238 Impact of super-dosing phytase in diets fed to 40 kg, 60 kg and 80 kg pigs on phytate catabolism

Holloway, Cassie; Boyd, R. D.; Walk, C. L.; Patience, John F.

doi:10.2527/msasas2016-238

Cited by 7 publications

(6 citation statements)

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“…In the current experiment, the 500 FTU/kg phytase dose numerically increased ileal InsP4 and InsP3 concentrations, whereas the higher dose reduced them to levels below that of non-supplemented diets. Similar findings were reported by Holloway et al (2016). Despite the more extensive phytate hydrolysis, the high phytase dose had little impact on the recorded measures of Fe status, and therefore these results do not support the original hypothesis.…”

Section: Ileal Phytate Hydrolysis and Myo Generationsupporting

confidence: 61%

Super-dosing phytase improves the growth performance of weaner pigs fed a low iron diet

Laird

Kühn

Miller

2018

Animal Feed Science and Technology

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Section: Ileal Phytate Hydrolysis and Myo Generationsupporting

confidence: 61%

Super-dosing phytase improves the growth performance of weaner pigs fed a low iron diet

Laird

Kühn

Miller

2018

Animal Feed Science and Technology

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“…These results are in agreement with Laird et al (2016), who demonstrated that super-dosing phytase (2,000 to 8,000 FTU/kg) improved portal and peripheral serum myo-inositol concentrations in weaner, grower, and finisher pigs. Holloway et al (2016) reported that increasing levels of phytase reduced the concentration of phytate (IP 6 ) and IP 5 and increased the concentration of IP 4 , IP 3 , and inositol in ileal digesta when up to 2,500 FTU/kg of phytase was fed, suggesting intestinal degradation of phytate. In 2 experiments with broilers conducted by Cowieson et al (2015), plasma myo-inositol increased from 47, 56, 62, and 65 mg/L when feeding 0, 1,000, 2,000, and 3,000 phytase units in Exp.…”

Section: Discussionmentioning

confidence: 99%

Effects of super-dosing phytase and inositol on growth performance and blood metabolites of weaned pigs housed under commercial conditions1

Moran

Wilcock

Elsbernd³

et al. 2019

Journal of Animal Science

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A total of 2,156 weaned pigs (6.75 ± 0.11 kg BW) were used in a 42-d study to evaluate whether improvements in growth performance associated with super-dosing phytase can be explained by the complete dephosphorylation of phytate and liberation of inositol. Two phytase doses (0 and 2,500 FTU/kg) and 3 inositol concentrations (0%, 0.15%, and 0.30%) were combined to create 6 dietary treatments in a 2 × 3 factorial arrangement. Pigs were fed a 3-phase feeding program, with periods being 10, 10, and 22 d, respectively. Blood samples were collected on days 0, 21, and 42 from a subset of 48 pigs to analyze mineral and myo-inositol concentrations. During Phase 1, super-dosing phytase tended to improve ADG compared with pigs fed diets without phytase (P = 0.09). Increasing concentrations of inositol improved the efficiency of gain in pigs fed diets without phytase (1,022.1, 1,040.9, and 1,089.2 g/kg), but not diets with phytase (1,102.2, 1,087.2, and 1,076.2 g/kg), and this improvement was equivalent to that observed with super-dosing phytase in the absence of inositol (interaction, P = 0.015). During Phase 2, super-dosing phytase improved ADG (P = 0.001), resulting in heavier BW (P = 0.007). During Phase 3 and overall, inositol supplementation increased ADG and ADFI in a quadratic manner (P < 0.10), with the highest ADG and ADFI observed for pigs fed 0.15% of inositol. Super-dosing phytase increased serum Zn on day 21, but not on day 42 (interaction, P = 0.008), increased serum Cu (P = 0.01), but decreased serum Fe (P = 0.02). Plasma myo-inositol increased linearly from 66.9 to 97.1 and 113.2 nmol/mL with increasing inositol (P < 0.001). When plasma myo-inositol was analyzed within the subgroup of pigs fed diets without added inositol, super-dosing phytase increased plasma myo-inositol from 57.81 to 76.05 nmol/mL (0 and 2,500 FTU/kg, respectively; P = 0.05). Results demonstrate that exogenous inositol improved efficiency of gain in weaned pigs to the same level as that observed with super-dosing phytase, but this occurred only during the first 10 d of the nursery period. This suggests that the improvement in efficiency of growth when applying super-dosing phytase could be linked, in part, to complete dephosphorylation of phytate and liberation of myo-inositol, and that myo-inositol had a greater metabolic impact in piglets immediately after weaning. Consequently, myo-inositol may be a conditionally essential nutrient for young pigs during weaning stress, but further research is needed to prove this hypothesis.

