231. Zum Infektionsrisiko der Bauchdrainage

Abstract

In a prospective study on 212 patients who had aseptic and conditioned aseptic operations, smears from the region of drainage and from the drainage material itself were taken per-and postoperatively. Whereas bacterial contamination was found in 13% and 54% of the aseptic and conditioned aseptic operations respectively during surgery, 18 % and 32 % revealed positive proof of bacterial infection postoperatively. From the analysis of the type of bacteria it can be assumed that migration of bacteria from the skin through the drainage tube can occur. Zusammenfassung. In einer prospektiven Studie bei 212 Patienten mit aseptischen und bedingt aseptischenOperationen wurden intra-und postoperativ Abstriche vom Drainzielgebiet und Wunddrain zur bakteriologischen Untersuchung entnommen. W~ihrend bei aseptischen Eingriffen in 13 %, bzw. bei bedingt aseptischen Eingriffen in 54 % ein positiver bakterieller Befund am Operationssitus festgestellt wurde, fand sich postoperativ am Wunddrain in 18% bzw. 32% ein positiver Keimnachweis. Die Analyse der Keimarten erlaubt die Vermutung, dab eine Migration von Hautkeimen durch das Wunddrain m6glich ist. Schliisselw~Jrter: Bauchh6hlendrainage -Kontamination -Infektion.Summary. Diagnosis of peritonitis by clinical signs is difficult in critically ill patients. Instead we found renal and pulmonary insufficiency to be of diagnostic value in 56 cases. The discriminating laboratory parameters were: creatinine clearance < 70ml/min and/or arterial pO 2 < 70ram Hg or FiO2 > 0.5, revealing peritonitis in

Effect of pH on the micellar properties of amphiphilic drugs in aqueous solution

“…The data were fitted to a stepwise association as described previously (Attwood & Agarwal 1980). The monomer concentration [b,] was determined as a function of the total solution concentration c (g dm-8) by integration of the light scattering data according to Steiner (1952): theoretical scattering calculated using stepwise association Model 2 (eqn 10) with K = 31.3 dma mol-I.…”

Light-Scattering Studies on Bile Acid Salts I: Pattern of Self-Association of Sodium Cholate, Sodium Glycocholate, and Sodium Taurocholate in Aqueous Electrolyte Solutions

“…The various association constants Kz, K3, etc., can be obtained by the method developed by Steiner (20). According to this method of analysis, the weight-average molecular weight of the aggregates is related to weight concentration, c (grams per milliliter), by:…”

“…Stepwise Association Models-Attwood and Udeala (21,22) showed that the method of Steiner (20) can be utilized to differentiate between various association models for the self-association of various antihistamines by light-scattering techniques. In the present study, the method of Steiner was applied to gain insight into the self-association of the bile salts.…”

Light-Scattering Studies on Bile Acid Salts II: Pattern of Self- Association of Sodium Deoxycholate, Sodium Taurodeoxycholate, and Sodium Glycodeoxycholate in Aqueous Electrolyte Solutions

“…To obtain an accurate representation of the self-association pattern of any compound, it is necessary to obtain information about the variation of the monomer concentration, b, as a function of the total concentration of the associating species (8,16). For light scattering, Steiner (16) developed a method for obtaining this information.…”

“…Moreover, some higher aggregates must form to account for the slowly increasing trend of N , with b. To determine the nature and size of the higher aggregates formed, the method of Steiner (16) was applied. In this method, it is assumed that aggregate growth occurs in a stepwise fashion such as is given by Eq.…”