24-hour pH Monitoring and Pathological Findings of Patients with Laryngo Pharyngeal Reflux Disease (LPRD).

Successful treatment of radiation-induced mucositis with proton pump inhibitor administration: A report of two laryngeal cancer cases

“…The putative contribution of LPR was deduced from the fact that radiation-induced mucositis ameliorated after PPI administration. Nakamura showed that, on pathological examination, LPR caused mucosal damage in the postcricoid area [4]; however, in patient 2, PPI-responsive mucositis was apparent in the epiglottic vallecula. Therefore, it could be speculated that, in some cases, LPR may damage a wide area of the pharyngeal mucosa, reaching as far as the epiglottic vallecula, which may be one of the causes of severe radiation-induced mucositis.…”

“…Chronic stress caused by LPR [4] could make the laryngeal/pharyngeal membrane more susceptible to irradiation damage. However, to our knowledge, there have been no investigations of the relationship between LPR and radiation-inducedmucositis.…”