237 Transfer of 3h-1–25 Dihydroxyvitamin D3 (3H-1.25 D3) From the Fetus to the Mother in Ovine Model

Abstract

The r o l e of PGs i n t h e maintenance and t h e control of f e t a l and p l a c e n t a l hemodynamics was suggested. Umbilical vessels having smooth muscle t h a t i s not innervated may be p a r t i c u l a r l y responsive t o vasoactive agents such a s PGs. S i x UA were f r e s h l y obtained from normal term pregnancies. Biosynthesis of PGE2, PGF2c(, thromboxane A2 (analyzed a s TxB2) and prostacyclin (PG12) (Measured a s 6-keto PGFla) was studied by incubating UA microsomes with (14c) arachidonic acid (M) and with (14c) c y c l i c P G endoperoxide (PGH2), separation by t h i n l a y e r chromatograph and