta Ophthalmologica

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Purpose: The aim of this study was to describe the clinical ocular surface characteristics in a population-based sample of Finnish elderly people. Methods: This cross-sectional study included 601 subjects (335 females, 266 males) born between the years 1933-1956 and living in Savitaipale, Finland. Ocular surface health was evaluated using a comprehensive set of diagnostic tests. Previous dry eye (DE) diagnosis and history of drug treatment of DE were also recorded. Differences between sexes were estimated with Wilcoxon rank sum test and Fisher's exact test. Results: Overall, 10% and 33% of people displayed signs of DE and ocular surface disease (OSD), respectively, and 30% had been previously diagnosed with DE and 36% used some form of drugs for DE. Men displayed more severe signs of meibomian gland dysfunction, blepharitis and conjunctival redness (p < 0.001), while women had higher scores in corneal staining (p = 0.005) and OSD Index (p < 0.001). Conclusion: Signs of OSD and DE are common among the Finnish elderly population. However, the diagnosis is affected by the diagnostic criteria used and significant differences exist between sexes. Although women were more frequently diagnosed with DE and OSD and experienced more ocular surface irritation, men had more often lid and meibomian glandrelated issues. The current diagnostic criteria of DE pose a risk of misclassifying men, who commonly display less severe symptoms in comparison with women yet exhibit more severe clinical signs associated especially with the lid margin.

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22-year trends in dysglycemia and body mass index: A population-based cohort study in Savitaipale, Finland

Cited by 6 publications

References 47 publications

Elevated One-Hour Post-Load Glucose Is Independently Associated with Albuminuria: A Cross-Sectional Population Study

Elevated One-Hour Post-Load Glucose Is Independently Associated with Albuminuria: A Cross-Sectional Population Study

A Natural History of Erectile Dysfunction in Elderly Men: A Population-Based, Twelve-Year Prospective Study

Ocular surface health of the Finnish elderly population

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