221-P Flow crossmatch bimodal distribution for T cell treated with pronase

López, Ricardo; AlZahrani, Saber; Awaji, Mohammed I.; Housawi, Abdulrahman; Saghier, Mohammed I. Al; Khan, Faisal; Berka, Noureddine

doi:10.1016/j.humimm.2011.07.246

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Luminex Sa Sp Assay: Technical Challenges Correlation Of Dsa1

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2014

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“…FC CM is the most sensitive immunological method and it allows for the detection of DSA in TC serum. Positive FC CM is associated with an elevated risk of AMR [12,16,17,21,32,[104][105][106][107] . The accurate detection of the spectrum of anti-HLA antibodies is critical for organ allocation and the prediction of FC CM results.…”

Section: Luminex Sa Sp Assay: Technical Challenges Correlation Of Dsamentioning

confidence: 99%

Methodological aspects of anti-human leukocyte antigen antibody analysis in solid organ transplantation

Lobashevsky¹

2014

WJT

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Donor human leukocyte antigen (HLA)-specific antibodies (DSA) play an important role in solid organ transplantation. Preexisting IgG isotype DSA are considered a risk factor for antibody mediated rejection, graft failure or graft loss. The post-transplant development of DSA depends on multiple factors including immunogenicity of mismatched antigens, HLA class Ⅱ typing of the recipient, cytokine gene polymorphisms, and cellular immunoregulatory mechanisms. De novo developed antibodies require special attention because not all DSA have equal clinical significance. Therefore, it is important for transplant clinicians and transplant immunologists to accurately characterize DSA. In this review, the contemporary immunological techniques for detection and characterization of anti-HLA antibodies and their pitfalls are described.

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Section: Luminex Sa Sp Assay: Technical Challenges Correlation Of Dsamentioning

confidence: 99%

Methodological aspects of anti-human leukocyte antigen antibody analysis in solid organ transplantation

Lobashevsky¹

2014

WJT

View full text Add to dashboard Cite

show abstract

221-P Flow crossmatch bimodal distribution for T cell treated with pronase

Cited by 1 publication

References 0 publications

Methodological aspects of anti-human leukocyte antigen antibody analysis in solid organ transplantation

Methodological aspects of anti-human leukocyte antigen antibody analysis in solid organ transplantation

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