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“…Dietary supplementation of phytase to improve the availability of phytate-bound P and superdosing with phytase to mitigate antinutritional effects of phytate and to lower phytate esters by almost complete destruction of the phytate molecule are common practices in the animal feed industry (Walk et al, 2014;Holloway et al, 2016a). Although phytase is not often used in nursery diets for young pigs immediately after weaning, it may be a means to mitigate the impact of high phytate levels associated with SBM addition.…”

Section: Introductionmentioning

confidence: 99%

Effects of high inclusion of soybean meal and a phytase superdose on growth performance of weaned pigs housed under the rigors of commercial conditions1

Moran

Boyd

Zier-Rush³

et al. 2017

Journal of Animal Science

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Two studies were conducted to determine whether soybean meal (SBM) use in nursery pig diets can be increased by superdosing with phytase. In Exp. 1, 2,550 pigs (BW of 5.54 ± 0.09 kg) were used to evaluate the optimal level of phytase in low- or high-SBM diets. Two SBM levels (low and high) and 4 phytase doses (0, 1,250, 2,500, and 3,750 phytase units [FTU]/kg) were combined to create 8 dietary treatments in a 2 × 4 factorial arrangement. Pigs were fed a 3-phase feeding program, with each period being 10, 10, and 22 d, respectively. Inclusion of low and high SBM was 15.0 and 25.0%, respectively, for Phase 1; 19.0 and 29.0%, respectively, for Phase 2; and 32.5% for the common Phase 3 diet. Pigs fed diets with high SBM had improved G:F for Phase 1 and 2 and overall ( < 0.01) compared with low-SBM diets. Phytase quadratically improved G:F during Phase 3 and overall ( < 0.05), with the optimum phytase dose being 2,500 FTU/kg. High-SBM diets tended ( = 0.09) to decrease stool firmness (determined daily from d 1 to 10) only on d 2. In Exp. 2, 2,112 pigs (BW of 5.99 ± 0.10 kg) were used to evaluate the impact of high levels of SBM and phytase on performance, stool firmness, mortality, and morbidity in weaned pigs originating from a porcine reproductive and respiratory syndrome (PRRS) virus-positive sow farm. Pigs were fed a 3-phase feeding program as in Exp. 1. Three levels of SBM (low, medium, or high) and 2 phytase levels (600 or 2,600 FTU) were combined to create 6 dietary treatments in a 3 × 2 factorial arrangement. Inclusion of SBM was 15.0, 22.5, and 30.0% for Phase 1 and 20.0, 27.5, and 35.0% for Phase 2 for low, medium, and high SBM, respectively, and 29.0% for the common Phase 3 diet. Inclusion of SBM did not affect growth performance. The percentage of pigs removed for medical treatment linearly declined with increasing SBM levels ( = 0.04). High-SBM diets tended ( < 0.10) to decrease stool firmness during d 4 and 5 and high phytase tended ( < 0.10) to improve stool firmness on d 2 and 4. Analyzed PRRS titers in saliva samples collected on d 20 and 42 confirmed the PRRS status of the pigs; however, viral load was not impacted by dietary treatments ( ≥ 0.11). Results indicate that SBM levels in early nursery diets can be increased without decreasing growth performance and may be favorable in pigs originating from PRRS-positive sow farms by reducing costs of medical treatments. Supplementation of phytase at superdose levels can improve growth performance independently from the level of SBM in the diet.

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238 Impact of super-dosing phytase in diets fed to 40 kg, 60 kg and 80 kg pigs on phytate catabolism

Cited by 7 publications

References 0 publications

Super-dosing phytase improves the growth performance of weaner pigs fed a low iron diet

Super-dosing phytase improves the growth performance of weaner pigs fed a low iron diet

Effects of super-dosing phytase and inositol on growth performance and blood metabolites of weaned pigs housed under commercial conditions1

Effects of high inclusion of soybean meal and a phytase superdose on growth performance of weaned pigs housed under the rigors of commercial conditions1

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