24-hour ambulatory blood pressure monitoring and hypertension related risk among HIV-positive and HIV-negative individuals: cross sectional study findings from rural Uganda

Niwaha, Anxious J.; Wosu, Adaeze C.; Namugenyi, Christabellah; Kayongo, Alex; Nyirenda, Moffat; Siddharthan, Trishul; Checkley, William; Semitala, Fred C.; Kalyesubula, Robert

doi:10.1038/s41371-020-00464-6

Cited by 2 publications

(2 citation statements)

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“…The details of recruitment have been published elsewhere. 24 Briefly, we recruited PLHIV and PwoHIV living in Nakaseke District. PLHIV were recruited from the ART clinics of Nakaseke general hospital and Bidabujja Health Centre.…”

Section: People Living With Hivmentioning

confidence: 99%

“…24-hour ABPM was done using a 24-hour ABPM monitor (Contec Medical Systems Co., Ltd, Qinhuangdao, China) oscillometric device with an appropriate cuff for midupper arm circumference (small, 20-24 cm; medium, 24-32 cm; large, 32-38 cm) as previously described. 25 But briefly, BP monitors were fitted on a regular working day (i.e. a day during which participants would be undertaking their regular daily activities).…”

Section: -Hour Abpmmentioning

confidence: 99%

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Nocturnal systolic blood pressure dipping among people living with HIV and people without HIV: a cross-sectional study in Rural Uganda

Sekitoleko,

Kansiime,

Mugamba

et al. 2024

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BackgroundIn this study, we investigated sleep quality, depression and stress symptoms as hypothesized factors affecting the association between HIV status and nocturnal blood pressure dipping status in rural Uganda.MethodsIndividuals living with HIV (PLHIV) and people without HIV (PwoHIV) underwent 24-hour ambulatory blood pressure monitoring (ABPM) and classified as extreme dippers, dippers and non-dippers based on a percentage nocturnal drop in mean systolic and diastolic blood pressure. Ordinal logistic regression models were used to assess the effect of different exposure variables (HIV status, sleep quality and other covariates) on the outcome (dipping status).ResultsThe median age was 45 years (IQR: 35-54) and 80% of the participants were female. 24% of PwoHIV and 16% of PLHIV were overweight, 10% of HIV negative and 3% of the HIV positive individuals were obese. Depression was prevalent in both PLHIV and PwoHIV. Additionally, poor sleep quality was more prevalent in PLHIV compared to PwoHIV (70% versus 58%, P= 0.046). The study found that 53% of participants had normal dipping, while 35.1% were non-dippers, with non-dipping being more prevalent in PwoHIV individuals (34.9% vs 29.7%, P<0.001). PLHIV had 3.6 times the odds of being extreme dippers compared to PwoHIV (OR 3.64, 95% CI: 1.40 – 9.44).ConclusionThis study identified high proportions of non-dipping BP profiles among both PLHIV and PwoHIV. However, the odds of being extreme dippers were higher among PLHIV compared to PwoHIV. Further research is needed to understand the underlying mechanisms contributing to extreme dipping patterns in PLHIV.

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Section: People Living With Hivmentioning

confidence: 99%

Section: -Hour Abpmmentioning

confidence: 99%