221. Miro resin. Part I. Ferruginol

Aromatic abietane diterpenoids: total syntheses and synthetic studies

“…Some are commercially available as for example, abietic acid (1), dehydroabietic acid (2) (Fig. 1), podocarpic acid (5), sclareol (6) and agathic acid (7) (Fig. 2).…”

“…7 Ferruginol (3) was firstly isolated in 1939 from the resin of the Miro tree (Podocarpus ferrugineus), endemic to New Zealand. 6 Since the isolation of these compounds in the late 1930s, numerous research groups have embarked on their synthesis and the synthesis of related congeners.…”

“…1) which were discovered more than seventy years ago. 5,6 Both structures were assigned based on chemical data. Dehydroabietic acid (2) was initially obtained from chemical studies starting from abietic acid (1), later, it was found in resin or extracts of conifers.…”

The Chemistry of the Order Cupressales

“…From the leaves of several Cupressales HARTWELL (II2,d. I47) isolated the tumour-necrotising lignans podophyllotoxin (22) and deoxypodo- References, phyllotoxin (23) as well as the inactive savinin (24). The tumour-necrotising activity seems to be characteristic of phenyltetraline lactones possessing the arrangement of the lactone ring and the configuration of deoxypodophyllotoxin.…”

Antimalarial activity of abietane ferruginol analogues possessing a phthalimide group

“…1) was first isolated in 1939 from New Zealand's Miro tree (Podocarpus ferruginea), and has been extensively studied because of intriguing chemical framework and promising biological properties. 6 Ferruginol (1) occurs in plants belonging to the Podocarpaceae, Cupressaceae, Lamiaceae and Verbenaceae families among others. This diterpene exhibited important bioactivities, such as antimicrobial, 7 cardioactive, 8 antioxidative, 9 antileishmanial and nematicidal, 10 and antiulcer properties.…”