24-Hour Profile of Blood Pressure, Heart Rate, Excretion of Electrolytes, and Locomotor Activity in Wistar-Kyoto and SHR Rats Under Conditions of Free-Run Rhythm

Благонравов, М. Л.; Medvedeva, Ekaterina V.; Bryk, A. A.; Goryachev, V. A.; Rabinovich, A E; Letoshneva, A S; Demurov, E. A.

doi:10.1007/s10517-018-4312-6

Cited by 4 publications

(3 citation statements)

References 5 publications

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“…At the same time, the absence of rhythmological changes in BP and HR in SHR rats indicated a more stable and rigid character of these functions. The obtained data are consistent with our previous studies, showing similar patterns of the responses under free-run rhythm and the conditions of prolonged daylight duration [29,30].…”

Section: Discussionsupporting

confidence: 92%

“…We have to mention that an increase in the concentration of aMT6s over the day has already been noted in some of our previous work. In SHR rats, the prolongation of the light phase of the day to 20 h (the ratio of light/dark phases was 20 h:4 h) was accompanied by a significant increase in the aMT6s content in urine in the daytime period; under the standard light pattern (12 h:12 h), it was 16.27 ± 1.23 ng/mL, and under the light/dark pattern (20 h:4 h), it was elevated to 27.39 ± 1.13 ng/mL [ 30 ]. It can be assumed that an increase in the daytime blood level of melatonin both under the extended light phase of the day and in the case of monochromatic blue light action is associated with an enhancement of serotonin (5-hydroxytryptamine) formation.…”

Section: Discussionmentioning

confidence: 99%

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Daytime Exposure to Blue Light Alters Cardiovascular Circadian Rhythms, Electrolyte Excretion and Melatonin Production

et al. 2022

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Artificial light is characterized by certain features of its impact on the body in terms of its spectral distribution of power, duration of exposure and intensity. Short waves, perceived as blue light, are the strongest synchronizing agent for the circadian system. In the present work, we investigated the features of the circadian rhythms of blood pressure (BP), heart rate (HR), the excretion of electrolytes and the secretion of melatonin in normotensive (Wistar–Kyoto) and hypertensive (SHR) rats under the action of monochromatic blue light in the daytime period. It was found that the exposure of Wistar–Kyoto rats to monochromatic blue light was accompanied by a significant decrease in nighttime and 24h systolic BP. The most remarkable changes are characteristic of the HR in SHR rats under monochromatic light. A significant decrease in HR in each time period was found, but the predominance of nighttime over daytime values remained in SHR animals. There was also a significant increase in the mesor of the HR in SHR rats. Additionally, the amplitude of diastolic BP and HR, as well as the range of oscillations in HR, were significantly increased compared with the standard light pattern. In contrast to SHR rats, the regulation of the circadian rhythms in Wistar–Kyoto rats was more flexible and presented more changes, which may be aimed at the adaptation of the body to environmental conditions. For Wistar–Kyoto rats, an increase in the level of excreted electrolytes was observed under the action of monochromatic light, but no similar changes were found in SHR rats. For Wistar–Kyoto rats, a significant decrease in the urine concentration of aMT6s in the daytime and nighttime periods is characteristic, which results in the loss of the circadian rhythm. In SHR rats, there was a significant decrease in the nighttime content of aMT6s in the urine, while the daytime concentration, on the contrary, increased. The obtained data demonstrate that prolonged exposure to monochromatic blue light in the daytime period affects the circadian structure of the rhythms of the cardiovascular system, the rhythm of electrolyte excretion and the production of epiphyseal melatonin in wild-type and hypertensive animals. In SHR rats, the rhythms of BP and HR exhibit a more rigid pattern.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Daytime Exposure to Blue Light Alters Cardiovascular Circadian Rhythms, Electrolyte Excretion and Melatonin Production

et al. 2022

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“…These changes in the circadian profile of BP are also confirmed by a reduced percentage of the 24 h rhythm with the predominance of ultradian rhythms [4]. This profile of the circadian rhythm is characteristic of disorders of water-salt metabolism [48][49][50][51]. Analysis of ALI in this group revealed an increase in the number of patients with increased HR (over 80 bpm) in addition to the changes in CI.…”

Section: Discussionmentioning

confidence: 52%

Features of Allostatic Load in Patients with Essential Hypertension without Metabolic Syndrome Depending on the Nature of Nighttime Decreases in Blood Pressure

Zotova,

Lukanina,

Blagonravov

et al. 2023

Diagnostics

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Changes in the activity of the renin–angiotensin–aldosterone system are responsible for a stable shift in the regulation of the cardiovascular system in essential hypertension (EH). They can be characterized as hemodynamic allostasis. The purpose of our study was to determine the role of hemodynamic parameters in allostatic load in patients with EH without metabolic syndrome. Twenty-four hours of ambulatory blood pressure monitoring was performed, followed by linear and non-linear rhythm analysis. Based on the daily index, patients with EH were divided into two groups: group 1—patients with no significant nighttime decrease in blood pressure (BP); group 2—patients who had a nocturnal decrease in BP. The control group included healthy persons aged 25 to 69 years. A linear analysis was used to determine the mean values of systolic and diastolic BP, heart rate (HR), time load of BP, circadian index, and structural point of BP. Non-linear analysis was applied to determine the mesor, amplitude, range of oscillations and % rhythm of BP and HR. The allostatic load index (ALI) was also calculated on the basis of the corresponding biomarkers. It was found that ALI was significantly higher in groups 1 and 2 in comparison with the control group. The hemodynamic mechanisms of this increase were different.

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Ion dynamics and the regulation of circadian cellular physiology

Stangherlin

2023

American Journal of Physiology-Cell Physiology

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Circadian rhythms in physiology and behaviour allow organisms to anticipate the daily environmental changes imposed by the rotation of our planet around its axis. Although these rhythms eventually manifest at the organismal level, a cellular basis for circadian rhythms has been demonstrated. Significant contributors to these cell-autonomous rhythms are daily cycles in gene expression and protein translation. However, recent data revealed cellular rhythms in other biological processes, including ionic currents, ion transport, and cytosolic ion abundance. Circadian rhythms in ion currents sustain circadian variation in action potential firing rate, which coordinates neuronal behaviour and activity. Circadian regulation of metal ions abundance and dynamics is implicated in distinct cellular processes, from protein translation to membrane activity and osmotic homeostasis. In turn, studies showed that manipulating ion abundance affects the expression of core clock genes and proteins, suggestive of a close interplay. However, the relationship between gene expression cycles, ion dynamics and cellular function is still poorly characterised. In this review, I will discuss the mechanisms that generate ion rhythms, the cellular functions they govern and how they feed back to regulate the core clock machinery.

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24-Hour Profile of Blood Pressure, Heart Rate, Excretion of Electrolytes, and Locomotor Activity in Wistar-Kyoto and SHR Rats Under Conditions of Free-Run Rhythm

Cited by 4 publications

References 5 publications

Daytime Exposure to Blue Light Alters Cardiovascular Circadian Rhythms, Electrolyte Excretion and Melatonin Production

Daytime Exposure to Blue Light Alters Cardiovascular Circadian Rhythms, Electrolyte Excretion and Melatonin Production

Features of Allostatic Load in Patients with Essential Hypertension without Metabolic Syndrome Depending on the Nature of Nighttime Decreases in Blood Pressure

Ion dynamics and the regulation of circadian cellular physiology

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