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Rinker, R.; Friday, Karen E.; Aydın, Faruk; Jaffe, Bernard M.; Lambiase, Louis

doi:10.1023/a:1018844022084

Cited by 18 publications

(3 citation statements)

References 57 publications

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“…We are aware of 1 trial with octreotide in 3 patients, but each of these patients eventually underwent operative treatment (10). Diazoxide has also been used but without notable success (6). The combination of verapamil and acarbose has been reported to be effective, but documentation of PHH and durability of the therapy are incompletely documented in this case (19).…”

Section: Discussionmentioning

confidence: 99%

Successful Treatment of Persistent Hyperinsulinemic Hypoglycemia with Nifedipine in an Adult Patient

Guseva¹,

Phillips

Mordes³

2010

Endocrine Practice

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Objective To describe the successful treatment of severe noninsulinoma hyperinsulinemic hypoglycemia with use of a calcium channel blocking agent in an adult patient who had previously undergone a gastric bypass surgical procedure. Methods A 65-year-old woman who had undergone a gastric bypass surgical procedure 26 years earlier was hospitalized because of severe postprandial hypoglycemia. During and after hospitalization, the patient underwent assessment with conventional measurements of glucose, insulin, proinsulin, and C-peptide; toxicologic studies; magnetic resonance imaging studies of the pancreas; and determination of hepatic vein insulin concentrations after selective splanchnic artery calcium infusion. Results Metabolic variables were consistent with the diagnosis of hyperinsulinemic hypoglycemia. Magnetic resonance imaging revealed the presence of a side branch intraductal papillary mucinous tumor that had been stable for more than 1 year. The results of the calcium-stimulated insulin release study were consistent with nonlocalized hypersecretion of insulin. A trial of frequent small feedings failed to prevent hypoglycemia. On the basis of reports of successful treatment of childhood nesidioblastosis, the patient was then prescribed nifedipine, 30 mg daily. She has subsequently remained free of symptomatic hypoglycemia for 20 months. Conclusion A calcium channel blocking agent may be efficacious and a potential alternative to partial pancreatectomy in cases of noninsulinoma hyperinsulinemic hypoglycemia in adults.

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Section: Discussionmentioning

confidence: 99%

Successful Treatment of Persistent Hyperinsulinemic Hypoglycemia with Nifedipine in an Adult Patient

Guseva¹,

Phillips

Mordes³

2010

Endocrine Practice

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“…When the literature was found only as a reference in another original paper, we describe this in the “literature” section of Supplementary Table S1 . The references for Supplementary Table S1 can be found in the reference section [ 3 , 5 , 7 , 11 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , …”

Section: Methodology Of the Literature Research And Limitationsmentioning

confidence: 99%

“…However, according to the available literature, the disease is rare. When excluding post-bariatric surgery patients and patients with diagnosed syndromes (such as MEN1), we could identify approximately 535 cases (approximately 560 when counting the “adolescent” cases reported by Castillo-López et al [ 247 ]), although some of these cases, especially early ones and where the full text is not available/is written in another language than English/German, or demographic data are missing, are equivocal [ 3 , 5 , 7 , 11 , 14 , 15 , 16 , 17 , 18 , 19 , 22 , 23 , 25 , 26 , 27 , 29 , 30 , 31 , 33 , 34 , 35 , 39 , 40 , 41 , 43 , 45 , 46 , 47 , 48 , 49 , 50 , 52 , 54 , 55 , 56 , 57 , 58 , 59 , 61 , 62 , 63 , 66 , 67 , 68 , 69 , 70 , 71 ...…”

Section: Epidemiologymentioning

confidence: 99%

Diffuse, Adult-Onset Nesidioblastosis/Non-Insulinoma Pancreatogenous Hypoglycemia Syndrome (NIPHS): Review of the Literature of a Rare Cause of Hyperinsulinemic Hypoglycemia

Dieterle,

Husari,

Prozmann

et al. 2023

Biomedicines

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Differential diagnosis of hypoglycemia in the non-diabetic adult patient is complex and comprises various diseases, including endogenous hyperinsulinism caused by functional β-cell disorders. The latter is also designated as nesidioblastosis or non-insulinoma pancreatogenous hypoglycemia syndrome (NIPHS). Clinically, this rare disease presents with unspecific adrenergic and neuroglycopenic symptoms and is, therefore, often overlooked. A combination of careful clinical assessment, oral glucose tolerance testing, 72 h fasting, sectional and functional imaging, and invasive insulin measurements can lead to the correct diagnosis. Due to a lack of a pathophysiological understanding of the condition, conservative treatment options are limited and mostly ineffective. Therefore, nearly all patients currently undergo surgical resection of parts or the entire pancreas. Consequently, apart from faster diagnosis, more elaborate and less invasive treatment options are needed to relieve the patients from the dangerous and devastating symptoms. Based on a case of a 23-year-old man presenting with this disease in our department, we performed an extensive review of the medical literature dealing with this condition and herein presented a comprehensive discussion of this interesting disease, including all aspects from epidemiology to therapy.

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Adult-Onset Nesidioblastosis Causing Hypoglycemia

Witteles

Straus²,

Sugg³

et al. 2001

Arch Surg

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Hypothesis: Nesidioblastosis is an important cause of adult hyperinsulinemic hypoglycemia, and control of this disorder can often be obtained with a 70% distal pancreatectomy. Design: The records of all adult patients operated on for hypoglycemia between 1974 and 1999 were reviewed retrospectively. Patients with the pathologic diagnosis of nesidioblastosis were contacted for follow-up (1.5-21 years) and are presented. Patients' results were compared with those of 36 other individuals with this disorder who were previously reported in the literature.

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Untitled

Cited by 18 publications

References 57 publications

Successful Treatment of Persistent Hyperinsulinemic Hypoglycemia with Nifedipine in an Adult Patient

Successful Treatment of Persistent Hyperinsulinemic Hypoglycemia with Nifedipine in an Adult Patient

Diffuse, Adult-Onset Nesidioblastosis/Non-Insulinoma Pancreatogenous Hypoglycemia Syndrome (NIPHS): Review of the Literature of a Rare Cause of Hyperinsulinemic Hypoglycemia

Adult-Onset Nesidioblastosis Causing Hypoglycemia

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