23 Effect of chlorpheniramine (C) vs placebo (P) on nose and ear function of atopic subjects before and after histamine nasal challenge

Drug treatment for nasal allergy

“…In controlled clinical trials of patients with perennial rhinitis due to the house dust mite, terfenadine has been shown to be as elTective as chlorpheniramine in relieving symptoms of sneezing, rhinorrhoea and itching of the nose, throat and palate. Neither drug relieves nasal congestion [36,37] but terfenadine has less effect on alertness and cognitive abilities [38]. Like the majority of nasal decongestants, many antihistamines.…”