24‐hour blood pressure profiles in hypertensive patients administered ramipril or placebo once daily: Magnitude and duration of antihypertensive effects

Abstract

Summary:Ramipril is a new, potent nonsulfhydryl inhibitor of angiotensin converting enzyme. The magnitude and duration of its antihypertensive effect were evaluated in a multicenter, placebo-controlled, randomized clinical trial conducted in 100 patients with mild to moderate essential hypertension. Ramipril significantly reduced both supine and standing blood pressures measured 24 h after dosing. Automated blood pressure monitoring showed that ramipril significantly reduced systolic and diastolic pressures for 24 h after dosing. The peak effect occurred between 3 and 6 h after dosing, with approximately 50% of this efiect retained after 24 h. Ramipril was well tolerated; there was no significant difference between active drug and placebo in the overall incidence of side effects. Ramipril is an effective and well-tolerated antihypertensive agent, which reduces both supine and standing blood pressure over the entire 24-h period after dosing.

Comparative Effects of Ramipril on Ambulatory and Office Blood Pressures

“…8,9 The peak/trough ratio of ramipril administered once daily is about 0.5, ie, Ϸ50% of the maximum effect is still present after 24 hour. [7][8][9] OBP in this substudy (and, most likely, in the HOPE patients overall) was measured Ϸ12 hours after administration of ramipril. The usual finding in antihypertensive studies is a more pronounced effect of treatment on OBP than on ABP.…”

The effect of telmisartan and ramipril on early morning blood pressure surge: a pooled analysis of two randomized clinical trials

“…We used pooled data from two identical randomized trials to compare the efficacy of ramipril, an angiotensinconverting enzyme inhibitor with a trough-to-peak ratio with once-daily dosing of approximately 50% [14], and telmisartan, an angiotensin II receptor blocker with a trough-to-peak ratio of > 90% [15], on the magnitude of the EMBPS.…”

The impact of one or two missed doses on the duration of action of combined perindopril and indapamide

“…Graphic display of the changes in blood pressure over 24 h will usually demonstrate the effects of the antihypertensive drug including any loss in BP control toward the end of the dosing interval. 17 Although ambulatory BP recordings are not always reproducible in the individual patient, group mean data are highly reproducible and consistent over time. 18 Even among individuals, the 24-h ambulatory BP shows greater reproducibility than does the office BP, which tends to exhibit a regression to the mean phenomenon.…”